Results 111 to 120 of about 15,848 (207)

Inhibition of MMPs and ADAM/ADAMTS

Biochemical Pharmacology, 2019
Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc-dependent endopeptidases that play a critical role in the destruction of extracellular matrix proteins and, the shedding of membrane-bound receptor molecules in various forms of arthritis and ...
openaire   +3 more sources

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.

, 2008
ADAMTS-4 (aggrecanase-1) and ADAMTS-5 (aggrecanase-2) are multidomain metalloproteinases belonging to the ADAMTS family. We have previously reported that human ADAMTS-5 has much higher aggrecanolytic activity than human ADAMTS-4.
Troeberg, Linda, Nakamura, Hiroyuki, Nagase, H, Nakamura, H, Lim, Ngee Han, Lim, NH, Fushimi, Kazunari, Nagase, Hideaki, Fushimi, K, Troeberg, L   +9 more
core   +1 more source

Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients

, 2017
Mian Zeng, Qingui Chen, Wenjie Liang, Wanmei He, Haichong Zheng, Chunrong Huang Department of Medical Intensive Care Unit, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Background: Impaired renal function is often neglected ...
Chen QG, Zheng HC, Huang CR, Zeng M, He WM, Liang WJ   +5 more
core  

Von Willebrand factor cleaving protease (ADAMTS-13) in 123 patients with connective tissue diseases (systemic lupus erythematosus and systemic sclerosis)

Haematologica, 2003
BACKGROUND AND OBJECTIVES: Autoantibodies inactivating the von Willebrand factor (VWF) cleaving protease, ADAMTS-13, are among the most frequent causes of thrombotic thrombocytopenic purpura (TTP).
PM Mannucci, M Vanoli, I Forza, MT Canciani, R Scorza   +4 more
doaj  

Comparative assessment of changes ADAMTS-13/von Willebrand factor axis in singleton and bichorial biamniotic pregnancy

Акушерство, гинекология и репродукция
Aim: to compare changes in the ADAMTS-13 metalloproteinase/von Willebrand factor (vWF) axis in pregnant women with spontaneous or following in vitro fertilization (IVF) singleton and bichorial biamniotic pregnancies.Materials and Methods.
F. Е. Yagubova, V. O. Bitsadze, N. V. Samburova, J. Kh. Khizroeva, A. D. Makatsariya   +4 more
doaj   +1 more source

Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus

Medicina
A disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7) belongs to the family of metalloproteinases that contributes to tissue homeostasis during morphogenesis and reproduction. These metalloproteinases regulate various cell functions
Asimina Ganotopoulou, Emmanouil Korakas, Loukia Pliouta, Aikaterini Kountouri, Sotirios Pililis, Stamatios Lampsas, Ignatios Ikonomidis, Loukianos S. Rallidis, Athanasia Papazafiropoulou, Andreas Melidonis, Vaia Lambadiari   +10 more
doaj   +1 more source

The role of ADAMTS-4 and ADAMTS-1 in angiogenesis

, 2012
Endothelial cells (ECs) form the innermost layer of all blood vessels, and their function and behaviour are important in angiogenesis. VEGF is the most potent angiogenic factor stimulating EC proliferation, migration, and differentiation as well as ...
Hsu, Yi-Ping
core  

The Relationship Between ADAMTS‐4 and ADAMTS‐5 Enzyme Levels in Patients With Degenerative Disc Disease: A Prospective Biochemical Study

JOR Spine
Study Design Prospective biochemical study of comparison of A Disintegrin and Metalloproteinase with Thrombospondin motifs‐4 (ADAMTS‐4) and A Disintegrin and Metalloproteinase with Thrombospondin motifs 5 (ADAMTS5) levels in preoperative and ...
Cansu Tuncer, Emin Mehmet Eminoğlu, Ömer Emre Yağlı, Gülçin Baş, Ahmet Sancar Topal, Ece Onur, Habib Özdemir, Şemsi Güliz Yılmaz, Gülgün Yılmaz Ovalı, Cüneyt Temiz   +9 more
doaj   +1 more source

ADAMTS expression in laryngeal cancer

, 2018
Ο καρκίνος το λάρυγγα είναι ένας από τους λιγότερο συνήθεις καρκίνους. Ωστόσο, τα συμπτώματά του δεν γίνονται γρήγορα αντιληπτά από τους ασθενείς και η επίσκεψη στον λαρυγγολόγο γίνεται σε προχωρημένο στάδιο.
Κακάτσου, Κωνσταντίνα
core  

Splenectomy in relapsing and plasma-refractory acquired thrombotic thrombocytopenic purpura

Haematologica, 2004
BACKGROUND AND OBJECTIVES: Acquired thrombotic thrombocytopenic purpura (TTP) is often due to autoantibodies inhibiting ADAMTS-13 activity resulting in impaired processing of very large von Willebrand factor multimers.
JA Kremer Hovinga, JD Studt, F Demarmels Biasiutti, M Solenthaler, L Alberio, C Zwicky, S Fontana, BM Taleghani, A Tobler, B Laemmle   +9 more
doaj