Results 41 to 50 of about 2,929,035 (154)

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences

BMC Genomics, 2011
Background DNA methylation has been linked to genome regulation and dysregulation in health and disease respectively, and methods for characterizing genomic DNA methylation patterns are rapidly emerging.
De Marzo Angelo M, Zheng Qizhi, Carvalho Benilton, Morgan James D, He Tony L, Badrinath Raghav, Aryee Martin J, Esopi David, Haffner Michael C, Wu Zhijin, Yegnasubramanian Srinivasan, Irizarry Rafael A, Nelson William G   +12 more
doaj   +1 more source

ADAMTS4 mediates LPS‐induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
• ADAMTS4 is induced primarily in cardiac fibroblasts during sepsis. • ADAMTS4 cleaves TSP1 at the 236–246 aa functional region. • TSP1 cleavage activates TGF‐β/Smad and NF‐κB signalling in fibroblasts. • Targeting ADAMTS4 reduces fibroblast activation and cardiac fibrosis.
Zhe‐Wei Zhang, Shi‐Yan Wan, Wen Li, Xiao Lu, Rong Chen, Xin Xing, Wei Lai, Shu‐Yang Sheng, M. M. Mosebetsi, Qing‐Tao Meng, Zi‐Long Lu, Di Fan, Wan‐Li Jiang   +12 more
wiley   +1 more source

SP1 and USF differentially regulate ADAMTS1 gene expression under normoxic and hypoxic conditions in hepatoma cells

, 2016
ADAM metallopeptidase with thrombospondin type I motif, 1 (ADAMTS1) that has both antiangiogenic and aggrecanase activity was dysregulated in many pathophysiologic circumstances.
Turkoglu, Sumeyye Aydogan, Kockar, Feray
core   +1 more source

The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity [PDF]

, 2023
A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS1) is a protease involved in fertilization, cancer, cardiovascular development, and thoracic aneurysms.
Qi, Yawei, Lee, K, Lee, Karen, Qi, Y, Santamaria, S, Santamaria, Salvatore, Ahnström, Josefin, Josefin Ahnström, Minns, AF, Yamamoto, K, Alexander Frederick Minns, Karen Lee, Yawei Qi, Yamamoto, Kazuhiro, Kazuhiro Yamamoto, Salvatore Santamaria, Ahnström, J, Minns, Alexander Frederick   +17 more
core   +1 more source

Hyaluronan (HA) Receptors: Discovery, Function & Pathology

Proteoglycan Research, Volume 4, Issue 3, July 2026.
ABSTRACT Hyaluronan (HA) is typically a long polymer of the repeating disaccharide, glucuronic acid‐β‐(1‐3)‐N‐acetylglucosamine polymerized by β(1‐4) bonds, with no obvious active site for biological activity. However, this dynamic polymer is vital for life in all metazoans and has a diverse array of functional characteristics due to the proteins that ...
Abby E. Bopp, Linda B. Pratt, Callan J. Schroder, Joseph D. Staab, Grant D. Hatcher, Joshua T. McWilliams, Michael C. Wilhelm, Ashley C. Texel, Edward N. Harris   +8 more
wiley   +1 more source

SPARC induction and correlation with inflammation and fibrosis in a mouse model of alkali-induced abdominal adhesions

Journal of Pharmacological Sciences
Postoperative abdominal adhesions can cause several complications, such as intestinal obstruction, female infertility, and chronic pelvic pain. By alkaline cauterization of the cecum, we established a mouse abdominal adhesion model to investigate the ...
Hiroe Toba, Denan Jin, Shinji Takai
doaj   +1 more source

Role of ADAMTS1 and ADAMTS5 in male infertility

, 2016
The aim of this study was to investigate the relationship of infertility with metalloproteinases ADAMTS1 and ADAMTS5, which are known to be responsible for the degradation of extracellular matrix (ECM) proteins associated with many diseases.
Aydos, S. E., Aydos, K., Sunguroglu, A., Demircan, K., Yukselten, Y.   +4 more
core   +1 more source

Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.

PLoS ONE, 2014
BackgroundWe hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in ...
Maria Vistnes, Jan Magnus Aronsen, Ida G Lunde, Ivar Sjaastad, Cathrine R Carlson, Geir Christensen   +5 more
doaj   +1 more source

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System [PDF]

, 2018
Protein folding in the cell requires ATP-driven chaperone machines such as the conserved Hsp70 and Hsp90. It is enigmatic how these machines fold proteins.
Mayer, Matthias, Sub Cellular Protein Chemistry, Kityk, R., Rüdiger, S.G.D., Morán Luengo, T., Cellular Protein Chemistry   +5 more
core   +2 more sources