Results 1 to 10 of about 3,992 (98)

Activation of G Protein-Coupled Estrogen Receptor Induces p53 and ADAMTS1 to Inhibit Tumor Growth and Suppress Liver Cancer Metastasis [PDF]

Cancers
Background/Objectives: Liver cancer is a common cause of cancer-related deaths among men and women globally. A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMST1) has been associated with various cancers, including prostate, esophageal, renal, and breast cancers. However, its role in liver cancer remains unclear.
Joohee Jung, Jeong Hee Moon, Jung Joohee   +2 more
exaly   +4 more sources

Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1. [PDF]

PLoS ONE, 2012
The chondroitin sulfate-bearing proteoglycans, also known as lecticans, are a major component of the extracellular matrix (ECM) in the central nervous system and regulate neural plasticity.
Matthew D Howell, Antoni X Torres-Collado, M Luisa Iruela-Arispe, Paul E Gottschall   +3 more
doaj   +6 more sources

Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8 [PDF]

Advanced Science
‐Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide, with post‐infarction cardiac remodeling, particularly excessive scar formation, representing a critical determinant of patient outcomes.
Chun‐Yan Kong, Zhen Guo, Yu‐Lan Ma, Ming‐Yu Wang, Hai‐Yang Ni, Pan Wang, Wen‐Jun Qiu, En‐Gui Wang, Zhou Li, Zheng Yang, Bo Shen, Qi‐Zhu Tang   +11 more
doaj   +2 more sources

Vascular Endothelial Growth Factor Upregulates Expression of ADAMTS1 in Endothelial Cells through Protein Kinase C Signaling

Investigative Opthalmology & Visual Science, 2006
ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs) has been demonstrated to inhibit angiogenesis in vivo and to suppress endothelial cell proliferation in vitro. The purpose of this study was to investigate the expression of ADAMTS1 in endothelial cells and in a mouse model of ischemia-induced retinal neovascularization and to ...
Elia Duh
exaly   +3 more sources

Association analysis of single nucleotide polymorphisms in the LIFR gene with lambing number in sheep [PDF]

Frontiers in Veterinary Science
Lambing number trait in sheep is a complex trait controlled by multiple genes, and low lambing number has a severe economic impact on the sheep industry.
Yuliang Wen, Yuping Xiang, Yuping Xiang, Runan Zhang, Kai Liu, Yufang Liu, Mingxing Chu   +6 more
doaj   +2 more sources

Integrating bioinformatics and machine learning to elucidate the role of protein glycosylation-related genes in the pathogenesis of diabetic kidney disease. [PDF]

PLoS ONE
BackgroundDiabetic kidney disease (DKD) is a severe global complication of diabetes, yet its molecular mechanisms remain incompletely understood. This study aimed to investigate the role of protein glycosylation in DKD pathogenesis and its association ...
Ziyang Liu, Zengyuan Qin, Wenxin Bai, Shasha Wang, Chunling Huang, Na Li, Lei Yan, Yue Gu, Fengmin Shao   +8 more
doaj   +2 more sources

Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk

Frontiers in Aging Neuroscience, 2022
Amyloid-β (Aβ) derived from amyloid precursor protein (APP) hydrolysis is acknowledged as the predominant hallmark of Alzheimer’s disease (AD) that especially correlates to genetics and daily activities.
Yunjie Qiu, Longze Sha, Longze Sha, Xiuneng Zhang, Guanjun Li, Wanwan Zhu, Wanwan Zhu, Qi Xu, Qi Xu   +8 more
doaj   +1 more source

Hypochlorous Acid and Chloramines Induce Specific Fragmentation and Cross-Linking of the G1-IGD-G2 Domains of Recombinant Human Aggrecan, and Inhibit ADAMTS1 Activity

Antioxidants, 2023
Atherosclerosis is a chronic inflammatory disease and a leading cause of mortality. It is characterized by arterial wall plaques that contain high levels of cholesterol and other lipids and activated leukocytes covered by a fibrous cap of extracellular ...
Yihe Wang, Astrid Hammer, Gerald Hoefler, Ernst Malle, Clare L. Hawkins, Christine Y. Chuang, Michael J. Davies   +6 more
doaj   +1 more source

ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1

Cell & Bioscience, 2023
Background ISGylation is a post-translational protein modification that regulates many life activities, including immunomodulation, antiviral responses, and embryo implantation.
Yaru Chen, Jiawei Zhou, Shang Wu, Lei Wang, Gaogui Chen, Dake Chen, Xianwen Peng, Yi-Liang Miao, Shuqi Mei, Fenge Li   +9 more
doaj   +1 more source

Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst

BMC Oral Health, 2021
Background ADAMTS expression can be associated with several inflammatory processes, and has been correlated with tumorigenesis of some neoplasms, but its participation in the development of periapical lesions has not been investigated.
Nádia Marielly Gomes Batista, Antonia Taiane Lopes de Moraes, Karolyny Martins Balbinot, Osvaldo Rodrigues de Souza Neto, Juliana Melo da Silva Brandão, Maria Sueli da Silva kataoka, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro   +7 more
doaj   +1 more source