Results 141 to 150 of about 4,973 (174)

ADAR1 mutation causes ZBP1-dependent immunopathology

Nature, 2022
The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by disrupting the duplex structure of endogenous double-stranded RNA species1,2. A point mutation in the sequence encoding the Z-DNA-binding domain (ZBD) of ADAR1 is associated with ...
Nicholas W. Hubbard, Joshua M. Ames, Megan Maurano, Lan H. Chu, Kim Y. Somfleth, Nandan S. Gokhale, Margo Werner, Jessica M. Snyder, Katrina Lichauco, Ram Savan, Daniel B. Stetson, Andrew Oberst   +11 more
openaire   +2 more sources

RNA Editing, ADAR1, and the Innate Immune Response [PDF]

Genes, 2017
RNA editing, particularly A-to-I RNA editing, has been shown to play an essential role in mammalian embryonic development and tissue homeostasis, and is implicated in the pathogenesis of many diseases including skin pigmentation disorder, autoimmune and inflammatory tissue injury, neuron degeneration, and various malignancies.
Xiaoni Li, Qingde Wang, Timothy Billiar
exaly   +4 more sources

ADAR1 Is Essential For Erythroid Development

Blood, 2013
Abstract Understanding the mechanisms controlling erythroid differentiation may allow therapeutic regulation of erythropoiesis. Focus so far has concentrated on the roles of transcription factors in determining erythroid fate, however one mechanism of gene regulation that has been poorly explored is that of direct modification of RNA. It
Brian Liddicoat, Jochen Hartner, Alistair Chalk, Jun Lu, Stuart H. Orkin, Carl R Walkley   +5 more
openaire   +1 more source

Characterization of ADAR1-mediated modulation of gene expression

Biochemical and Biophysical Research Communications, 2008
Conversion of adenosine into inosine in RNA molecules constitutes an important post-transcriptional mechanism for generating transcript diversity and is catalyzed by adenosine deaminases acting on RNA (ADARs). Intriguingly, we observed that the editing enzyme ADAR1 enhances reporter gene expression in a cellular, plasmid-based system.
Willemijn M, Gommans, Stefan, Maas
openaire   +2 more sources

In search of critical dsRNA targets of ADAR1

Trends in Genetics
Recent studies have underscored the pivotal role of adenosine-to-inosine RNA editing, catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, the specific ADAR1 editing targets crucial for this regulatory function remain elusive.
Erez Y. Levanon, Roni Cohen-Fultheim, Eli Eisenberg   +2 more
openaire   +2 more sources

ADAR1 is essential for intestinal homeostasis and stem cell maintenance [PDF]

Cell Death and Disease, 2013
Adenosine deaminase acting on RNA 1 (ADAR1) is a double-stranded RNA-editing enzyme that converts adenosine (A) to inosine (I), and essential for normal development. In this study, we reported an essential role of ADAR1 in the survival and maintenance of intestinal stem cells and intestinal homoeostasis by suppressing endoplasmic reticulum (ER) stress ...
Jian Yu, Lin Zhang
exaly   +3 more sources

SINEs of cancer therapy success without ADAR1

Nature Reviews Molecular Cell Biology, 2020
RNA editing by ADAR1 destabilizes epigenetic-treatment-induced retrotransposon stem–loops and thus dampens the immune response to the treatment, suggesting that ADAR1 could be a therapeutic target in combination with epigenetic therapy.
openaire   +2 more sources

Loss of ADAR1 induces ferroptosis of breast cancer cells

Cellular Signalling
Adenosine deaminases acting on RNA 1(ADAR1), an RNA editing enzyme that converts adenosine to inosine by deamination in double-stranded RNAs, plays an important role in occurrence and progression of various types of cancer. Ferroptosis has emerged as a hot topic of cancer research in recent years.
Meng-Meng Zhang
exaly   +3 more sources

Regulation of ADAR1 expression

2005
Ét gen kan kode for flere beslægtede proteiner, og reguleringen af dette sker bl.a. på RNA niveau. De livsnødvendige ADAR enzymer kan ændre på et RNA’s egenskaber ved en proces, der kaldes editering. Aktiviteten af en række receptorer i centralnervesystemet kontrolleres af ADAR enzymerne vha. nøje regulerede processer.
openaire   +1 more source

Targeting ADAR1 with a small molecule for the treatment of prostate cancer

Nature Cancer
Despite the initial response to androgen signaling therapy, most cases of prostate cancer (PCa) eventually relapse and remain incurable. The specific function of ADAR1 that governs PCa progression and specific inhibitors of ADAR are underexplored. In this study, we demonstrate that highly expressed ADAR1 is a crucial oncogenic target in PCa and develop
Xiao Wang, Jiaxing Li, Yasheng Zhu, Hongtao Shen, Jiayu Ding, Ting Zeng, Wenjian Min, Shun-Qing Liang, Lei Huang, Zhongrui Shi, Hao Shen, Fei Huang, Kai Yuan, Wenbin Kuang, Minghui Ji, Chengliang Sun, Yi Hou, Liping Wang, Weijiao Chen, Yuzhang Jiang, Haiping Hao, Yibei Xiao, Peng Yang   +22 more
openaire   +2 more sources