ADAMTS1 Promotes Adhesion to Extracellular Matrix Proteins and Predicts Prognosis in Early Stage Breast Cancer Patients [PDF]
Cellular Physiology and Biochemistry, 2019 Despite, several studies demonstrating pro-metastatic effects of the metalloproteinase ADAMTS1 in breast cancer, its role in facilitating the metastatic cascade remains unclear. To date there have been limited studies that have examined the expression of ADAMTS1 in primary and metastatic breast cancer tissues.We assessed ADAMTS1 mRNA levels in ...
Tan, I.A. +3 more
openaire +5 more sources
PGF2α-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer [PDF]
BMC Cancer, 2010 Background An increase in cancer cell invasion and microvascular density is associated with a poorer prognosis for patients with endometrial cancer. In endometrial adenocarcinoma F-prostanoid (FP) receptor expression is elevated, along with its ligand ...
Keightley Margaret C +2 more
doaj +3 more sources
Proteolytic remodelling of the extracellular matrix by pericytes. [PDF]
FEBS JPericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Burkhard T +4 more
europepmc +2 more sources
Frontiers in Endocrinology, 2022 Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women of reproductive age. Ovarian dysfunction including abnormal steroid hormone synthesis and follicular arrest play a vital role in PCOS pathogenesis.
Baoying Liao +17 more
doaj +1 more source
Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis [PDF]
, 2012 Angiogenesis plays an important role in tumor progression. Several reports have demonstrated that a disintegrin and metalloproteinase with thrombospondin motifs1 (ADAMTS1) inhibited angiogenesis via multiple mechanisms.
Inagaki, Junko +11 more
core +2 more sources
Early Diagnosis of Pancreatic Cancer: The Key for Survival
Diagnostics, 2020 Pancreatic cancer (PC) is one of the most aggressive forms of cancer. Negative prognosis is mainly due to the late diagnosis in advanced stages, when the disease is already therapeutically overcome.
Gina Gheorghe +9 more
doaj +1 more source
Androgen-Independent Prostate Cancer - studies on angiogenesis and ADAMTS1 [PDF]
, 2009 Androgen deprivation therapy (ADT) is the standard treatment for advanced prostate cancer since prostate tumors initially are dependent on androgens for growth.
Gustavsson, Heléne
core +2 more sources
The 3'-untranslated region of ADAMTS1 regulates its mRNA stability [PDF]
, 2009 ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is an inflammatory-induced gene. We have previously reported that ADAMTS1 was strongly but transiently expressed in the infarcted heart. In this study, we investigated whether a 3'
Demircan, Kadir +9 more
core +1 more source
The Long Noncoding RNA MALAT-1 Is Highly Expressed in Ovarian Cancer and Induces Cell Growth and Migration. [PDF]
PLoS ONE, 2016 BACKGROUND:Metastasis associated in lung adenocarcinoma transcript-1 (MALAT-1) is overexpressed during cancer progression and promotes cell migration and invasion in many solid tumors.
Yanqing Zhou +7 more
doaj +1 more source
Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
core +1 more source