Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (
Reproductive Biology and Endocrinology, 2011 Fertilin alpha (ADAM-1) and beta (ADAM-2) are integral membrane proteins of the ADAM family that form a fertilin complex involved in key steps of the sperm-oocyte membrane interaction.
Bonet Sergi +6 more
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ADAM and ADAMTS Proteins, New Players in the Regulation of Hepatocellular Carcinoma Microenvironment [PDF]
Cancers, 2021 The tumor microenvironment plays a major role in tumor growth, invasion and resistance to chemotherapy, however understanding how all actors from microenvironment interact together remains a complex issue. The tumor microenvironment is classically represented as three closely connected components including the stromal cells such as immune cells ...
Nathalie Théret +4 more
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ADAM-17 Is Activated by the Mitogenic Protein Kinase ERK in a Model of Kidney Fibrosis [PDF]
The American Journal of the Medical Sciences, 2010 Chronic kidney disease affects 1 of 9 Americans. Recent studies showed increased activation of the metalloenzyme disintegrin ADAM-17 during the development of the disease and that threonine phosphorylation of ADAM-17 may be an important regulator of the enzyme activity.
L. Gabriel Navar +3 more
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Polymeric ADAM Protein Mimics Interrogate Mammalian Sperm–Egg Binding [PDF]
ChemBioChem, 2009 AbstractROMPing with the ADAMs family: The sperm‐surface display of egg adhesion proteins was investigated using multivalent polymer sperm mimics. Ruthenium‐catalyzed ring opening metathesis polymerization (ROMP) was used to synthesize heterovalent polymers.magnified imageThe sperm proteins ADAM2 and ADAM3, members of the ADAM family of proteins, have ...
Younjoo Lee, Nicole S. Sampson
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ADAM 12 Cleaves Extracellular Matrix Proteins and Correlates with Cancer Status and Stage [PDF]
Journal of Biological Chemistry, 2004 ADAM 12 is a member of a family of disintegrin-containing metalloproteases that have been implicated in a variety of diseases including Alzheimer's disease, arthritis, and cancer. We purified ADAM 12 from the urine of breast cancer patients via Q-Sepharose anion exchange and gelatin-Sepharose affinity chromatography followed by protein identification ...
Roopali Roy +4 more
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S141 A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis [PDF]
Thorax, 2010 Background The asthma and chronic obstructive pulmonary disease (COPD) gene, A Disintegrin And Metalloproteinase (ADAM)33 , is selectively expressed in mesenchymal cells and its metalloprotease activity has been linked to angiogenesis and airway remodelling.
A. S. Shaffiq +7 more
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Domain integration of ADAM family proteins: Emerging themes from structural studies
Experimental Biology and Medicine, 2019 ADAM (a disintegrin and metalloproteinase) proteins are type-1 transmembrane and secreted proteins that function in cell adhesion and signal transduction. Here we review the structural features of ADAM proteins that direct their biological functions in ectodomain shedding and cell adhesion.
T.C.M. Seegar, Stephen C. Blacklow
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The role of some ADAM-proteins and activation of the insulin growth factor-related pathway in colorectal cancer. [PDF]
Cent Eur J Immunol, 2018 Walkiewicz K +3 more
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Revista de la Facultad de Medicina Humana, 2021 Objective: To determine the association between the presence of V4 polymorphisms of the ADAM33 gene and asthma disease and to describe the frequency of T1 polymorphism in patients from a hospital in the Lambayeque region. Materials and methods: Design of
Clarisa Carolina Arrascue Vega +4 more
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Role of ADAM and ADAMTS proteases in pathological tissue remodeling
Cell Death Discovery, 2023 Pathological tissue remodeling is closely associated with the occurrence and aggravation of various diseases. A Disintegrin And Metalloproteinases (ADAM), as well as A Disintegrin And Metalloproteinase with ThromboSpondin motifs (ADAMTS), belong to zinc ...
Zhaoni Wang +3 more
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