Results 91 to 100 of about 15,848 (207)

Histopathologic Analysis of the Morpho‐Functional Zones of the Human Acetabular Labrum

Clinical Anatomy, Volume 39, Issue 7, Page 787-800, October 2026.
ABSTRACT The structural and functional adaptation of soft tissues to mechanical load controls their ability to withstand injury and influences their capacity for healing. Similar to the knee meniscus, the acetabular labrum exhibits zonal differences in mechanical load distribution, resulting in distinct regions with unique structural and functional ...
Abdulaziz A. Alomiery, Andrew C. Hall, Thomas H. Gillingwater, Afaf Alsolami, Abduelmenem Alashkham   +4 more
wiley   +1 more source

The role of ADAMTS genes in preeclampsia

Journal of Turkish Society of Obstetric and Gynecology, 2016
Preeclampsia is a complex disease that increases both maternal and fetal morbidity and mortality in both developed and developing countries. It complicates around 5-10% of all pregnancies..The pathophysiology of preeclampsia includes both maternal and fetal/placental factors.
Gökdemir, İrem Eda, Evliyaoğlu, Özlem, Çoşkun, Buğra   +2 more
openaire   +2 more sources

Structural and Functional Characteristics of ADAMTS-4 and ADAMTS-5: A Review

Natural Systems and Resources, 2020
ADAMTS-4 and -5 are aggrecanases that are involved in the development of osteoarthrosis, one of the most common diseases at the moment, due to which a large number of people suffer annually. By some estimates, 9.6% of men and 18% of women over the age of 60 have symptomatic osteoarthrosis.
Anastasia Korchagina, Lyudmila Derevshchikova   +1 more
openaire   +1 more source

Expression of COL6A1 in Tumor Matrix of Cholangiocarcinoma and Its Mechanism of Tumor Progression

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Cholangiocarcinoma (CCA), a malignant tumor originating from the bile duct epithelial cells, is characterized by aggressive invasion and poor prognosis. Abnormal remodeling of the tumor microenvironment plays a pivotal role in its disease progression.
Weibin Zhang, Chongshi Gao, Chongzhou Lan, Jia Dong, Boxing Xu, Yingmei Li, Jin Dai, Baitong Che, Cheng Li, Gang Dong, Yunfei Wu, Bo Li, Cheng Yang, Lingmei Kong   +13 more
wiley   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

ADAMTS proteases in vascular biology

Matrix Biology, 2015
ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases comprise the most recently discovered branch of the extracellular metalloenzymes. Research during the last 15years, uncovered their association with a variety of physiological and pathological processes including blood coagulation, tissue repair, fertility, arthritis and ...
Rodríguez-Manzaneque, Juan Carlos, Fernández-Rodríguez, Rubén, Rodríguez-Baena, Francisco Javier, Iruela-Arispe, M Luisa   +3 more
openaire   +4 more sources

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source

Expression of ADAMTS-4 and ADAMTS-5 in joint cartilage.

, 2013
A. Immunostaining for ADAMTS-4 in cartilage. Bars represent the percentage of positive cells. B. Immunostaining for ADAMTS-5 in cartilage. C. 40× magnification of ADAMTS-4 & ADAMTS-5 expression in the tibial joint cartilage in Sham operated knees (a–g ...
Martine Esther Cohen-Solal (329495), Philippe Orcel (54852), Thomas Funck-Brentano (329489), Eric Hay (5652436), Marie-Dominique Ah Kioon (329491), Didier Hannouche (329493), Frédéric Lioté (11471), Hilène Lin (329490), Rémy Nizard (5648860), Marie-Christine de Vernejoul (329494), Corinne Schiltz (329492)   +10 more
core   +1 more source

ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan [PDF]

, 2000
A disintegrin-like and metalloproteinase with thrombospondin type I motifs-1 (ADAMTS-1) is an extracellular matrix-anchored metalloproteinase. In this study we have demonstrated that ADAMTS-1 is able to cleave a major cartilage proteoglycan, aggrecan.
Nakamura, Hiroyuki, Kouji Matsushima, Masayuki Miyasaka, Kuno, Kouji, Hiroshi Ohno, Yasunori Okada, Ohno, Hiroshi, Matsushima, Kouji, Okada, Yasunori, Kawashima, Hiroto, Miyasaka, Masayuki, Kouji Kuno, Hiroyuki Nakamura, Hiroto Kawashima   +13 more
core   +1 more source

Analyses of role of ADAMTS-1 in ovarian function by using ADAMTS-1 null mice [PDF]

, 2006
ADAMTS-1は、プロテオグリカン分解活性を有するメタロプロテアーゼであり、腎盂尿管移行部組織の構築や雌の生殖機能に重要である。我々は卵巣機能におけるADAMTS-1の役割を明らかにするために、ADAMTS-1-/-マウスの卵巣機能の異常について調べた。まずADAMTS-1-/-マウスでは、過排卵条件下での排卵数が顕著に減少するが、これは(1)成熟卵胞の減少と、(2)成熟した卵胞の排卵率の低下の2つの段階で起こっていることがわかり、ADAMTS ...
久野, 耕嗣, 88086, 40242565
core   +1 more source