Results 11 to 20 of about 67,779 (149)

ADAM 12 Cleaves Extracellular Matrix Proteins and Correlates with Cancer Status and Stage [PDF]

Journal of Biological Chemistry, 2004
ADAM 12 is a member of a family of disintegrin-containing metalloproteases that have been implicated in a variety of diseases including Alzheimer's disease, arthritis, and cancer. We purified ADAM 12 from the urine of breast cancer patients via Q-Sepharose anion exchange and gelatin-Sepharose affinity chromatography followed by protein identification ...
Susan Pories, Marsha Moses, David Zurakowski   +2 more
exaly   +4 more sources

Characterization of the V4 and T1 polymorphism of the ADAM33 gene and its association with the development of asthma

Revista de la Facultad de Medicina Humana, 2021
Objective: To determine the association between the presence of V4 polymorphisms of the ADAM33 gene and asthma disease and to describe the frequency of T1 polymorphism in patients from a hospital in the Lambayeque region. Materials and methods: Design of
Clarisa Carolina Arrascue Vega, Rossana Menendez Nuñez, Walter Gutierrez Celestino-Segura, Luis Miguel Serquén López, Alain Eduard Monsalve Mera   +4 more
doaj   +1 more source

Adaptive gradient scaling: integrating Adam and landscape modification for protein structure prediction

BMC Bioinformatics
Background Protein structure prediction is one of the most important scientific problems, on the one hand, it is one of the NP-hard problems, and on the other hand, it has a wide range of applications including drug discovery and biotechnology ...
Vitalii Kapitan, Michael Choi
doaj   +3 more sources

Role of ADAM and ADAMTS proteases in pathological tissue remodeling

Cell Death Discovery, 2023
Pathological tissue remodeling is closely associated with the occurrence and aggravation of various diseases. A Disintegrin And Metalloproteinases (ADAM), as well as A Disintegrin And Metalloproteinase with ThromboSpondin motifs (ADAMTS), belong to zinc ...
Zhaoni Wang, Wanshan Li, Shixing Chen, Xiao Xiao Tang   +3 more
doaj   +1 more source

ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages

Journal of Immunology Research, 2022
A disintegrin and metalloprotease 10 (ADAM-10), a member of the ADAM protease family, has biological activities related to TNF-α activation, cell adhesion, and migration, among other functions.
Yan Jiang, Qiming Gong, Jinmei Huang, Yuanxun Gong, Qiang Tang, Dalong Wei, Qianli Tang, Jingjie Zhao, Jian Song, Lingzhang Meng   +9 more
doaj   +1 more source

The ADAMs family of metalloproteases: multidomain proteins with multiple functions [PDF]

Genes & Development, 2003
The ADAMs family of transmembrane proteins belongs to the zinc protease superfamily. Members of the family have a modular design, characterized by the presence of metalloprotease and integrin receptor-binding activities, and a cytoplasmic domain that in many family members specifies binding sites for various signal transducing proteins.
Darren F, Seals, Sara A, Courtneidge
openaire   +2 more sources

Detection of the ADAM proteins in the ejaculated bovine sperm

International journal of health sciences, 2022
The current study aimed to detect specific types of ADAM proteins in the bovine sperm. Histology study of tissue of male reproduction was involved with testis, head, body, and the tail of the epididymis. Results showed that the testis composed of the parenchyma of testis contained the seminiferous tubules which are surrounded by two layers externally ...
Asseel Yassin, Hazem Almhanna, Nabeel Abd Murad AL-Mamoori   +2 more
openaire   +1 more source

Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of β-Catenin, BRG1, and KDM4

Frontiers in Cell and Developmental Biology, 2020
A disintegrin and metalloproteinase (ADAM) family of proteins play versatile roles in cancer development and progression. In the present study, we investigated the role of ADAM proteins in colorectal cancer (CRC) cell migration and invasion focusing on ...
Lina Sun, Lina Sun, Baoyu Chen, Jiahao Wu, Chao Jiang, Zhiwen Fan, Yifei Feng, Yifei Feng, Yong Xu, Yong Xu   +9 more
doaj   +1 more source

Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein [PDF]

Journal of Biological Chemistry, 2009
The cellular prion protein (PrP(C)) is essential for the pathogenesis and transmission of prion diseases. PrP(C) is bound to the plasma membrane via a glycosylphosphatidylinositol anchor, although a secreted, soluble form has also been identified.
Taylor, David R, Parkin, Edward T, Cocklin, Sarah L, Ault, James R, Ashcroft, Alison E, Turner, Anthony J, Hooper, Nigel M   +6 more
openaire   +4 more sources

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions. [PDF]

PLoS ONE, 2015
A disintegrin and metalloproteinases (ADAMs) constitute a protein family essential for extracellular signaling and regulation of cell adhesion. Catalytic activity of ADAMs and their predicted potential for Src-homology 3 (SH3) domain binding show a ...
Iivari Kleino, Annika Järviluoma, Jussi Hepojoki, Ari Pekka Huovila, Kalle Saksela   +4 more
doaj   +1 more source