Results 21 to 30 of about 2,929,035 (154)

Reprogramming of VEGF-mediated extracellular matrix changes through autocrine signaling

Cancer Biology & Therapy, 2023
Vascular endothelial growth factor (VEGF) plays key roles in angiogenesis, vasculogenesis, and wound healing. In cancers, including triple negative breast cancer (TNBC), VEGF has been associated with increased invasion and metastasis, processes that ...
Eibhlin Goggins, Yelena Mironchik, Samata Kakkad, Desmond Jacob, Flonne Wildes, Zaver M. Bhujwalla, Balaji Krishnamachary   +6 more
doaj   +1 more source

Progestin and Nuclear Progestin Receptor Are Essential for Upregulation of Metalloproteinase in Zebrafish Preovulatory Follicles

Frontiers in Endocrinology, 2018
Ovulation requires proteinases to promote the rupture of ovarian follicles. However, the identity of these proteinases remains unclear. In our previous studies using RNA-seq analysis of differential expressed genes, we found significant down-regulation ...
Dong Teng Liu, Dong Teng Liu, Nichole J. Carter, Xin Jun Wu, Wan Shu Hong, Shi Xi Chen, Yong Zhu, Yong Zhu   +7 more
doaj   +1 more source

Cell-Based HIF1α Gene Therapy Reduces Myocardial Scar and Enhances Angiopoietic Proteome, Transcriptomic and miRNA Expression in Experimental Chronic Left Ventricular Dysfunction

Frontiers in Bioengineering and Biotechnology, 2022
Recent preclinical investigations and clinical trials with stem cells mostly studied bone-marrow-derived mononuclear cells (BM-MNCs), which so far failed to meet clinically significant functional study endpoints.
Edit Gara, Edit Gara, Sang-Ging Ong, Johannes Winkler, Katrin Zlabinger, Dominika Lukovic, Bela Merkely, Maximilian Y. Emmert, Maximilian Y. Emmert, Maximilian Y. Emmert, Petra Wolint, Simon P. Hoerstrup, Mariann Gyöngyösi, Joseph C. Wu, Noemi Pavo   +14 more
doaj   +1 more source

Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells

Biochemistry and Biophysics Reports, 2018
Hypoxia, a hallmark characteristic of glioblastoma (GBM) induces changes in the transcriptome and the proteome of tumor cells. We discovered that hypoxic stress produces significant qualitative and quantitative changes in the protein content of secreted ...
Rajshekhar A. Kore, Jacob L. Edmondson, Samir V. Jenkins, Azemat Jamshidi-Parsian, Ruud P.M. Dings, Nathan S. Reyna, Robert J. Griffin   +6 more
doaj   +1 more source

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function. [PDF]

Pharmacol Res Perspect
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
O'Callaghan LA, Powell K, Chess-Williams R, McDermott C.   +3 more
europepmc   +2 more sources

Hypoxia Limits the Growth of Bovine Follicles in Vitro by Inhibiting Estrogen Receptor α

Animals, 2019
Female animals living in the Qinghai-Tibet Plateau have lower ovulation rates because of the hypoxic environment, however, the mechanism of hypoxia on animal follicles is unclear.
Lizhu Ma, Liqiang Wang, Huimin Gao, Ning Liu, Yuxin Zheng, Yan Gao, Shujie Liu, Zhongliang Jiang   +7 more
doaj   +1 more source

The ADAMTS1 protease gene is required for mammary tumor growth and metastasis

, 2011
A disintegrin and metalloprotease with thrombospondin motifs protein 1 (ADAMTS1) is a protease commonly up-regulated in metastatic carcinoma. Its overexpression in cancer cells promotes experimental metastasis, but whether ADAMTS1 is essential for ...
Frewin, K., Izza de Arao Tan, Williams, Elizabeth D., Wendy V. Ingman, Ingman, W., Williams, E., Tan, Izza de Arao, Kate M. Frewin, Tan, I., Russell, Darryl L., Kenneth Opeskin, Frewin, Kate M., Ricciardelli, Carmela, Darryl L. Russell, Pritchard, M., Elizabeth D. Williams, Pritchard, Melanie A., Carmela Ricciardelli, Opeskin, Kenneth, Melanie A. Pritchard, Opeskin, K., Russell, D., Ingman, Wendy V., Ricciardelli, C.   +23 more
core   +1 more source

Erythropoietin-producing hepatocellular A7 triggering ovulation indicates a potential beneficial role for polycystic ovary syndromeResearch in context

EBioMedicine, 2018
Background: The ovulatory dysfunction mechanisms underlying polycystic ovary syndrome (PCOS) are not completely understood. And the roles of EPHA7 and EPHA7-regulated pathway factors in the pathogenesis of anovulation remain to be elucidated. Methods: We
Shang Li, Junyu Zhai, Jiansheng Liu, Fangfang Di, Yun Sun, Weiping Li, Zi-Jiang Chen, Yanzhi Du   +7 more
doaj   +1 more source

CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry, Hendershot, Linda M., Feige, Matthias J., Ineke Braakman, Matthias J. Feige, Braakman, Ineke, Cellular Protein Chemistry, Linda M. Hendershot   +7 more
core   +1 more source

Galnt1 is required for normal heart valve development and cardiac function.

PLoS ONE, 2015
Congenital heart valve defects in humans occur in approximately 2% of live births and are a major source of compromised cardiac function. In this study we demonstrate that normal heart valve development and cardiac function are dependent upon Galnt1, the
E Tian, Sharon R Stevens, Yu Guan, Danielle A Springer, Stasia A Anderson, Matthew F Starost, Vyomesh Patel, Kelly G Ten Hagen, Lawrence A Tabak   +8 more
doaj   +1 more source