Results 111 to 120 of about 12,875 (250)

A Systematic Review of Vascular Injuries: A Review of Petechiae, Purpura, and Ecchymosis in Critical Situations Following COVID‐19 Vaccination

Health Science Reports, Volume 8, Issue 3, March 2025.
ABSTRACT Background and Aims Vascular injuries characterized by petechiae, purpura, and ecchymosis have been reported as potential adverse effects following COVID‐19 vaccination. This study aims to identify the characteristics of patients experiencing vascular injuries postvaccination and to outline key clinical considerations.
Yasamin Kalantari, Seyed Mohamad Sadegh Mirahmadi, Sanam Alilou, Sara Sadeghi, Zeinab Aryanian, Alireza Jafarzadeh, Azadeh Goodarzi   +6 more
wiley   +1 more source

Open ADAMTS13 Conformation in Immune-Mediated Thrombotic Thrombocytopenic Purpura Is Induced By Anti-ADAMTS13 Autoantibodies and Corresponds with an Ongoing ADAMTS13 Pathology

Blood, 2018
Abstract Background. Deficient ADAMTS13 activity (TS13:act <10%) induced by anti-ADAMTS13 autoantibodies (autoAbs) causes immune-mediated thrombotic thrombocytopenic purpura (iTTP). Recently we showed that an open ADAMTS13 conformation is characteristic for acute iTTP patients, while folded ADAMTS13 was found in 78% of iTTP patients ...
Roose, Elien, Schelpe, An-Sofie, Tellier, Edwige, Sinkovits, Gyorgy, Kaplanski, Gilles, Le Besnerais, Maëlle, Mancini, Ilaria, Vandeputte, Nele, Vandenbulcke, Aline, Pareyn, Inge, Voorberg, J. J., Greinacher, Andreas, Benhamou, Ygal, Deckmyn, Hans, Fijnheer, Rob, Prohászka, Zoltán, Peyvandi, Flora, Coppo, Paul, de Meyer, Simon F., Veyradier, Agnes, Vanhoorelbeke, Karen   +20 more
openaire   +7 more sources

Reduced ADAMTS13 Activity in Correlation with Pathophysiology, Severity, and Outcome of COVID-19: A Retrospective Observational Study

International Journal of Infectious Diseases, 2022
Background: Low ADAMTS13 activity has been suggested to be an interplaying factor in the pathogenesis of COVID-19, considering that it is a thromboinflammatory disease with high risk of microthrombosis.
Wael Hafez, Mohamad Azzam Ziade, Arun Arya, Husam Saleh, Sara Ali, Srinivasa Raghu Rao, Osman Fdl Alla, Mohamed Ali, Mouhamad Al Zouhbi, Ahmed Abdelrahman   +9 more
doaj  

International Council for Standardization in Haematology (ICSH) recommendations for laboratory measurement of ADAMTS13

International Journal of Laboratory Hematology, 2020
This guidance document was prepared on behalf of the International Council for Standardization in Haematology (ICSH), by the ADAMTS13 Assay Working Group, which comprises an international group of both clinical and laboratory experts.
I. Mackie, I. Mancini, J. Muia, J. K. Kremer Hovinga, S. Nair, S. Machin, R. Baker   +6 more
semanticscholar   +1 more source

Hairpin and allosteric regulation in ADAMTS13 [PDF]

Blood, 2019
In this issue of Blood , Muia et al 1 and Zhu et al, 2 using complementary approaches, provide important insights into the structure and function of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin-1 repeats, member 13), identifying critical structural features and interactions that allosterically regulate its proteolytic activity ...
openaire   +2 more sources

Thrombotic thrombocytopenic purpura - a disease with multiple organ manifestations. Diagnostic and therapeutic difficulties in clinical practice

Journal of Education, Health and Sport, 2018
Introduction: Thrombotic thrombocytopenic purpura (TTP) is a rare, heterogeneous and life-threating disease requiring prompt differential diagnosis. The most common form of that disease is idiopathic form affects usually young adults.
Magdalena Szydełko, Joanna Szydełko, Agnieszka Szymczyk, Dominika Szymczyk, Magdalena Chomczyńska, Monika Podhorecka   +5 more
doaj   +1 more source

Inflammation, von Willebrand factor, and ADAMTS13.

Blood, 2018
Increasing evidence indicates that inflammation can cause thrombosis by a von Willebrand factor (VWF)-mediated mechanism that includes endothelial activation, secretion of VWF, assembly of hyperadhesive VWF strings and fibers, cleavage by ADAMTS13, and ...
Junmei Chen, D. Chung
semanticscholar   +1 more source

Development of a protease-resistant ADAMTS13 to improve stability against proteolytic degradation

Blood Advances
: Recombinant ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) was recently approved by the US Food and Drug Administration for the treatment of heritable thrombotic thrombocytopenic purpura, and preclinical ...
Veronica DeYoung, Rex Huang, Hasam Madarati, Rida Malik, Peter Andrisani, Cherie Teney, Colin A. Kretz   +6 more
doaj  

Prolonged Exposure to Caplacizumab as Rescue Therapy in Refractory Immune Thrombotic Thrombocytopenic Purpura

Journal of Blood Medicine, 2023
George M Rodgers,1 Misa Berndt,2 Megan Fonteno,3 Jeffrey A Gilreath2,4 1Division of Hematology and Hematologic Malignancies Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT, USA; 2Sugarhouse Hematology, University of Utah, Salt ...
Rodgers GM, Berndt M, Fonteno M, Gilreath JA   +3 more
doaj  

Structure of von Willebrand Factor-cleaving Protease (ADAMTS13), a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura [PDF]

, 2001
X. Long Zheng, Dominic W. Chung, Thomas K. Τakayama, Elaine M. Majerus, J. Evan Sadler, Kazuo Fujikawa   +5 more
openalex   +1 more source