Results 121 to 130 of about 5,085,110 (360)
Trained Immunity and its Role in Health and Diseases: A Review [PDF]
Indian Journal of Medical BiochemistryThe term immunity mostly refers to adaptive immunity, even though innate immunity also plays a crucial role. Immunological memory is the key feature distinguishing adaptive immunity from innate immunity.
Santosh Kumar Gupta
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Adaptive immunity or evolutionary adaptation? Transgenerational immune systems at the crossroads
Biology & Philosophy, 2022 AbstractIn recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive immune system. Particularly the discovery of CRISPR-Cas9-based systems has triggered a discussion about how to classify adaptive ...
openaire +3 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Aberrant adaptive immune response underlies genetic susceptibility to tuberculosis
Frontiers in ImmunologyMycobacterium tuberculosis (Mtb) remains a major threat worldwide, although only a fraction of infected individuals develops tuberculosis (TB). TB susceptibility is shaped by multiple genetic factors, and we performed comparative immunological analysis ...
Anastasiia Tsareva +17 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer
, 2013 Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection.
Ferreira, Silvio C +3 more
core +2 more sources
Sensory neurons drive adaptive immunity in contact hypersensitivity [PDF]
, 2021 Knut Schäkel
openalex +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Adaptive immunity is required for durable responses to alectinib in murine models of EML4-ALK lung cancer [PDF]
, 2022 Emily K. Kleczko +14 more
openalex +1 more source