Results 71 to 80 of about 43,703 (264)

Measuring Tie Strength in Implicit Social Networks [PDF]

, 2011
Given a set of people and a set of events they attend, we address the problem of measuring connectedness or tie strength between each pair of persons given that attendance at mutual events gives an implicit social network between people.
Eliassi-Rad, Tina, Gupte, Mangesh
core   +2 more sources

Granulosa Cell Specific Loss of Adar in Mice Delays Ovulation, Oocyte Maturation and Leads to Infertility

International Journal of Molecular Sciences, 2022
Adenosine deaminases acting on RNA-(ADAR) comprise one family of RNA editing enzymes that specifically catalyze adenosine to inosine (A-to-I) editing. A granulosa cell (GC) specific Adar depleted mouse model [Adar flox/flox:Cyp19a1-Cre/+ (gcAdarKO)] was ...
K. Komrskova, P. Postlerová, M. Frolikova, Rikki N. Nelson, V. Chakravarthi, Anamika Ratri, X. Hong, J. Gossen, L. Christenson   +8 more
semanticscholar   +1 more source

ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression

Cell Reports, 2013
Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells.
Isabel X. Wang, Elizabeth So, James L. Devlin, Yue Zhao, Ming Wu, Vivian G. Cheung   +5 more
doaj   +1 more source

Prediction of scientific collaborations through multiplex interaction networks [PDF]

, 2020
Link prediction algorithms can help to understand the structure and dynamics of scientific collaborations and the evolution of Science. However, available algorithms based on similarity between nodes of collaboration networks are bounded by the limited ...
Aleta, Alberto, Moreno, Yamir, Paolotti, Daniela, Starnini, Michele, Tuninetti, Marta   +4 more
core   +4 more sources

Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene

Epigenetics
Although A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by ‘epigenetically’ regulating proteomic diversity in a temporospatial manner, avoiding the ...
Caiqing Zheng, Ling Ma, Fan Song, Li Tian, Wanzhi Cai, Hu Li, Y. Duan   +6 more
semanticscholar   +1 more source

Monitoring Challenges and Approaches for P2P File-Sharing Systems [PDF]

, 2006
Since the release of Napster in 1999, P2P file-sharing has enjoyed a dramatic rise in popularity. A 2000 study by Plonka on the University of Wisconsin campus network found that file-sharing accounted for a comparable volume of traffic to HTTP, while a ...
Hughes, D., Lee, K., Walkerdine, J.
core   +2 more sources

Rational design of base, sugar and backbone modifications improves ADAR-mediated RNA editing

Nucleic Acids Research
AIMers are short, chemically modified oligonucleotides that induce A-to-I RNA editing through interaction with endogenous adenosine deaminases acting on RNA (ADAR) enzymes.
G. Lu, C. Shivalila, P. Monian, Hui Yu, Ian Harding, Stearne Briem, M. Byrne, Alyse Faraone, Stephen Friend, Olivia Huth, Naoki Iwamoto, T. Kawamoto, Jayakanthan Kumarasamy, A. Lamattina, K. Longo, Leah McCarthy, Andrew McGlynn, Allison Molski, Qianli Pan, Tom Pu, Erin Purcell-Estabrook, Jeff Rossi, S. Standley, Carina Thomas, Alexandra Walen, Hailin Yang, P. Kandasamy, C. Vargeese   +27 more
semanticscholar   +1 more source

Origins and evolution of ADAR‐mediated RNA editing [PDF]

IUBMB Life, 2009
AbstractAdenosine deaminases acting on RNA (ADARs) convert adenosines to inosines in double‐stranded RNA in animals. Identification of more ADAR targets and genome sequences of diverse eukaryotes present an opportunity to elucidate the origin and evolution of ADAR‐mediated RNA editing.
Wenjing Zhang, Yongfeng Jin, Qi Li
openaire   +3 more sources

Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families

Frontiers in Bioscience-Landmark
RNA editing is a crucial post-transcriptional modification that alters the transcriptome and proteome and affects many cellular processes, including splicing, microRNA specificity, stability of RNA molecules, and protein structure.
Alexander Modestov, Anton Buzdin, Maria Suntsova   +2 more
doaj   +1 more source

ADARs: Viruses and Innate Immunity [PDF]

, 2011
Double-stranded RNA (dsRNA) functions both as a substrate of ADARs and also as a molecular trigger of innate immune responses. ADARs, adenosine deaminases that act on RNA, catalyze the deamination of adenosine (A) to produce inosine (I) in dsRNA. ADARs thereby can destablize RNA structures, because the generated I:U mismatch pairs are less stable than ...
openaire   +3 more sources