Results 61 to 70 of about 274,536 (135)

Bat adaptive immunity [PDF]

Nature Immunology, 2019
openaire   +2 more sources

The TCR and LCK: foundations for T-cell activation and therapeutic innovation

Frontiers in Immunology
The T cell receptor (TCR)-CD3 complex is crucial to adaptive immunity, driving antigen recognition and intracellular signaling cascades. CD3 subunits harbor key cytoplasmic motifs that recruit signaling proteins like LCK. While distal αβ TCR signaling is
Nadine M. Woessner, Nadine M. Woessner, Valeria Uleri, Valeria Uleri, Ondrej Stepanek, Susana Minguet, Susana Minguet, Susana Minguet   +7 more
doaj   +1 more source

TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases

Nature Communications
The cytokine TNF can trigger highly proinflammatory RIPK1-dependent cell death. Here, we show that the two adapter proteins, TANK and AZI2, suppress TNF-induced cell death by regulating the activation of TBK1 kinase.
Andrea Ujevic, Daniela Knizkova, Alzbeta Synackova, Michaela Pribikova, Tijana Trivic, Anna Dalinskaya, Ales Drobek, Veronika Niederlova, Darina Paprckova, Roldan De Guia, Petr Kasparek, Jan Prochazka, Juraj Labaj, Olha Fedosieieva, Bernhard Florian Roeck, Ondrej Mihola, Zdenek Trachtulec, Radislav Sedlacek, Ondrej Stepanek, Peter Draber   +19 more
doaj   +1 more source

Adaptive Immunity & Vaccination [PDF]

Journal of Investigative Dermatology, 2015
openaire   +2 more sources

Atypical pericapillary Ly6G⁺Nur77⁺ macrophages initiate type-2 immune responses to allergens in the mouse lung

Nature Communications
The mechanisms of airway allergen sensing and type 2 immune response initiation remain poorly understood. Using a mouse house dust mite (HDM)-induced allergic airway model, we identify a population of lung macrophages located close to alveolar ...
Audrey Meloun, Holly Bachus, Crystal Lewis, Brittany Dulek, Shivangi Dave, Dave Durell Hill, Gabriela Pessenda, Jose Carlos Gonzalez, P’ng Loke, Alexander F. Rosenberg, Beatriz León   +10 more
doaj   +1 more source

Adaptive Immunity [PDF]

Journal of Investigative Dermatology, 2014
Javier Chinen, Thomas A. Fleisher, William T. Shearer   +2 more
openaire   +2 more sources

Potential of Vγ9Vδ2T cells in tuberculosis: integration of innate and adaptive immunity for vaccine development. [PDF]

PeerJ
Di D, Gao C, Deng Y, Li Y, Zhang Y.
europepmc   +1 more source

Adaptive Immunity and Alzheimer's Disease: Dual Roles in Neurodegeneration and Neuroprotection with Therapeutic Implications. [PDF]

Biomol Ther (Seoul)
Ahn YM, Shin MK.
europepmc   +1 more source

The Influence of Innate Immunity, Adaptive Immunity and Diet on Intestinal Microbiota Following Trichuris muris Infection [PDF]

Parasite Immunol
Walusimbi B, Hayes K, Lawson M, Thompson S, Bancroft A, Elliott A, Grencis R.   +6 more
europepmc   +2 more sources

Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren’s syndrome is associated with B cell hyperactivity and type I interferon activity

RMD Open, 2020
Timothy R D J Radstake, Joel A G van Roon, Maarten R Hillen, Sofie L M Blokland, Aridaman Pandit, Katia Urso, Emma Koppe, Ana Pinheiro Lopes, Tom Slocombe, André van Maurik   +9 more
doaj   +1 more source