Results 61 to 70 of about 44,966 (284)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation [PDF]

, 2015
The acquisition of endocrine therapy resistance in estrogen receptor a (ERa) breast cancer patients represents a major clinical problem. Notch signalling has been extensively linked to breast cancer especially in patients who fail to respond to endocrine
Aifantis, Apatira, Apweiler, Brennan, Carroll, Chazotte, Chen, Coombes, Darbre, Eikesdal, Forgac, Goloubeva, Gul, Hill, Ho, Joffe, Johnston, Jones, Jones, Jones, Kane, Kang, Kocak, Lake, Le Borgne, Lendahl, Liu, Lupien, Mader, Mao, Martinez, McPherson, Medici, Meyer, Miele, Miele, Miele, Miyamoto, Nguyen, Nicolson, Roegiers, Sarkar, Schiff, Schilling, Schupbach, Sutherland, Taylor, Urbe, Vaccari, Venkanteshan, Wang, Webster, Wieczorek, Wong, Zahler   +54 more
core   +3 more sources

Proton radiography for in vivo range verification in adaptive proton therapy

, 2022
Proton therapy is a novel radiotherapy technique that exploits the characteristic dose deposition of proton beams through matter to deliver a very localized treatment via radiation. With this technology, the desired radiation dose is given to the tumor, and healthy organs surrounding the tumor can be spared more efficiently than with conventional x-ray
openaire   +1 more source

Proton dose calculation on scatter‐corrected CBCT image: Feasibility study for adaptive proton therapy

Medical Physics, 2015
Purpose:To demonstrate the feasibility of proton dose calculation on scatter‐corrected cone‐beam computed tomographic (CBCT) images for the purpose of adaptive proton therapy.Methods:CBCT projection images were acquired from anthropomorphic phantoms and a prostate patient using an on‐board imaging system of an Elekta infinity linear accelerator.
Yang-Kyun, Park, Gregory C, Sharp, Justin, Phillips, Brian A, Winey   +3 more
openaire   +2 more sources

Hypoxia adapted relative biological effectiveness models for proton therapy: a simulation study

Biomedical Physics & Engineering Express, 2022
Abstract In proton therapy, a constant relative biological effectiveness (RBE) factor of 1.1 is applied although the RBE has been shown to depend on factors including the Linear Energy Transfer (LET). The biological effectiveness of radiotherapy has also been shown to depend on the level of oxygenation, quantified by the oxygen ...
Guillermo Garrido-Hernandez, Helge Henjum, Marte Kåstad Høiskar, Tordis Johnsen Dahle, Kathrine Røe Redalen, Kristian Smeland Ytre-Hauge   +5 more
openaire   +4 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Proton Image-guided Radiation Assignment for Therapeutic Escalation via Selection of locally advanced head and neck cancer patients [PIRATES]: A Phase I safety and feasibility trial of MRI-guided adaptive particle radiotherapy

Clinical and Translational Radiation Oncology, 2022
Introduction: Radiation dose-escalation for head and neck cancer (HNC) patients aiming to improve cure rates is challenging due to the increased risk of unacceptable treatment-induced toxicities.
Lisanne V. van Dijk, Steven J. Frank, Ying Yuan, Brandon Gunn, Amy C. Moreno, Abdallah S.R. Mohamed, Kathryn E. Preston, Yun Qing, Michael T. Spiotto, William H. Morrison, Anna Lee, Jack Phan, Adam S. Garden, David I. Rosenthal, Johannes A. Langendijk, Clifton D. Fuller   +15 more
doaj   +1 more source

Three-Dimensional Dose Prediction for Lung IMRT Patients with Deep Neural Networks: Robust Learning from Heterogeneous Beam Configurations

, 2019
The use of neural networks to directly predict three-dimensional dose distributions for automatic planning is becoming popular. However, the existing methods only use patient anatomy as input and assume consistent beam configuration for all patients in ...
Barragan Montero, Ana Maria, Geets, Xavier, Jiang, Steve, Lin, Mu-Han, Lu, Weiguo, Nguyen, Dan, Norouzi-Kandalan, Roya, Sterpin, Edmond   +7 more
core   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

The inflammatory process of gout and its treatment. [PDF]

, 2006
Gouty arthritis is a characteristically intense acute inflammatory reaction that erupts in response to articular deposits of monosodium urate (MSU) crystals.
Cronstein, Bruce N, Terkeltaub, Robert
core   +2 more sources