Results 151 to 160 of about 12,658,346 (176)

The amelioration of cartilage degeneration by ADAMTS-5 inhibitor delivered in a hyaluronic acid hydrogel

Biomaterials, 2014
Degradation of proteoglycan is the key early event in the development of osteoarthritis (OA). The aggrecanase ADAMTS-5 has been identified as the major enzyme responsible for the degradation and thus is an attractive therapeutic target for OA. However, currently there is no report on using an ADAMTS-5 inhibition strategy for OA treatment.
Pengfei, Chen, Shouan, Zhu, Yanyan, Wang, Qin, Mu, Yan, Wu, Qingqing, Xia, Xiaolei, Zhang, Heng, Sun, Jiadong, Tao, Hu, Hu, Ping, Lu, Hongwei, Ouyang   +11 more
openaire   +2 more sources

Impact Of Activating Adamts-5 In Cartilage-related Degenerative Disorders

2010
The 2010 World Forum for Spine Research (WFSR 2010): The Intervertebral Disc, Montreal, Canada, 5-8 July 2010.
Fosang, AMANDA, McCulloch, DANIEL, Cheung, KMC, Nagy, ANDRAS, Sze, KL, Chan, D   +5 more
openaire   +4 more sources

Screening, isolation and characterisation of antibodies that block aggrecanase activity of ADAMTS-5

2013
A Disintegrin and Metalloproteinase with ThromboSpondin Motif (ADAMTS)-5 is considered to play a key role in degradation of aggrecan during the progression of osteoarthritis (OA). Thus, ADAMTS-5 inhibitors are emerging as potential disease-modifying OA drugs.
openaire   +2 more sources

The IL-1β/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis

Journal of molecular medicine, 2016
Q. Ji, Xiaojie Xu, Qiang Zhang, L. Kang, Yameng Xu, Ke Zhang, Ling Li, Yingchun Liang, T. Hong, Q. Ye, Yan Wang   +10 more
semanticscholar   +2 more sources

MiR‐132‐3p regulates ADAMTS‐5 expression and promotes chondrogenic differentiation of rat mesenchymal stem cells

Journal of Cellular Biochemistry, 2018
Xiaozhong Zhou, Di-xin Luo, Hongtao Sun, Y. Qi, Wang-yang Xu, Xun-jie Jin, Chao Li, Zhousheng Lin, Guitao Li   +8 more
semanticscholar   +1 more source

Peptide Vaccine Against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima Hyperplasia

Circulation, 2023
Wei Kong, Qingbo Xu, Yiting Jia
exaly  

Role of ADAMTS-1 in Atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Peter Brodin, Birgitta Rosengren
exaly  

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

Osteoarthritis and Cartilage, 2008
Mary B Goldring, S B Abramson, S B Abramson   +2 more
exaly  

ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage

Matrix Biology, 2004
Carl R Flannery, Edward R Lavallie, Andrew J Dörner   +2 more
exaly  

Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: Comparative analyses with ADAMTS-5, -9, -16 and -18

Biochimica Et Biophysica Acta - General Subjects, 2006
Carl R Flannery, Edward R Lavallie, Elisabeth A Morris   +2 more
exaly