Results 31 to 40 of about 12,875 (250)

Associations between the von Willebrand Factor—ADAMTS13 Axis, Complement Activation, and COVID-19 Severity and Mortality

Thrombosis and Haemostasis, 2022
Background  Endothelial and complement activation were both associated with immunothrombosis, a key determinant of COVID-19 severity, but their interrelation has not yet been investigated.
G. Sinkovits, M. Réti, V. Müller, Z. Iványi, J. Gal, L. Gopcsa, P. Reményi, B. Szathmáry, B. Lakatos, J. Szlávik, I. Bobek, Z. Prohászka, Z. Förhécz, B. Mező, D. Csuka, L. Hurler, E. Kajdácsi, L. Cervenak, P. Kiszel, T. Masszi, I. Vályi-Nagy, Z. Prohászka   +21 more
semanticscholar   +1 more source

ADAMTS13, VWF, and Endotoxin Are Interrelated and Associated with the Severity of Liver Cirrhosis via Hypercoagulability

Journal of Clinical Medicine, 2022
ADAMTS13 specifically cleaves the multimeric von Willebrand factor (VWF), and an imbalance between ADAMTS13 activity (ADAMTS13:AC) and VWF antigen (VWF:Ag) levels is associated with the severity of liver cirrhosis (LC).
Hiroaki Takaya, T. Namisaki, Shohei Asada, S. Iwai, T. Kubo, Junya Suzuki, Masahide Enomoto, Y. Tsuji, Yukihisa Fujinaga, Norihisa Nishimura, Yasuhiko Sawada, K. Kaji, H. Kawaratani, K. Moriya, Takemi Akahane, M. Matsumoto, H. Yoshiji   +16 more
semanticscholar   +1 more source

Role of ADAMTS13, VWF and F8 genes in deep vein thrombosis.

PLoS ONE, 2021
BackgroundWe previously described the association between rare ADAMTS13 single nucleotide variants (SNVs) and deep vein thrombosis (DVT). Moreover, DVT patients with at least one rare ADAMTS13 SNV had a lower ADAMTS13 activity than non-carriers.AimsTo ...
Maria Teresa Pagliari, Andrea Cairo, Marco Boscarino, Ilaria Mancini, Emanuela Pappalardo, Paolo Bucciarelli, Ida Martinelli, Frits R Rosendaal, Flora Peyvandi   +8 more
doaj   +2 more sources

Evidence of protective effects of recombinant ADAMTS13 in a humanized model of sickle cell disease

Haematologica, 2022
Sickle cell disease (SCD) is an inherited red blood cell disorder that occurs worldwide. Acute vaso-occlusive crisis is the main cause of hospitalization in patients with SCD.
P. Rossato, E. Federti, A. Matte, H. Glantschnig, F. Canneva, M. Schuster, S. Coulibaly, G. Schrenk, D. Voelkel, M. Dockal, B. Plaimauer, I. Andolfo, A. Iolascon, H. Rottensteiner, H. Gritsch, F. Scheiflinger, W. Hoellriegl, L. De Franceschi   +17 more
semanticscholar   +1 more source

Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura: a short review and update

Platelets, 2023
ADAMTS13 is a plasma metalloprotease with the primary function of cleaving VWF to maintain hemostasis. Circulating ADAMTS13 is in the closed conformation until blood vessel injury triggers a VWF-dependant activation to the open active form of the protein.
Zoe Markham-Lee, Neil V. Morgan, Jonas Emsley   +2 more
doaj   +1 more source

ADAMTS13 conformations and mechanism of inhibition in immune thrombotic thrombocytopenic purpura

Journal of Thrombosis and Haemostasis, 2022
ADAMTS13, a plasma metalloprotease that cleaves von Willebrand factor, is crucial for normal hemostasis. Acquired autoantibody‐mediated deficiency of plasma ADAMTS13 results in a potentially fatal blood disorder, immune thrombotic thrombocytopenic ...
Konstantine Halkidis, X. L. Zheng
semanticscholar   +1 more source

Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance

Blood Advances, 2022
Key Points ADAMTS13 sSNVs affect mRNA thermodynamic stability and may disturb mRNA-splicing sites. Synonymous variations may affect ADAMTS13 function and contribute to large variability in protein expression levels in healthy individuals.
Katarzyna I. Jankowska, Douglas Meyer, David Holcomb, Jacob Kames, N. Hamasaki-Katagiri, Upendra K. Katneni, R. Hunt, J. Ibla, C. Kimchi-Sarfaty   +8 more
semanticscholar   +1 more source

ADAMTS13 regulation of VWF multimer distribution in severe COVID‐19

Journal of Thrombosis and Haemostasis, 2021
Consistent with fulminant endothelial cell activation, elevated plasma von Willebrand factor (VWF) antigen levels have been reported in patients with COVID‐19.
Soracha E. Ward, Helen Fogarty, Ellie Karampini, M. Lavin, S. Schneppenheim, R. Dittmer, Hannah Morrin, S. Glavey, C. Ní Cheallaigh, C. Bergin, I. Martín-Loeches, P. Mallon, G. Curley, R. Baker, U. Budde, J. O’Sullivan, James S O' Donnell   +16 more
semanticscholar   +1 more source

Phenotypic expression of ADAMTS13 in glomerular endothelial cells.

PLoS ONE, 2011
BackgroundADAMTS13 is the physiological von Willebrand factor (VWF)-cleaving protease. The aim of this study was to examine ADAMTS13 expression in kidneys from ADAMTS13 wild-type (Adamts13⁺/⁺) and deficient (Adamts13⁻/⁻) mice and to investigate the ...
Ramesh Tati, Ann-Charlotte Kristoffersson, Anne-Lie Ståhl, Matthias Mörgelin, David Motto, Simon Satchell, Peter Mathieson, Minola Manea-Hedström, Diana Karpman   +8 more
doaj   +1 more source

Diagnosis of thrombotic thrombocytopenic purpura

Терапевтический архив, 2020
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease, disease, characterised by microangiopathic hemolytic anaemia, consumption thrombocytopenia, and organ dysfunction.
G. M. Galstyan, E. E. Klebanova
doaj   +1 more source