Results 71 to 80 of about 3,973,865 (282)

Spot Weight Adaptation for Moving Target in Spot Scanning Proton Therapy [PDF]

Frontiers in Oncology, 2015
This study describes a real-time spot weight adaptation method in spot-scanning proton therapy for moving target or moving patient, so that the resultant dose distribution closely matches the planned dose distribution.The method proposed in this study adapts the weight (MU) of the delivering pencil beam to that of the target spot; it will actually hit ...
Paul eMorel, Xiaodong eWu, Guillaume eBlin, Guillaume eBlin, Stéphane eVialette, Ryan eFlynn, Daniel eHyer, Dongxu eWang   +7 more
openaire   +4 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A Two-Plane Proton Radiography System Using ATLAS IBL Pixel-Detector Modules

Instruments
Accurate knowledge of a patient’s anatomy during every treatment fraction in proton therapy is an important prerequisite to ensure a correct dose deposition in the target volume.
Hendrik Speiser, Claus Maximillian Bäcker, Johannes Esser, Alina Hild, Marco Iampieri, Ann-Kristin Lüvelsmeyer, Annsofie Tappe, Helen Thews, Kevin Kröninger, Jens Weingarten   +9 more
doaj   +1 more source

Dose mimicking based strategies for online adaptive proton therapy of head and neck cancer

Physics in Medicine and Biology, 2023
Objective. To compare a not adapted (NA) robust planning strategy with three fully automated online adaptive proton therapy (OAPT) workflows based on the same optimization method: dose mimicking (DM).
Elena Lucia Borderias Villarroel, Albin Fredriksson, S. Cvilic, D. Di Perri, E. Longton, J. Pierrard, Xavier Geets, E. Sterpin   +7 more
semanticscholar   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

PAMELA Overview : design goals and principles [PDF]

, 2009
The PAMELA (Particle Accelerator for MEdicaL Applications) project is to design an accelerator for proton and light ion therapy using non-scaling Fixed Field Alternating Gradient (FFAG) accelerators, as part of the CONFORM project, which is also ...
Easton, M.J., Tzenov, S.I., Khan, A., Pasternak, J., McIntosh, P.A., Witte, H., Johnstone, C., Bliss, N., Machida, S., Edgecock, R., Kelliher, D.J., Rogers, C.T., Peach, K. J., Owen, H.L., Fenning, R.J.L., Vojnovic, B., Barlow, Roger, Sheehy, S. L., Aslaninejad, M., Jones, B., Yokoi, T., Tygier, S.C., Beard, C.D., Pozimski, J.K., Seviour, Rebecca, Rochford, J., Cobb, J.H., Smith, S.L.   +27 more
core   +3 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Potential benefits of adaptive intensity‐modulated proton therapy in nasopharyngeal carcinomas

Journal of Applied Clinical Medical Physics, 2020
AbstractPurposeTo investigate potential advantages of adaptive intensity‐modulated proton beam therapy (A‐IMPT) by comparing it to adaptive intensity‐modulated X‐ray therapy (A‐IMXT) for nasopharyngeal carcinomas (NPC).MethodsTen patients with NPC treated with A‐IMXT (step and shoot approach) and concomitant chemotherapy between 2014 and 2016 were ...
Minatogawa, Hideki, Yasuda, Koichi, Dekura, Yasuhiro, Takao, Seishin, Matsuura, Taeko, Yoshimura, Takaaki, Suzuki, Ryusuke, Yokota, Isao, Fujima, Noriyuki, Onimaru, Rikiya, Shimizu, Shinichi, Aoyama, Hidefumi, Shirato, Hiroki   +12 more
openaire   +3 more sources

Patient-specific stopping power calibration for proton therapy planning based on single-detector proton radiography. [PDF]

, 2015
A simple robust optimizer has been developed that can produce patient-specific calibration curves to convert x-ray computed tomography (CT) numbers to relative stopping powers (HU-RSPs) for proton therapy treatment planning.
Sharp, G, Royle, G, Lu, HM, Doolan, PJ, Testa, M, Bentefour, EH   +5 more
core  

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source