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Signal-transducing adaptor protein-2 modulates T-cell functions

Exploration of Immunology
Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades. Signal-transducing adaptor protein-2 (STAP-2) contains typical features of adaptor proteins, like a pleckstrin homology (PH)
Tadashi Matsuda, Yuto Sasaki, Kota Kagohashi   +2 more
exaly   +1 more source

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Role of Signal-Transducing Adaptor Protein-1 for T Cell Activation and Pathogenesis of Autoimmune Demyelination and Airway Inflammation

The Journal of Immunology
Abstract Signal-transducing adaptor protein (STAP)-1 is an adaptor protein that is widely expressed in T cells. In this article, we show that STAP-1 upregulates TCR-mediated T cell activation and T cell–mediated airway inflammation. Using STAP-1 knockout mice and STAP-1–overexpressing Jurkat cells, we found that STAP-1 enhanced TCR ...
Kota Kagohashi, Yuto Sasaki, Kiyotaka Ozawa, Takuya Tsuchiya, Shoya Kawahara, Kodai Saitoh, Michiko Ichii, Jun Toda, Yasuyo Harada, Masato Kubo, Yuichi Kitai, Ryuta Muromoto, Kenji Oritani, Jun-ichi Kashiwakura, Tadashi Matsuda   +14 more
openaire   +2 more sources

Signal-Transducing Adaptor Protein 1

2020
openaire   +1 more source

Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells

PLoS ONE, 2020
Jun-Ichi Kashiwakura, Kota Kagohashi, Yuka Morioka   +2 more
exaly  

Cloning of a Novel Signal-Transducing Adaptor Molecule Containing an SH3 Domain and ITAM

Biochemical and Biophysical Research Communications, 1996
Toshikazu Takeshita, Masaya Higuchi, Kenzo Kaneko   +2 more
exaly  

STAM, Signal Transducing Adaptor Molecule, Is Associated with Janus Kinases and Involved in Signaling for Cell Growth and c-myc Induction

Immunity, 1997
Toshikazu Takeshita, Masaya Higuchi, Hironobu Asao   +2 more
exaly  

Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule

Journal of Biological Chemistry, 1997
Hironobu Asao, Nobuyuki Tanaka, Toshikazu Takeshita   +2 more
exaly  

Structural Insight into Modest Binding of a Non-PXXP Ligand to the Signal Transducing Adaptor Molecule-2 Src Homology 3 Domain

Journal of Biological Chemistry, 2003
Tomonori Kaneko, Takashi Kumasaka, Keiji Miyazawa   +2 more
exaly  

Adaptor Protein STAP-2 Modulates Cellular Signaling in Immune Systems

Biological and Pharmaceutical Bulletin, 2014
Yuichi Sekine
exaly  

Rin1 Interacts with Signal-transducing Adaptor Molecule (STAM) and Mediates Epidermal Growth Factor Receptor Trafficking and Degradation

Journal of Biological Chemistry, 2007
Chen Kong, Xiong Su
exaly