Results 41 to 50 of about 84,822 (253)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Adaptive sliding-mode observer for second order discrete-time MIMO nonlinear systems based on recurrent neural-networks [PDF]

, 2019
This manuscript introduces a novel methodology to solve the state estimation of discrete-time multi-input multi-output (MIMO) nonlinear systems with uncertain dynamics.
A Levant, A Levant, A Levant, A Levant, A Moreno, A Oveisi, A Poznyak, A Poznyak, AN Atassi, C Faria, C-S Tseng, C-S Tseng, G Palli, H Ahmed, H Khalil, H Liu, H Sira-Ramirez, I Boiko, I Chairez, I Chairez, I Salgado, J Davila, J Davila, J Resendiz, L Chen, N Sanchez, NE Cotter, PL Priya, R Ortega, R Taormina, S Haykin, S Sastry, S Spurgeon, S Wen, SF Ardabili, SZ Sarpturk, S M R Kazemi, T Gonzlez, V Gholami, X Liu, Y Yan, Y Yildiz   +41 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Model reference adaptive integral sliding mode control for switched delay systems [PDF]

, 2008
Makalenin ilk sayfası kayda eklenmiştir.This paper proposes a strategy of model reference adaptive integral sliding mode variable structure control to solve the tracking problem for a class of uncertain switched systems with time-varying delay.
Dimirovski, Georgi M., Lian, Jie, Zhao, Jun   +2 more
core  

Adaptive sliding mode observers in uncertain chaotic cryptosystems with a relaxed matching condition [PDF]

, 2006
We study the performance of adaptive sliding mode observers in chaotic synchronization and communication in the presence of uncertainties. The proposed robust adaptive observer-based synchronization is used for cryptography based on chaotic masking ...
Raoufi, R., Zinober, A.S.I.
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Adaptive backstepping and sliding mode control of a quadrotor

Journal of the Brazilian Society of Mechanical Sciences and Engineering
Abstract This article proposes a simple robust adaptive control architecture with minimum parameter estimation laws for trajectory tracking of a quadrotor subjected to parametric variations and environmental disturbances. This simple control architecture aims to achieve highly accurate, robust, and fast trajectory tracking of the ...
muhammad maaruf, Muhammad Gulzar, Abdulrazaq Nafiu Abubakar   +2 more
openaire   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Adaptive integral sliding mode control for active vibration absorber design [PDF]

, 2000
A new tuning method for active vibration absorber design is presented in this paper. A robust, adaptive control scheme based on a variable structure with an adaptive discontinuity surface is designed and simulated.
Cao, Tri-Tan Van, Chen, Lei, He, Fangpo, Sammut, Karl   +3 more
core