Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria [PDF]
, 2016 Adherence of infected erythrocytes to vascular endothelium causes acute endothelial cell (EC) activation during Plasmodium falciparum infection.
Brophy, Teresa M +9 more
core +1 more source
Anemia, 2011 Sickle cell anemia (SCA) is a common hemolytic disorder caused by a gene mutation in the β-globin subunit of hemoglobin (Hb) and affects millions of people.
Zhou Zhou +2 more
doaj +1 more source
The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding. [PDF]
, 2016 Multimerin 1 (MMRN1) is a massive, homopolymeric protein that is stored in platelets and endothelial cells for activation-induced release. In vitro, MMRN1 binds to the outer surfaces of activated platelets and endothelial cells, the extracellular matrix (
Bihan, Dominique +7 more
core +3 more sources
Rare Variants in the ADAMTS13 Von Willebrand Factor–Binding Domain Contribute to Pediatric Stroke
Circulation: Cardiovascular Genetics, 2016 Background—Recently, we reported a gene network of ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) genes as central component of the genetic risk contributing to pediatric stroke.
M. Stoll +6 more
semanticscholar +1 more source
Thrombotic Thrombocytopenic Purpura Revisited: Upshaw Schulman Syndrome in a 20-Year-Old Male [PDF]
, 2012 Case Report A 20-year-old male with no significant past medical history presented to an outside hospital with a two-week history of progressive fatigue, malaise and decreased appetite. Prior to these events, he had been in his usual state of health with
Peiris, MD, Niluk, Wang, MD, Judy
core +2 more sources
From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity
Infection International, 2018 Autoantibodies (AAbs) against von Willebrand factor (vWF)-cleaving protease ADAMTS13 causally relate to thrombotic thrombocytopenic purpura (TTP). How anti-ADAMTS13 AAbs are generated is unknown.
D. Kanduc
semanticscholar +1 more source
An Unusual Case of Rapidly Progressive Hyperbilirubinemia
Case Reports in Pediatrics, 2013 We present an unusual case of hyperbilirubinemia with rapid early progression leading to bilirubin encephalopathy in a term neonate. Despite early recognition and intervention, the total serum bilirubin reached a maximum level of 39 mg/dL at 32 hours of ...
Kimberly M. Thornton +7 more
doaj +1 more source
Regulation of ADAMTS13 by proteolitic enzymes
, 2007 Imperial Users ...
Lam, Jonathan Kai Yan +1 more
core
Clinical Dilemma in the Treatment of a Patient with Microangiopathic Haemolytic Anaemia, Thrombocytopaenia and Severe Hypertension [PDF]
, 2010 While haemolytic uraemic syndrome in children is predominantly associated with Shiga toxin -producing Escherichia coli (typically 0157:H7), some cases occur without associated diarrhoea, or as the manifestation of an underlying disorder other than ...
Castro, I, Gomes, D, Viegas, V
core
PROTEOLYTIC PROCESSING OF VON WILLEBRAND FACTOR BY ADAMTS13 AND LEUKOCYTE PROTEASES-rev1-MJHID-2013
Mediterranean Journal of Hematology and Infectious Diseases, 2014 ADAMTS13 is a 190 kDa zinc protease encoded by a gene located on chromosome 9q34. This protease specifically hydrolyzes von Willebrand factor (VWF) multimers, thus causing VWF size reduction.
Raimondo De Cristofaro
doaj