Results 121 to 130 of about 5,511,471 (226)

Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs [PDF]

, 2017
Increases in prothrombin time (PT) and international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF), yet a wide heterogeneity in clotting abnormalities exists.
A Clauss, A Gatt, A Tripodi, A Zambruni, AF Riddell, AO Spiel, B Agarwal, B Agarwal, B Agarwal, DJ Antoine, DJ Antoine, E Gehrie, EA Sankey, FB Mayr, GC Hugenholtz, H Schochl, HJ Tsai, J Vaquero, JG O’Grady, JH Griffin, KC Lee, KC Lee, L Rinaldi, LA Baker, M Habib, M Senzolo, M Yamaguchi, MJ McPhail, P Chowdary, R Jalan, R Kanel von, RT Stravitz, RT Stravitz, SJ Deventer van, SJ Munoz, SR Ostrowski, T Lisman, T Lisman, TE Warkentin, V Rewari   +39 more
core   +3 more sources

A Systematic Review of Vascular Injuries: A Review of Petechiae, Purpura, and Ecchymosis in Critical Situations Following COVID‐19 Vaccination

Health Science Reports, Volume 8, Issue 3, March 2025.
ABSTRACT Background and Aims Vascular injuries characterized by petechiae, purpura, and ecchymosis have been reported as potential adverse effects following COVID‐19 vaccination. This study aims to identify the characteristics of patients experiencing vascular injuries postvaccination and to outline key clinical considerations.
Yasamin Kalantari, Seyed Mohamad Sadegh Mirahmadi, Sanam Alilou, Sara Sadeghi, Zeinab Aryanian, Alireza Jafarzadeh, Azadeh Goodarzi   +6 more
wiley   +1 more source

Refining the Protein-Protein Interactome using Gene Expression Data [PDF]

arXiv, 2010
Proteins interact with other proteins within biological pathways, forming connected subgraphs in the protein-protein interactome (PPI). Proteins are often involved in multiple biological pathways which complicates interpretation of interactions between proteins.
arxiv  

ADAMTS13 protects mice against renal ischemia-reperfusion injury by reducing inflammation and improving endothelial function.

AJP - Renal Physiology, 2019
Acute kidney injury (AKI) is a serious condition without efficient therapeutic options. Recent studies have indicated that recombinant human a disintegrin and metalloprotease with thrombospondin motifs 13 (rhADAMTS13) provides protection against ...
Suhan Zhou, Shan Jiang, Jie Guo, Nan Xu, Qin Wang, Gensheng Zhang, Liang Zhao, Qin Zhou, Xiaodong Fu, Lingli Li, A. Patzak, M. Hultström, E. Lai   +12 more
semanticscholar   +1 more source

Clinicopathological Characteristics and Outcomes of Lupus Nephritis Patients With Thrombocytopenia: A Single‐Center Retrospective Study

Immunity, Inflammation and Disease, Volume 13, Issue 3, March 2025.
LN patients with thrombocytopenia showed a higher SLE disease activity index. The prognosis was similar between LN patients with and without thrombocytopenia. Anemia was a risk factor for death in LN patients with thrombocytopenia. ABSTRACT Objectives The objective of this study is to analyze and summarize the clinical characteristics and prognosis of ...
Hui Diao, Yuting Fan, Di Kang, Zhiqing Chen, Yuewen Lu, Xiamin Huang, Xi Xia, Wei Chen   +7 more
wiley   +1 more source

Protein token: a dynamic unit in protein interactions [PDF]

arXiv, 2018
In this study, we introduced a new unit, named "protein token", as a dynamic protein structural unit for protein-protein interactions. Unlike the conventional structural units, protein token is not based on the sequential or spatial arrangement of residues, but comprises remote residues involved in cooperative conformational changes during protein ...
arxiv  

von Willebrand's disease: a report from a meeting in the Åland islands [PDF]

, 2012
von Willebrand's disease (VWD) is probably the most common bleeding disorder, with some studies indicating that up to 1% of the population may have the condition.
Bergamaschini, Berntorp, Berntorp, Berntorp, Berntorp, Berntorp, Borel-Derlon, Bowen, Dean, Dunkley, Federici, Federici, Flood, Franchini, Goodeve, Hyatt, Iorio, Klenk, Laffan, Larsson, Lassila, Lethagen, Mannucci, Mannucci, Matsui, McGrath, Nichols, Nilsson, Pasi, Rodeghiero, Rodeghiero, Ruggeri, Ruggeri, Sadler, Sadler, Sarji, Soulier, Stray-Pedersen, Sweeney, Titani, Tosetto, Von Willebrand, Von Willebrand, Von Willebrand, Williams, Witmer, Zhang   +46 more
core   +1 more source

Coagulation Factors and White Matter Hyperintensities in Middle‐Aged Women With and Without Migraine and Ischemic Stroke

European Journal of Neurology, Volume 32, Issue 3, March 2025.
ABSTRACT Background Migraine increases the risk of ischemic stroke and white matter hyperintensities (WMH), especially in women. Underlying shared mechanisms may include endothelial activation and hypercoagulability. We assessed these markers in middle‐aged women with and without migraine and ischemic stroke to explore their role in WMH development ...
Mariam Ali, Nelleke van der Weerd, Hendrikus J. A. van Os, Annelise E. Wilms, Ghislaine Holswilder, Katie M. Linstra, Thijs W. van Harten, Suzanne C. Cannegieter, Bob Siegerink, Bart J. M. van Vlijmen, L. Renee Ruhaak, Nyika D. Kruyt, Mark C. Kruit, Antoinette Maassen Van Den Brink, Gisela M. Terwindt, Marieke J. H. Wermer, The CREW Consortium   +16 more
wiley   +1 more source

Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK [PDF]

, 2018
Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased
Cardwell, J M, Holm, L P, Jepson, R E, O'Neill, D G, Stevens, K B, Walker, D J   +5 more
core   +1 more source

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation.

Blood, 2019
The metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats member 13) prevents microvascular thrombosis by cleaving von Willebrand factor (VWF) within platelet-rich thrombi, and cleavage depends on allosteric ...
J. Muia, Jian Zhu, Suellen C. Greco, K. Vanhoorelbeke, G. Gupta, L. A. Westfield, J. E. Sadler   +6 more
semanticscholar   +1 more source