Results 231 to 240 of about 27,279 (252)
Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitisopenaire
Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic miceopenaire
Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation [PDF]
Biochemical and Biophysical Research Communications, 2021 Signal-transducing adaptor protein (STAP)-2 is one of the STAP family adaptor proteins and ubiquitously expressed in a variety types of cells. Although STAP-2 is required for modification of Fc epsilon RI signal transduction in mast cells, other ...
Jun-Ichi Kashiwakura +2 more
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Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis
Biological and Pharmaceutical Bulletin, 2021 Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein involved in inflammatory and immune responses, such as inflammatory bowel disease and allergic responses. In this study, we investigated the role of STAP-2 in the pathogenesis of autoimmune hepatitis.
Yuto Sasaki +2 more
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STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses [PDF]
Biological and Pharmaceutical Bulletin, 2021 Signal-transducing adaptor protein (STAP)-2 is an adaptor molecule involved in regulation of several intracellular signaling events in immune cells. STAP-2 contains a pleckstrin homology domain at the N-terminus, an src homology domain in the central ...
Tadashi Matsuda, Kenji Oritani
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Journal of Biological Chemistry, 2012 International audienceAs the upstream component of the ESCRT (endosomal sorting complexes required for transport) machinery, the ESCRT-0 complex is responsible for directing ubiquitinated membrane proteins to the multivesicular body pathway.
CARLOS A Castaneda +2 more
exaly +2 more sources
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European Journal of Immunology, 2014
Signal‐transducing adaptor protein‐2 (STAP‐2) was cloned as a c‐fms/M‐CSF receptor interacting protein. STAP‐2 is an adaptor protein carrying pleckstrin homology and Src homology 2 like domains, as well as a YXXQ motif. STAP‐2 has been indicated to have an ability to bind and modulate a variety of signaling and transcriptional molecules.
Natsuko Fujita +2 more
exaly +3 more sources
Signal‐transducing adaptor protein‐2 (STAP‐2) was cloned as a c‐fms/M‐CSF receptor interacting protein. STAP‐2 is an adaptor protein carrying pleckstrin homology and Src homology 2 like domains, as well as a YXXQ motif. STAP‐2 has been indicated to have an ability to bind and modulate a variety of signaling and transcriptional molecules.
Natsuko Fujita +2 more
exaly +3 more sources
Biological and Pharmaceutical Bulletin, 2008 Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages. In our previous study, we examined the role of STAP-2 in the c-Fms/M-CSF receptor signaling using a murine macrophage tumor cells line, Raw264.7.
Yuichi Sekine +2 more
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Hrs, a Mammalian Master Molecule in Vesicular Transport and Protein Sorting, Suppresses the Degradation of ESCRT Proteins Signal Transducing Adaptor Molecule 1 and 2 [PDF]
Journal of Biological Chemistry, 2005 The degradation and sorting of cytoplasmic and cell-surface proteins are crucial steps in the control of cellular functions. We previously identified three mammalian Vps (vacuolar protein sorting) proteins, Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and signal transducing adaptor molecule (STAM) 1 and -2, which are tyrosine ...
Nobuyuki Tanaka +2 more
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Biochemical and Biophysical Research Communications, 2021
Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT), and is one of the major causes of non-relapse mortality. Transferred mature lymphocytes are thought to be responsible for GVHD based on the findings that mice transplanted with lymphocyte-depleted bone marrow (BM) cells ...
Hideaki Saito +2 more
exaly +3 more sources
Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT), and is one of the major causes of non-relapse mortality. Transferred mature lymphocytes are thought to be responsible for GVHD based on the findings that mice transplanted with lymphocyte-depleted bone marrow (BM) cells ...
Hideaki Saito +2 more
exaly +3 more sources