Results 41 to 50 of about 110,599 (252)
Adaptation ofSaccharomyces cerevisiaeto saline stress through laboratory evolution [PDF]
Journal of Evolutionary Biology, 2011 AbstractMost laboratory evolution studies that characterize evolutionary adaptation genomically focus on genetically simple traits that can be altered by one or few mutations. Such traits are important, but they are few compared with complex, polygenic traits influenced by many genes.
Dhar Riddhiman +4 more
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Clinical Insights Into Hypercalcemia of Malignancy in Childhood
Pediatric Blood &Cancer, EarlyView.ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley +1 more source
ALEdb 1.0: A Database of Mutations from Adaptive Laboratory Evolution Experimentation [PDF]
Nucleic Acids Research, 2018 ABSTRACTFull genomic sequences are readily available, but their functional interpretation remains a fundamental challenge. Adaptive Laboratory Evolution (ALE) has emerged as an experimental approach to discover causal mutations that confer desired phenotypic functions. Thus, ALE not only represents a controllable experimental approach to systematically
Patrick V Phaneuf +3 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego +10 more
wiley +1 more source
Food Bioengineering, 2023 Fructilactobacillus (F.) sanfranciscensis LS1 is one of the dominant strains in sourdough. Ethanol produced during fermentation is an inevitable stress factor for this stain.
Yan Liu +5 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Frontiers in Ecology and EvolutionEothenomys miletus is an endemic species that inhabits the Hengduan Mountain regions (HDR) and serves as one of the primary hosts for plague and hantaviruses. While the physiological characteristics of E.
Yanfei Cai +4 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Adaptive laboratory evolution of Escherichia coli under acid stress
Microbiology, 2019 AbstractThe ability ofEscherichia colito tolerate acid stress is important for its survival and colonization in the human digestive tract. Here, we performed adaptive laboratory evolution of the laboratory strainE. coliK-12 MG1655 at pH 5.5 in glucose minimal medium.
Bin Du +12 more
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BMC MicrobiologyIn the face of global warming, the Eothenomys miletus (Red - backed vole), a species dwelling in highland mountainous regions, is likely to encounter difficulties. Given its restricted mobility, it may struggle with the uncertainty of food resources.
Ting Jia +3 more
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