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Structure-Activity Relationship Studies on ADAM Protein-Integrin Interactions
Cardiovascular & Hematological Agents in Medicinal Chemistry, 2007The ADAM (a disintegrin and metalloprotease) family of proteins possess multi-domain structures composed of a signal peptide, a prodomain, a metalloprotease domain, a disintegrin-like domain, a cysteine rich domain, an epidermal growth factor-like domain, a transmembrane domain and cytoplasmic tail.
X, Lu, D, Lu, M F, Scully, V V, Kakkar
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The ADAM gene family: surface proteins with adhesion and protease activity
Trends in Genetics, 2000An ADAM is a transmembrane protein that contains a disintegrin and metalloprotease domain and, therefore, it potentially has both cell adhesion and protease activities. Currently, the ADAM gene family has 29 members, although the function of most ADAM gene products is unknown.
P, Primakoff, D G, Myles
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ADAMs family members as amyloid precursor protein α‐secretases
Journal of Neuroscience Research, 2003AbstractIn the non‐amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is cleaved within the amyloid‐β domain by α‐secretase precluding deposition of intact amyloid‐β peptide. The large ectodomain released from the cell surface by the action of α‐secretase has several neuroprotective properties.
Allinson, Tobias M. J. +3 more
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ADAM proteins, their ligands, and clinical implications
Neurology, 2012AD= : Alzheimer disease; ADAM= : A disintegrin and metalloproteinase; ADEAF= : autosomal dominant partial epilepsy with auditory features; ADTLE= : autosomal dominant familial temporal lobe epilepsy; APP= : amyloid precursor protein; EPTP= : epitempin; Kv= : voltage-gated potassium; LGI= : leucine-rich, glioma inactivated; LRR= :
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Endothelial metalloprotease-disintegrin protein (ADAM) is implicated in angiogenesis in vitro
Angiogenesis, 1998Recently two metalloproteinase, disintegrin, cysteine proteins (MDCs), also called ADAMs were identified on endothelial cells. However the role of these ADAMs are not defined on these cells. In order to elucidate whether ADAMs associated with endothelial cells could be involved in angiogenesis, we have tested the effect of an inhibitor of ADAM (GL ...
V, Trochon +8 more
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Protein synthesis during germination of Peronospora tabacina (Adam) conidia
Archives of Biochemistry and Biophysics, 1971The characteristics of an in vitro amino acid-incorporating system prepared from germinated Peronospora tabacina conidia are described. Material sedimenting at 20,000 g and at 117,000 g was found to possess significant amino acid-incorporating activity. Although germination is accompanied by an increase in the activity of both these fractions, if
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The ADAMs family of proteins: from basic studies to potential clinical applications
Thrombosis and Haemostasis, 2003SummaryThe ADAMs are a family of membrane proteins possessing a disintegrin and metalloprotease domain. Currently,34 members are known to exist. Approximately 50% of the ADAMs contain a metalloprotease-like domain and some of these have been shown to possess protease activity.
Michael J, Duffy +3 more
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2003
Publisher Summary Since their discovery about a decade ago, some very intriguing insights into the function of a few Anchored Metalloprotease-Disintegrin Proteins (ADAMs) have emerged. They have been linked to a role in cell–cell interactions as potential integrin ligands and in the cleavage and release and, in several cases, activation of membrane ...
J David, Becherer, Carl P, Blobel
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Publisher Summary Since their discovery about a decade ago, some very intriguing insights into the function of a few Anchored Metalloprotease-Disintegrin Proteins (ADAMs) have emerged. They have been linked to a role in cell–cell interactions as potential integrin ligands and in the cleavage and release and, in several cases, activation of membrane ...
J David, Becherer, Carl P, Blobel
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ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
American Journal of Physiology-Cell Physiology, 2006A disintegrin and metalloprotease (ADAM) is a membrane-anchored metalloprotease implicated in the ectodomain shedding of cell surface proteins, including the ligands for epidermal growth factor (EGF) receptors (EGFR)/ErbB. It has been well documented that the transactivation of the EGFR plays critical roles for many cellular functions, such as ...
Haruhiko, Ohtsu +2 more
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Induction of new adam related protein from treated human Chang-liver cells
Molecular Biology, 2010Chang-liver cells is a cell line generated from human liver tissue, which is often used in scientific research. ADAMs are a family of proteins that consist of multi-domains, possess multi-functions and play a central role in normal or abnormal physiological conditions, such as regeneration and tumorigenesis. To investigate the expression and functional
C R, Wang +5 more
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