Results 31 to 40 of about 13,808 (210)

ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study [PDF]

, 2016
Aims/hypothesis: ADAMTS13 is a protease that breaks down von Willebrand factor (VWF) multimers into smaller, less active particles. VWF has been associated with an increased risk of incident type 2 diabetes mellitus.
Dehghan, A. (Abbas), Franco, O.H. (Oscar), Herpt, T.W. (Thijs) van, Hoek, M. (Mandy) van, Hofman, A. (Albert), Ikram, M.A. (Arfan), Leebeek, F.W.G. (Frank), Ligthart, S. (Symen), Maat, M.P.M. (Moniek) de, Sijbrands, E.J.G. (Eric), Vries, P.S. (Paul) de   +10 more
core   +4 more sources

Mechanistic Studies on ADAMTS13 Catalysis [PDF]

Biophysical Journal, 2008
The zinc-protease a disintegrin-like and metalloprotease with thrombospondin type I repeats (ADAMTS13) cleaves the Tyr(1605)-Met(1606) peptide bond of von Willebrand factor (VWF), avoiding the accumulation of ultra large VWF multimers. Hydrolysis by ADAMTS13 of a VWF analog (Asp(1596)-Arg(1668) peptide, fluorescence energy transfer substrate [FRETS ...
Di Stasio, Enrico, Lancellotti, Stefano, Peyvandi, F., Palla, R., Mannucci, P. M., De Cristofaro, Raimondo   +5 more
openaire   +4 more sources

Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions

Frontiers in Medicine, 2017
Platelet recruitment to sites of vascular injury is mediated by von Willebrand factor (VWF). The shear-induced unraveling of ultra-large VWF multimers causes the formation of a “stringlike” conformation, which rapidly recruits platelets from the ...
Kathleen S. Garland, Kathleen S. Garland, Stéphanie E. Reitsma, Stéphanie E. Reitsma, Toshiaki Shirai, Jevgenia Zilberman-Rudenko, Erik I. Tucker, Erik I. Tucker, David Gailani, András Gruber, András Gruber, Owen J. T. McCarty, Cristina Puy   +12 more
doaj   +1 more source

Degradation of two novel congenital TTP ADAMTS13 mutants by the cell proteasome prevents ADAMTS13 secretion [PDF]

, 2016
INTRODUCTION: Over 150 mutations have been identified in the ADAMTS13 gene in patients with congenital thrombotic thrombocytopenic purpura (TTP). The majority of these (86%), lead to reduced (
Garagiola, I, Machin, S, Mackie, I, Peyvandi, F, Underwood, M   +4 more
core   +1 more source

Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. [PDF]

, 2009
The activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease is low in several conditions, including HELLP (haemolysis, elevated liver enzymes, and low platelet count) syndrome.
Bõze, Tamás, Cervenak, László, Derzsy, Zoltán, Gombos, Tímea, Hársfalvi, Jolán, Makó, Veronika, Molvarec, Attila, Prohászka, Zoltán, Rigó, János, Udvardy, Miklós László   +9 more
core   +1 more source

ADAMTS13 and microvascular thrombosis [PDF]

Expert Review of Cardiovascular Therapy, 2006
Interaction between platelet and von Willebrand factor, a circulating adhesive glycoprotein, is essential for hemostasis under the high shear environments of arterioles and capillaries. If unregulated, this interaction may lead to unwarranted platelet thrombosis.
openaire   +2 more sources

Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia [PDF]

, 2018
Low ADAMTS13 activity is associated with an increased risk of cardiovascular disease, which is generally attributed to its proteolytic effects on Von Willebrand factor (VWF). Cardiovascular health is an important determinant of cognitive decline, but the
Boender, J. (Johan), Franco, O.H. (Oscar), Ikram, M.A. (Arfan), Ikram, M.K. (Kamran), Koudstaal, P.J. (Peter), Leebeek, F.W.G. (Frank), Maat, M.P.M. (Moniek) de, Sonneveld, M.A.H. (Michelle), Vries, P.S. (Paul) de, Wolters, F.J. (Frank)   +9 more
core   +1 more source

Special delivery for ADAMTS13 [PDF]

Blood, 2015
In this issue of Blood, using a transgenic mouse model, Pickens et al describe that ectopic expression of ADAMTS13, exclusively in platelets, is able to provide effective protection in murine models of arterial thrombosis and thrombotic thrombocytopenic purpura (TTP ...
openaire   +2 more sources

ADAMTS13 activity and antigen during therapy and follow-up of patients with idiopathic thrombotic thrombocytopenic purpura: correlation with clinical outcome

Haematologica, 2011
Background The assay for ADAMTS13 activity helps clinicians to confirm the clinical diagnosis of idiopathic thrombotic thrombocytopenic purpura. The clinical value of testing for the antigen level of ADAMTS13 protein is, however, less clear.Design and ...
Shangbin Yang, Ming Jin, Shili Lin, Spero Cataland, Haifeng Wu   +4 more
doaj   +1 more source

ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis

Journal of Neuroinflammation, 2020
Background ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13) plays a vital role in preventing microvascular thrombosis and inflammation.
Kaili Lu, Lan Liu, Xiaofeng Xu, Fei Zhao, Jiangshan Deng, Xin Tang, Xiuzhe Wang, Bing-Qiao Zhao, Xiaojie Zhang, Yuwu Zhao   +9 more
doaj   +1 more source