Results 61 to 70 of about 5,529,499 (207)

Expert Statements on the Standard of Care in Critically Ill Adult Patients With Atypical Hemolytic Uremic Syndrome. [PDF]

, 2017
A typical hemolytic uremic syndrome (aHUS) presents similarly to thrombotic thrombocytopenic purpura (TTP) and other causes or conditions with thrombotic microangiopathy (TMA), such as disseminated intravascular coagulation or sepsis.
Abroug, F., Azoulay, E., Benoit, D., Eggimann, P., Galstian, G., Garnacho-Montero, J., Knoebl, P., Rusinova, K., Scully, M., von Bergwelt-Baildon, M., Wendon, J.   +10 more
core   +3 more sources

Prognostic value of von Willebrand factor levels in patients with metastatic melanoma treated by immune checkpoint inhibitors

Journal for ImmunoTherapy of Cancer, 2023
Background An increased incidence of thrombotic complications associated with an increased mortality rate has been observed under immune checkpoint inhibition (ICI).
Stefan W Schneider, Klaus Pantel, Christoffer Gebhardt, Robin Reschke, Christian Mess, Julia-Christina Stadler, Laura Keller, Alexander T Bauer, Julian Koett, Glenn Geidel, Isabel Heidrich, Sabine Vidal-y-Sy, Antje Andreas, Carlotta Stramaglia, Mark Sementsov, Wiebcke Haberstroh, Benjamin Deitert, Inka Lilott Hoehne, Thomas Haalck   +18 more
doaj   +1 more source

Antibodies that conformationally activate ADAMTS13 allosterically enhance metalloprotease domain function.

Blood Advances, 2020
Plasma ADAMTS13 circulates in a folded conformation that is stabilized by an interaction between the central Spacer domain and the C-terminal CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains ...
A. Schelpe, A. Petri, E. Roose, I. Pareyn, H. Deckmyn, S. D. De Meyer, J. Crawley, K. Vanhoorelbeke   +7 more
semanticscholar   +1 more source

Detection of Plasma Protease Activity Using Microsphere-Cytometry Assays with E. coli Derived Substrates: VWF Proteolysis by ADAMTS13. [PDF]

PLoS ONE, 2015
Protease levels in human blood are often prognostic indicators of inflammatory, thrombotic or oncogenic disorders. The measurement of such enzyme activities in substrate-based assays is complicated due to the low prevalence of these enzymes and steric ...
Shobhit Gogia, Chi Y Lo, Sriram Neelamegham   +2 more
doaj   +1 more source

Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK [PDF]

, 2018
Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased
Cardwell, J M, Holm, L P, Jepson, R E, O'Neill, D G, Stevens, K B, Walker, D J   +5 more
core   +1 more source

Long noncoding RNA GCH1 mediates mitophagy via the PTEN‐induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract illustrates the role of lncRNA‐GCH1 in regulating mitophagy and its downstream effects on chondrocyte dysfunction and cartilage degradation in osteoarthritis (OA). Elevated lncRNA‐GCH1 stabilizes PINK1 protein, enhancing mitophagy and mitochondrial turnover.
Gang Zeng, Yujun Sun, Taihe Liu, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Weidong Song, Yue Ding   +8 more
wiley   +1 more source

Quantitative Systems Pharmacology Modeling of Platelet Responses to Recombinant ADAMTS13 in Patients With Congenital Thrombotic Thrombocytopenic Purpura

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra‐rare, life‐threatening thrombotic microangiopathy caused by a severe inherited deficiency of ADAMTS13, a von Willebrand factor (VWF) cleaving enzyme. Inadequate clinical endpoint data often make it challenging to statistically power clinical trials in ultra‐rare diseases ...
Cameron McBride, Jiaolong Jiang, Zhiwei Zhang, John Tolsma, Parth Patwari, Björn Mellgård, Majid Vakilynejad, Indranil Bhattacharya, Andy Z. X. Zhu   +8 more
wiley   +1 more source

Structural basis of type 2A von Willebrand disease investigated by molecular dynamics simulations and experiments. [PDF]

PLoS ONE, 2012
The hemostatic function of von Willebrand factor is downregulated by the metalloprotease ADAMTS13, which cleaves at a unique site normally buried in the A2 domain.
Gianluca Interlandi, Minhua Ling, An Yue Tu, Dominic W Chung, Wendy E Thomas   +4 more
doaj   +1 more source

Multi-lectin Affinity Chromatography and Quantitative Proteomic Analysis Reveal Differential Glycoform Levels between Prostate Cancer and Benign Prostatic Hyperplasia Sera. [PDF]

, 2018
Currently prostate-specific antigen is used for prostate cancer (PCa) screening, however it lacks the necessary specificity for differentiating PCa from other diseases of the prostate such as benign prostatic hyperplasia (BPH), presenting a clinical need
Adusumilli, Ravali, Brooks, James D, Kullolli, Majlinda, Mallick, Parag, Pitteri, Sharon J, Tanimoto, Cheylene, Totten, Sarah M   +6 more
core   +2 more sources

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source