Results 51 to 60 of about 5,529,499 (207)

Expression of ADAMTS13 in human endometrium and its potential role in recurrent pregnancy loss

Archives of Medical Science, 2021
The mechanisms underlying the pathogenesis of recurrent pregnancy loss (RPL) and the effective approaches to treat this disease still remain vague and absent. Proteinases of ADAMTS family play important roles in embryonic growth and development.
Yun Feng, Xue-yin Li, Xi Chen, Mengling Zhao, Qian Wang, Jing Bai, M. Mao, R. Guo   +7 more
semanticscholar   +1 more source

Performance related factors are the main determinants of the von Willebrand factor response to exhaustive physical exercise [PDF]

, 2014
Background: Physical stress triggers the endothelium to release von Willebrand Factor (VWF) from the Weibel Palade bodies. Since VWF is a risk factor for arterial thrombosis, it is of great interest to discover determinants of VWF response to physical ...
A Casonato, AM Keightley, AO Spiel, BC Creighton, CH Widberg, DD Wagner, DJ Pinsky, EM Bladbjerg, Frank W. G. Leebeek, G Lippi, G Lippi, G Rock, GY Lip, H Tanaka, I Martinelli, IM Lee, J Myers, J Ribeiro, J Stakiw, Janine E. van Loon, JB Hansen, JC Souto, JE Sadler, JE van Loon, JL Ribeiro, JP Giblin, JR Day, L Gallinaro, LA Sporn, M de Lange, M Small, MC van Schie, MD Delp, Michelle A. H. Sonneveld, MJ Hollestelle, Moniek P. M. de Maat, MP Reilly, MS El-Sayed, MS El-Sayed, N Hickson, NL Smith, NL Smith, O Wu, PH Whincup, PJ Harvey, RA Claus, RA Reiter, RG Wieberdink, S Kanaji, S Lethagen, Stephan F. E. Praet, T Mayadas, Toshiyuki Miyata, V Daidone, YY Zhang   +54 more
core   +7 more sources

ADAMTS13 levels in a plasma-derived FVIII concentrate: A potential therapeutic option for patients with congenital thrombotic thrombocytopenic purpura

Thrombosis Update, 2022
Introduction: Treatment of congenital thrombotic thrombocytopenic purpura (cTTP), a disease characterized by the congenital deficiency of ADAMTS13, remains a challenge as there are no specific treatments available yet, other than therapy based on the use
Filippo Mori, Ilaria Nardini, Silvia Nannizzi, Roberto Crea, Prasad Mathew, Nicole Ziliotto, Alessandro Gringeri   +6 more
doaj  

Factor XI/ADAMTS13 complexes are quantitatively insignificant in human plasma [PDF]

, 2007
Reportedly, complexes between factor XI and ADAMTS13 are detected with a commercial ADAMTS13/FXI ELISA kit in plasma and are decreased in thrombotic thrombocytopenic purpura (TTP).
Anderson, Patricia J, Feys, Hendrik B, Gailani, David, Gao, Weiqiang, Majerus, Elaine M, Sadler, J. Evan, Vanhoorelbeke, Karen   +6 more
core   +2 more sources

ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study [PDF]

, 2016
Aims/hypothesis: ADAMTS13 is a protease that breaks down von Willebrand factor (VWF) multimers into smaller, less active particles. VWF has been associated with an increased risk of incident type 2 diabetes mellitus.
Dehghan, A. (Abbas), Franco, O.H. (Oscar), Herpt, T.W. (Thijs) van, Hoek, M. (Mandy) van, Hofman, A. (Albert), Ikram, M.A. (Arfan), Leebeek, F.W.G. (Frank), Ligthart, S. (Symen), Maat, M.P.M. (Moniek) de, Sijbrands, E.J.G. (Eric), Vries, P.S. (Paul) de   +10 more
core   +3 more sources

Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome [PDF]

, 2010
Thrombotic microangiopathies (TMAs) are pathological conditions characterized by generalized microvascular occlusion by platelet thrombi, thrombocytopenia, and microangiopathic hemolytic anemia.
Mastroianni Kirsztajn, Gianna, Polito, Maria Goretti   +1 more
core   +2 more sources

Cloning, Expression and Inhibitory Effects on Lewis Lung Carcinoma Cells of rAj-Tspin from Sea Cucumber (Apostichopus japonicus)

Molecules, 2021
In recent years, sea cucumber has become a favorite healthcare food due to its characteristic prevention of cardiovascular diseases, suppression of tumors, as well as enhancement of immunity.
Rong Qiao, Rong Xiao, Zhong Chen, Jingwei Jiang, Chenghua Yuan, Shuxiang Ning, Jihong Wang, Zunchun Zhou   +7 more
doaj   +1 more source

Thrombotic microangiopathy and associated renal disorders [PDF]

, 2012
Thrombotic microangiopathy (TMA) is a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion.
Barbour, T, Cohney, S, Hughes, P, Johnson, S   +3 more
core   +1 more source

The Effect of IL-6-Primed Platelets on ADAMTS13-Mediated Clearance of Platelet-Bearing ULVWF and Its Mechanism

, 2021
Inflammation is an essential contributing factor in the development of thrombosis. Using a microfluidic flow chamber, we investigated how the proinflammatory cytokine interleukin 6 (IL-6) affects the cleavage of platelet-bearing ultra-large VWF (ULVWF)
Hyun-Jeong Kim, Jing-fei Dong, Yejin Song, Hyo-Il Jung, Jaewoo Song   +4 more
semanticscholar   +1 more source

Intracranial aneurysm’s association with genetic variants, transcription abnormality, and methylation changes in ADAMTS genes [PDF]

PeerJ, 2020
Purpose The development of intracranial aneurysm (IA) has been linked to genetic factors. The current study examines the potential role of genes encoding disintegrin and metalloproteinase using thrombospondin motifs (ADAMTS) in IA development.
Shi Chen, Mengqi Li, Wenqiang Xin, Shengze Liu, Linfei Zheng, Yan Li, Mengyao Li, Mengxiong Zhan, Xinyu Yang   +8 more
doaj   +2 more sources