Results 111 to 120 of about 20,502 (253)

A rare case of renal thrombotic microangiopathy associated with Castleman’s disease [PDF]

, 2017
BACKGROUND: Castleman’s disease (CD) is an uncommon, heterogeneous lympho-proliferative disorder leading to high circulating levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF).
Chen, Ying Maggie, Cossey, L. Nicholas, Liapis, Helen, Mutneja, Ahubha   +3 more
core   +2 more sources

ADAMTS13 and VWF activities guide individualized caplacizumab treatment in patients with aTTP.

Blood Advances, 2020
Introduction of the nanobody caplacizumab was shown to be effective in the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in the acute setting.
L. Völker, J. Kaufeld, Wolfgang A. Miesbach, Sebastian Brähler, M. Reinhardt, Lucas Kühne, A. Mühlfeld, A. Schreiber, J. Gaedeke, M. Tölle, W. Jabs, Fedai Özcan, S. Markau, M. Girndt, F. Bauer, T. Westhoff, H. Felten, M. Hausberg, M. Brand, J. Gerth, M. Bieringer, M. Bommer, S. Zschiedrich, J. Schneider, S. Elitok, A. Gawlik, A. Gäckler, A. Kribben, V. Schwenger, U. Schoenermarck, M. Roeder, J. Radermacher, J. Bramstedt, A. Morgner, R. Herbst, Ana Harth, S. Potthoff, C. von Auer, R. Wendt, H. Christ, Paul T. Brinkkoetter, J. Menne   +41 more
semanticscholar   +1 more source

Adult‐Onset Still's Disease Complicated by Secondary Hemophagocytic Lymphohistiocytosis: A Case Report

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Adult‐onset Still's disease (AOSD) is a rare autoinflammatory disorder characterized by fever, rash, joint pain, and elevated ferritin levels. Systemic inflammation can trigger an exaggerated immune response, leading to secondary hemophagocytic lymphohistiocytosis (HLH).
Vasileios Patriarcheas, Vasiliki Gougoula, Michail Makris, Athanasios Penopoulos, Eleftheria Ztriva, Stavroula Bountola, Theodoros Dimitroulas, Christos Savopoulos, Georgia Kaiafa   +8 more
wiley   +1 more source

VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma

BMC Gastroenterology, 2019
Background To investigate the von Willebrand factor to ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma (HCC) in cirrhosis.
Hiroaki Takaya, Tadashi Namisaki, Mitsuteru Kitade, Kosuke Kaji, Keisuke Nakanishi, Yuki Tsuji, Naotaka Shimozato, Kei Moriya, Kenichiro Seki, Yasuhiko Sawada, Soichiro Saikawa, Shinya Sato, Hideto Kawaratani, Takemi Akahane, Ryuichi Noguchi, Masanori Matsumoto, Hitoshi Yoshiji   +16 more
doaj   +1 more source

Conformational activation of ADAMTS13 [PDF]

, 2014
A disintegrin and metalloprotease with thrombospondin motifs 13 (ADAMTS13) is a metalloprotease that regulates von Willebrand factor (VWF) function. ADAMTS13-mediated proteolysis is determined by conformational changes in VWF, but also may depend on its ...
Collins, RF, Crawley, JTB, Deforche, L, Lane, DA, Luken, BM, Phillips, R, South, K, Thomas, M, Vanhoorelbeke, K   +8 more
core   +1 more source

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12

Glia, Volume 73, Issue 12, Page 2464-2482, December 2025.
Main Points Transcriptionally, P2RY12‐deficient microglia show heightened metabolic activity, iron handling and oxidative stress at baseline. Upon LPS challenge, impaired glutathione antioxidant responses suggest increased vulnerability to ferroptosis. ABSTRACT Microglia are the resident immune cells of the CNS.
Aida Oryza Lopez‐Ortiz, Madison Doceti, JaQuinta Thomas, Abigayle Duffy, Morgan Coburn, Akhabue K. Okojie, Audrey Lee, Elizabeth Aidita Sou, Alban Gaultier, Ukpong B. Eyo   +9 more
wiley   +1 more source

Soluble C5b‐9 (sC5b‐9) in Pediatrics—A Clinical Assessment

Journal of Clinical Laboratory Analysis, Volume 39, Issue 23, December 2025.
The sc5b9 assay is a simple laboratory‐developed test that can be used in specific patients to monitor the course of disease, severity, or response to therapy. Future studies using this assay, which show excellent adaptability to a clinical laboratory, will reveal the multiple uses of testing for complement activation.
Ridwan B. Ibrahim, Radwa Almamoun, Sarah E. Sartain, Sridevi Devaraj   +3 more
wiley   +1 more source

Concentration and Subclass Distribution of Anti-ADAMTS13 IgG Autoantibodies in Different Stages of Acquired Idiopathic Thrombotic Thrombocytopenic Purpura

Frontiers in Immunology, 2018
BackgroundThe acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying deficiency of the ADAMTS13 protease is caused by autoantibodies, predominantly of the IgG isotype.
György Sinkovits, Ágnes Szilágyi, Péter Farkas, Dóra Inotai, Anikó Szilvási, Attila Tordai, Katalin Rázsó, Marienn Réti, Zoltán Prohászka   +8 more
doaj   +1 more source

ADAMTS13 and von Willebrand factor assessment in steady state and acute vaso‐occlusive crisis of sickle cell disease

Research and Practice in Thrombosis and Haemostasis, 2021
Background Sickle cell disease (SCD) is characterized by vaso‐occlusive crisis (VOC), acute chest syndrome (ACS) and multiorgan failure (MOF) complicated by thrombosis.
Julien Demagny, Aurélie Driss, Alain Stepanian, Nadia Anguel, Louis Affo, Damien Roux, Anoosha Habibi, Sandrine Benghezal, Sophie Capdenat, Paul Coppo, Françoise Driss, Agnès Veyradier   +11 more
doaj   +1 more source

Rotational Thromboelastometry (ROTEM) Versus Conventional Coagulation Tests in Cirrhosis: Can We Reduce Plasma Transfusion Without ROTEM?

Journal of Clinical Laboratory Analysis, Volume 39, Issue 24, December 2025.
ROTEM showed a strong correlation with conventional coagulation tests (CCTs) but failed to assess re‐balanced hemostasis. Similar to ROTEM, using higher CCT thresholds may help reduce unnecessary plasma transfusions before invasive procedures. ABSTRACT Background Periprocedural rotational thromboelastometry (ROTEM) could reduce transfusions while ...
Nuanrat Cheerasiri, Ratchaneekorn Jantasing, Rapat Pittayanon, Ponlapat Rojnuckarin   +3 more
wiley   +1 more source