Results 81 to 90 of about 3,973,865 (282)

Beyond Photons: Emerging Advances and Clinical Potential of Proton Beam Therapy in Gynecological Malignancies

open access: yesRadiation
Radiation therapy is central to the management of gynecological cancers, including endometrial, cervical, ovarian, and vaginal malignancies. Despite advances in photon-based techniques, treatment-related toxicity remains significant owing to the ...
Lifeng Chen, Li Wang, Hamid A. Bakshi
doaj   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera   +20 more
wiley   +1 more source

Innovative radiotherapy approaches

open access: yesESMO Gastrointestinal Oncology
Radiotherapy (RT) with concurrent chemotherapy is the standard of care for squamous-cell carcinoma of the anal canal (SCCAC), achieving favorable results in terms of local control and overall survival. However, locoregional failure remains common despite
G. Chiloiro   +8 more
doaj   +1 more source

Proton Therapy in Uveal Melanoma [PDF]

open access: yes
Background/Objectives: Uveal melanoma is the most common primary intraocular malignancy in adults. Treatment options for localized, early-stage disease include enucleation, brachytherapy, and proton beam therapy.
Choi, J. Isabelle   +11 more
core   +1 more source

Biodegradable and Biocompatible Functional Polymers for Biomedical Applications

open access: yesAdvanced Functional Materials, EarlyView.
Biodegradable and biocompatible functional polymers integrate electrical, mechanical, and stimuli‐responsive functionalities while enabling programmed degradation under physiological conditions. This review introduces recent advances in conductive, shape‐memory, self‐healing, photocurable, and adhesive polymer systems, emphasizing material design ...
Won Bae Han   +5 more
wiley   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

open access: yesAdvanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro   +25 more
wiley   +1 more source

Proton-counting radiography for proton therapy: a proof of principle using CMOS APS technology

open access: yes, 2014
Despite the early recognition of the potential of proton imaging to assist proton therapy (Cormack 1963 J. Appl. Phys. 34 2722), the modality is still removed from clinical practice, with various approaches in development. For proton-counting radiography
Spyros Manolopoulos (17189305)   +9 more
core   +5 more sources

Proton Image-guided Radiation Assignment for Therapeutic Escalation via Selection of locally advanced head and neck cancer patients [PIRATES]: A Phase I safety and feasibility trial of MRI-guided adaptive particle radiotherapy

open access: yesClinical and Translational Radiation Oncology, 2022
Introduction: Radiation dose-escalation for head and neck cancer (HNC) patients aiming to improve cure rates is challenging due to the increased risk of unacceptable treatment-induced toxicities.
Lisanne V. van Dijk   +15 more
doaj   +1 more source

Proton Therapy in the Management of Hepatocellular Carcinoma [PDF]

open access: yes, 2022
SIMPLE SUMMARY: Radiation therapy is among the locoregional therapy modalities used to treat unresectable or medically inoperable hepatocellular carcinoma (HCC).
Hilal, Lara   +11 more
core   +1 more source

Mechanical Programming of PEGDA‐β‐CD Polyrotaxane‐Based Hydrogels via Host–Guest Molecular Recognition

open access: yesAdvanced Functional Materials, EarlyView.
A mechanically programmable hydrogel for tissue engineering is developed by modulating the molecular threading density of poly(ethylene glycol) diacrylate‐β‐cyclodextrin (PEGDA‐β‐CD) polyrotaxane and combining it with β‐CD‐modified gelatin. The polyrotaxane‐guided transition from disordered pores to laminar microstructures enables precise tuning ...
Shiyi Chen   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy