Results 71 to 80 of about 12,128 (176)

ADAMTS-1 and ADAMTS-4 Levels Are Elevated in Thoracic Aortic Aneurysms and Dissections [PDF]

The Annals of Thoracic Surgery, 2013
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) is a recently identified family of extracellular metalloproteinases that has been shown to participate in tissue destruction. We hypothesized that ADAMTS-1 and ADAMTS-4 expression is increased in aortic tissues from patients with thoracic aortic aneurysms and dissections.We ...
Pingping, Ren, Lin, Zhang, Gaiping, Xu, Laura C, Palmero, Paul T, Albini, Joseph S, Coselli, Ying H, Shen, Scott A, LeMaire   +7 more
openaire   +2 more sources

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

The role of ADAMTS genes in preeclampsia

Journal of Turkish Society of Obstetric and Gynecology, 2016
Preeclampsia is a complex disease that increases both maternal and fetal morbidity and mortality in both developed and developing countries. It complicates around 5-10% of all pregnancies..The pathophysiology of preeclampsia includes both maternal and fetal/placental factors.
Gökdemir, İrem Eda, Evliyaoğlu, Özlem, Çoşkun, Buğra   +2 more
openaire   +2 more sources

Structural and Functional Characteristics of ADAMTS-4 and ADAMTS-5: A Review

Natural Systems and Resources, 2020
ADAMTS-4 and -5 are aggrecanases that are involved in the development of osteoarthrosis, one of the most common diseases at the moment, due to which a large number of people suffer annually. By some estimates, 9.6% of men and 18% of women over the age of 60 have symptomatic osteoarthrosis.
Anastasia Korchagina, Lyudmila Derevshchikova   +1 more
openaire   +1 more source

The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration

Orthopaedic Surgery, Volume 18, Issue 9, Page 1804-1818, September 2026.
The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou, Jingyi Cai, Weijian Zhu, Sirui Zhou, Liling Zhou, Yiyao Pei, Gang Wu   +6 more
wiley   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, Volume 13, Issue 48, 28 August 2026.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

ADAMTS proteases in vascular biology

Matrix Biology, 2015
ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases comprise the most recently discovered branch of the extracellular metalloenzymes. Research during the last 15years, uncovered their association with a variety of physiological and pathological processes including blood coagulation, tissue repair, fertility, arthritis and ...
Rodríguez-Manzaneque, Juan Carlos, Fernández-Rodríguez, Rubén, Rodríguez-Baena, Francisco Javier, Iruela-Arispe, M Luisa   +3 more
openaire   +4 more sources

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, Volume 13, Issue 48, 28 August 2026.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

The Journal of biological chemistry, 2007
Aggrecanases have been characterized as proteinases that cleave the Glu373-Ala374 bond of the aggrecan core protein, and they are multidomain metalloproteinases belonging to the ADAMTS (adamalysin with thrombospondin type 1 motifs) family. The first aggrecanases discovered were ADAMTS-4 (aggrecanase 1) and ADAMTS-5 (aggrecanase 2).
Gendron, Christi, Kashiwagi, Masahide, Ngee, Han Lim, Enghild, Jan J.; id_orcid 0000-0001-9292-9172, Thøgersen, Ida B., Hughes, Clare, Caterson, Bruce, Nagase, Hideaki   +7 more
openaire   +3 more sources

Pediatric stroke and ADAMTS genes

Blood, 2012
In a study of 270 children with ischemic stroke and their parents, Arning and colleagues report associations with genetic variants in several genes of the ADAMTS family ...
F. R. Rosendaal, F. Peyvandi
openaire   +4 more sources