Results 221 to 230 of about 27,279 (252)

Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays

Advanced Science, EarlyView.
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen, Yuman Li, Chenyu Deng, Leran Li, Zhewen Hu, Boon Chin Heng, Yuting Niu, Shiyu Sun, Min Gao, Xiaopei Chi, Ying He, Mingming Xu, Ying Huang, Xuliang Deng   +13 more
wiley   +1 more source

Kdf1 missense mutation caused enamel defects by disrupting cell adhesion and Hippo-YAP signaling in dental epithelium. [PDF]

Int J Oral Sci
Li P, Zeng R, Xue J, Song Y, Wu J, Zeng B, Lin L, Yu D, Zhao W.   +8 more
europepmc   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

From EGFR PTM network to TKI resistance: spatial subtypes and targeting in lung cancer. [PDF]

Cancer Drug Resist
Lai B, Xu C, Lai S, Zhou M, Kong H, Kong E, Yahaya BH.   +6 more
europepmc   +1 more source

NSP1 of Alongshan virus antagonizes type I interferon responses by promoting STUB1-mediated degradation of RIG-I. [PDF]

Cell Commun Signal
Xu F, Song H, Ming R, Zhu Y, Huang M, Xu J, Wang L, Li X, Yang F, Ji H, Tan G.   +10 more
europepmc   +1 more source

Mitochondrial Antiviral Signaling (MAVS) Protein Modulates the Transition from Acute to Persistent Parainfluenza Virus Infection and Resistance to Complement-Mediated Cell Lysis. [PDF]

Viruses
Aquino JR, Parks GD.
europepmc   +1 more source

<i>Toxoplasma</i> effector <i>Tg</i>WIP hijacks dendritic cell actin and motility via Nck1/Grb2 and the WAVE complex. [PDF]

mBio
Morales P, Kramer DA, de Moraes de Siqueira C, Brown AJ, Sangaré LO, Chen B, Saeij JPJ.   +6 more
europepmc   +1 more source

Development of Antagonist Peptides of the Crk/CrkL SH2 Domains by Modifying the Peripheral Amino Acid Residues of the YXXP Motif. [PDF]

Biochemistry
Park T, Roy A, Douglas JT, Harned L, Neuenswander SA, Large N, Mudduluru G, Broward M, Johnson DK.   +8 more
europepmc   +1 more source

Physalin F Promotes AFG3L2-Mediated Degradation of VISA/MAVS to Suppress Innate Immune Response to RNA Virus. [PDF]

Pathogens
Gao XN, Shu HB, Li M.
europepmc   +1 more source