Results 71 to 80 of about 40,794 (233)

ADAR mediates differential expression of polycistronic microRNAs [PDF]

Nucleic Acids Research, 2014
Adenosine deaminases acting on RNAs (ADARs) convert adenosine residues to inosines in primary microRNA (pri-miRNA) transcripts to alter the structural conformation of these precursors and the subsequent functions of the encoded microRNAs (miRNAs). Here we show that RNA editing by Drosophila ADAR modulates the expression of three co-transcribed miRNAs ...
Geetanjali Chawla, Nicholas S. Sokol
openaire   +3 more sources

Improved arrayed-waveguide-grating layout avoiding systematic phase errors [PDF]

, 2011
We present a detailed description of an improved arrayed-waveguide-grating (AWG) layout for both, low and high diffraction orders. The novel layout presents identical bends across the entire array; in this way systematic phase errors arising from ...
Driessen, Alfred, Ismail, N., Pollnau, Markus, Ridder, René M. de, Sengo, Gabriël, Sun, Fei, Wörhoff, Kerstin   +6 more
core   +4 more sources

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing

Cell Reports, 2020
Summary: Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites are known, few trans regulators have been identified.
Emily C. Freund, Anne L. Sapiro, Qin Li, Sandra Linder, James J. Moresco, John R. Yates, III, Jin Billy Li   +6 more
doaj   +1 more source

Programming ADAR-recruiting hairpin RNA sensor to detect endogenous molecules. [PDF]

Nucleic Acids Res
Qin PP, Chen PR, Tan L, Chu X, Ye BC, Yin BC.   +5 more
europepmc   +2 more sources

Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]

, 2016
Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core   +1 more source

Using participatory scenario planning to explore the synergies and trade‐offs from upland treescape expansion

People and Nature, EarlyView.
Abstract The future of land use in the UK uplands is highly debated, with growing interest in increasing tree cover and other land use changes, alongside a desire to maintain traditional land use patterns and practices. Treescape expansion is likely to result in synergies and trade‐offs between different outcomes, so integrating stakeholder preferences
Melissa Minter, Susan Baker, Euan Bowditch, Sheena Carlisle, Natasha Constant, Alix Syder, Tom Finch   +6 more
wiley   +1 more source

Utilizing AAV-mediated LEAPER 2.0 for programmable RNA editing in non-human primates and nonsense mutation correction in humanized Hurler syndrome mice

Genome Biology, 2023
Background The endogenous adenosine deaminases acting on RNA (ADAR) have been harnessed to facilitate precise adenosine-to-inosine editing on RNAs.
Zongyi Yi, Yanxia Zhao, Zexuan Yi, Yongjian Zhang, Gangbin Tang, Xiaoxue Zhang, Huixian Tang, Wei Zhang, Ying Zhao, Huayuan Xu, Yuyang Nie, Xueqing Sun, Lijun Xing, Lian Dai, Pengfei Yuan, Wensheng Wei   +15 more
doaj   +1 more source

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. [PDF]

, 2019
We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the
Chen, Genghao, Ganesh, Ashwin, Katrekar, Dhruva, Mali, Prashant, Meluzzi, Dario, Shih, Yu-Ru, Varghese, Shyni, Worlikar, Atharv   +7 more
core   +1 more source

Parental Attachment and Academic Well‐Being in Adolescence: Mediation Effect of Perceived Social Support

Psychology in the Schools, EarlyView.
ABSTRACT This cross‐sectional study aimed to explore the mediation mechanism through which the quality of attachment to the parent influences academic well‐being, focusing on the role of multiple sources of perceived social support in a sample of 518 French students (Grades 10–12, 69.7% females, mean age 16 years).
Aline M.‐C. Vansoeterstede, Emilie J. Cappe, Nicolas Meylan, Emilie C. Boujut   +3 more
wiley   +1 more source

Origins and evolution of ADAR‐mediated RNA editing [PDF]

IUBMB Life, 2009
AbstractAdenosine deaminases acting on RNA (ADARs) convert adenosines to inosines in double‐stranded RNA in animals. Identification of more ADAR targets and genome sequences of diverse eukaryotes present an opportunity to elucidate the origin and evolution of ADAR‐mediated RNA editing.
Wenjing Zhang, Yongfeng Jin, Qi Li
openaire   +3 more sources