Results 91 to 100 of about 3,308,144 (197)

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, Volume 293, Issue 13, Page 4043-4063, July 2026.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

ADAMTS -1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes [PDF]

, 2006
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) enzymes are a recently described group of metalloproteinases. The substrates degraded by ADAMTS-1, -4 and -5 suggests that they play a role in turnover of extracellular matrix in the
Woodroofe, N., Surr, J., Allan, S., Stock, C. J., Cross, A. K., Haddock, G., Buttle, D. J., Bunning, R. A.   +7 more
core   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, Volume 293, Issue 13, Page 3848-3864, July 2026.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock

, 2007
BACKGROUND: Insufficient control of von Willebrand factor (VWF) multimer size as a result of severely deficient ADAMTS-13 activity results in thrombotic thrombocytopenic purpura associated with microvascluar thrombosis and platelet consumption, features ...
Zeerleder, S, Zeerleder, S., ten Cate, H, Wuillemin, W. A., Romani de Wit, T, Hack, C. E., van Mourik, J A, Kessler, P., Lämmle, B., Reitsma, P H, Kremer Hovinga, J A, Romani de Wit, T., Kremer Hovinga, J. A., van Mourik, J. A., Wuillemin, W A, Lämmle, B, Kessler, P, ten Cate, H., Reitsma, P. H., Hack, C E   +19 more
core   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

ADAMTS-13: diagnóstico de laboratorio

, 2020
ADAMTS-13 es una desintegrina y metaloproteasa, zinc y calcio dependiente, codificada en el cromosoma humano 9q34. Su rol primario es clivar los multímeros ultra grandes del factor de Von Willebrand (ULVWF) originando sus diferentes formas moleculares ...
Aranda Aranda, Federico Manuel, Larrañaga, Gabriela de, Lencinas, Gisela, Peres, Silvia   +3 more
core  

Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment

The FEBS Journal, Volume 293, Issue 13, Page 4085-4097, July 2026.
MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley   +1 more source

ADAMTS-1 is present on nuclei of invasive ductal carcinoma cells but not on luminal cells of normal breast tissue.

, 2016
(A) Immunohistochemistry shows ADAMTS-1 inside the nucleus of cancer cells (arrows pointed to dot-like structures). Cells under division or stromal-like cells do not present ADAMTS-1 (arrowheads).
Ruy G. Jaeger (618268), Suély V. Silva (3233223), Maíra A. Lima (3233220), Vanessa M Freitas (3233226), Nathalie Cella (2889740)   +4 more
core   +1 more source

Severe ADAMTS-13 deficiency without hemolysis as a cause of cryptogenic stroke: A single center case series

Journal of Stroke and Cerebrovascular Diseases
Introduction: Cerebral Infarction due to Severe ADAMTS-13 Deficiency (CISAD) remains an underrecognized cause of cryptogenic stroke. Despite the absence of classic hematologic features, CISAD confers a risk of recurrent ischemic events if not promptly ...
Johanna Seiden, MD, MPH, Juan Felipe Daza-Ovalle, MD, Zhengrui Xiao, MD, Olga Rubalsky, MD, Irina Murakhovskaya, MD, Ellen Friedman, MD, Kathryn Kirchoff-Torres, MD, Daniel Labovitz, MD, MS, Charles Esenwa, MD, MS   +8 more
doaj   +1 more source