Results 131 to 140 of about 12,658,346 (176)

Selection and characterization of DNA aptamers inhibiting a druggable target of osteoarthritis, ADAMTS-5.

Biochimie, 2022
There is a critical need for the development of more potent inhibitors for osteoarthritis (OA) therapy given the poor life quality of arthritis patients.
Yuanyuan Yu, Mengping Liu, Vanessa Choi, Y. Cheung, J. Tanner   +4 more
semanticscholar   +3 more sources

Inhibition of ADAMTS-5: the right target for osteoarthritis?

Osteoarthritis and Cartilage, 2021
A. Latourte, P. Richette
semanticscholar   +3 more sources

Targeting ADAMTS-5 for osteoarthritis: promise and challenges.

Osteoarthritis and Cartilage
A. Bay‐Jensen
semanticscholar   +3 more sources

Human glioblastomas overexpress ADAMTS-5 that degrades brevican

Acta Neuropathologica, 2005
Selective cleavage of the Glu395-Ser396 bond of brevican, one of the major proteoglycans in adult brain tissues, is thought to be important for glioma cell invasion. Our previous biochemical study demonstrated that ADAMTS-4, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, has such an activity.
Yasunori Okada, Mitsutoshi Nakada, Junkoh Yamashita   +2 more
exaly   +3 more sources

DNA demethylation of promoter region orchestrates SPI‐1‐induced ADAMTS‐5 expression in articular cartilage of osteoarthritis mice

Journal of Cellular Physiology, 2023
Osteoarthritis (OA) is one of the most prevalent joint diseases in aged people and characterized by articular cartilage degeneration, synovial inflammation, and abnormal bone remodeling.
Zhixin Liu, Tongxin Lu, Liang Ma, Yuankai Zhang, Deqiang Li   +4 more
semanticscholar   +1 more source

ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis

Journal of Cellular Biochemistry, 2011
Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multi-factorial, the cartilage destruction appears to be a result of uncontrolled proteolytic extracellular matrix destruction.
Priyanka, Verma, Krishna, Dalal
exaly   +3 more sources

Purification and Activity Determination of ADAMTS-4 and ADAMTS-5 and Their Domain Deleted Mutants. [PDF]

Methods in molecular biology, 2019
A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-4 (ADAMTS-4) and ADAMTS-5 are zinc-dependent metalloproteinases that are involved in the maintenance of cartilage extracellular matrix (ECM) and are currently considered the major aggrecanases in the development of osteoarthritis.
M. M. Fowkes, N. Lim
semanticscholar   +3 more sources

Characterization of the promoter in ADAMTS‐5 (aggrecanase‐2)

International Journal of Experimental Pathology, 2004
Introduction  Loss of aggrecan metabolites from the cartilage matrix into the surrounding synovial fluid have allowed for identification of two major cleavage sites within aggrecan: Asn341–Phe342 and Glu373–Ala374 peptide bonds. Proteolysis at the Glu373–Ala374 bond has been specifically attributed to ADAMTS‐4 and ADAMTS‐5.
M.R. Heming, S.D. Wainwright, B. Caterson, C.E. Hughes   +3 more
openaire   +1 more source

Long non-coding RNA XIST regulates chondrogenic differentiation of synovium-derived mesenchymal stem cells from temporomandibular joint via miR-27b-3p/ADAMTS-5 axis.

Cytokine, 2020
OBJECTIVE Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative disease in jaw joint, accompanied by articular cartilage destruction.
Ye-Ling Zhu, Ren Li, L. Wen
semanticscholar   +1 more source

ADAMTS-4 and ADAMTS-5

2006
Osteoarthritis (OA) is characterized by articular cartilage erosion as a consequence of proteolytic cleavage of its two major functional macromolecules, type II collagen and aggrecan. Aggrecan degradation in OA and rheumatoid arthritis is attributed to cleavage at the Glu373-Ala374 bond by the aggrecanases.
Anne-Marie Malfait, Micky Tortorella, Elizabeth Arner   +2 more
openaire   +1 more source