Results 101 to 110 of about 3,308,144 (197)
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients
, 2017 Mian Zeng, Qingui Chen, Wenjie Liang, Wanmei He, Haichong Zheng, Chunrong Huang Department of Medical Intensive Care Unit, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Background: Impaired renal function is often neglected ...
Chen QG +5 more
core
ADAMTS-1 and Aggrecan are both in the nucleus.
, 2016 (A) Colocalization of ADAMTS-1 and aggrecan. ADAMTS-1 (red), Aggrecan (green) and Nuclei (blue). Aggrecan is found in nuclei and cytoplasm and is colocalized with ADAMTS-1 in cell nucleolus (white arrows) in MCF7 and MDA-MB-231. Scale bar: 5 μm.
Ruy G. Jaeger (618268) +4 more
core +1 more source
The FEBS Journal, Volume 293, Issue 13, Page 3954-3972, July 2026.Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre +2 more
wiley +1 more source
Multi-step binding of ADAMTS-13 to von Willebrand factor
, 2009 Background: ADAMTS-13 proteolytic activity is controlled by the conformation of its substrate, von Willebrand factor (VWF), and changes in the secondary structure of VWF are essential for efficient cleavage.
Anderson, PJ +4 more
core +1 more source
血浆ADAMTS-13活性和NLR在急性肺血栓栓塞症中的诊断价值
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的探究急性肺血栓栓塞症（PTE）患者血浆血管性血友病因子（vWF）活性、血管性血友病因子裂解酶（ADAMTS-13）活性、中性粒细胞计数与淋巴细胞计数比率（NLR）健康对照组的表达差异，探究ADAMTS-13活性、NLR对于PTE患者的诊断意义。方法共纳入急性PTE患者64例及健康对照者30例，收集相关临床数据并采用酶联免疫吸附试验（ELISA）检测血浆ADAMTS-13活性、vWF活性，分析比较ADAMTS-13活性、vWF活性的组间差异及其与其他临床指标的相关性，绘制受试者工作特征曲线（ROC ...
胡子旋, 何婉媚, 曾勉
doaj
The FASEB Journal, Volume 40, Issue 11, 15 June 2026.During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu +9 more
wiley +1 more source
Acquired ADAMTS-13 Deficiency in Pediatric Patients with Severe Sepsis
, 2012 [[abstract]]We studied the state of ultralarge von Willebrand factor (ULVWF) proteolysis in 21 pediatric patients with severe sepsis and found that the overall group of patients had moderately reduced ADAMTS-13 activity, but 31% had severe enzymatic ...
Nguyen, Trung C. ; Liu, Anne; Liu, Li; Ball, Chalmette; Choi, Hiuwan; May, William S. ; Aboulfatova, Khatira; Bergeron, Angela L. ; Dong, Jing-fei
core
Общая реаниматология, 2011 Objective: to study the role of a tissue factor pathway inhibitor (TFPI), the metalloproteinase ADAMTS-13, and its inhibitor in the pathogenesis of acute respiratory distress syndrome (ARDS) in A/H1N1 influenza. Subjects and methods.
E. V. Prutkina +4 more
doaj +1 more source
Effect of ADAMTS-13 on cerebrovascular microthrombosis and neuronal injury after experimental subarachnoid hemorrhage [PDF]
, 2014 Background: Microthrombosis and reactive inflammation contribute to neuronal injury after sub- arachnoid hemorrhage (SAH). ADAMTS-13 cleaves von Willebrand factor multimers, and inhibits thrombus formation and, seemingly, inflammatory reactions ...
Iwasaki, K +9 more
core +1 more source