Results 121 to 130 of about 8,092 (217)

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

eLife, 2017
ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe neurodevelopmental and inflammatory disease of children, Aicardi-Goutiéres syndrome.
Yize Li, Shuvojit Banerjee, Stephen A Goldstein, Beihua Dong, Christina Gaughan, Sneha Rath, Jesse Donovan, Alexei Korennykh, Robert H Silverman, Susan R Weiss   +9 more
doaj   +1 more source

REPAIR - new tool for RNA editing with Cas13 [PDF]

, 2018
Istraživači su nedavno razvili alat REPAIR koji se sastoji od spojene katalitičke domene deaminaze ADAR i katalitički mrtvog Cas13b, iz obitelji proteina Cas13.
Majsec, Petra
core   +2 more sources

ADAR1 affects HCV infection by modulating innate immune response

Antiviral Research, 2018
The hepatitis C virus (HCV) is a globally prevalent infectious pathogen. As many as 80% of people infected with HCV do not control the virus and develop a chronic infection. Response to interferon (IFN) therapy is widely variable in chronic HCV infected patients, suggesting that HCV has evolved mechanisms to suppress and evade innate immunity ...
Maria Pujantell, Sandra Franco, Iván Galván-Femenía, Roger Badia, Marc Castellví, Edurne Garcia-Vidal, Bonaventura Clotet, Rafael de Cid, Cristina Tural, Miguel A. Martínez, Eva Riveira-Muñoz, José A. Esté, Ester Ballana   +12 more
openaire   +3 more sources

ADAR1 may be involved in the proliferation of acute myeloid leukemia cells via regulation of the Wnt pathway

Cancer Management and Research, 2019
Han Xiao, Qian Cheng, Xinyu Wu, Yishu Tang, Jing Liu, Xin Li Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Xin Li; Jing LiuDepartment of Hematology, The ...
Xiao H, Cheng Q, Wu X, Tang Y, Liu J, Li X   +5 more
doaj  

ADAR1 Promotes Myogenic Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells

Cells
As one of the most important economic traits for domestic animal husbandry, skeletal muscle is regulated by an intricate molecular network. Adenosine deaminase acting on RNA (ADAR1) involves various physiological processes and diseases, such as innate ...
Zihao Zhao, Miao Xiao, Xiaoli Xu, Meijun Song, Dinghui Dai, Siyuan Zhan, Jiaxue Cao, Jiazhong Guo, Tao Zhong, Linjie Wang, Li Li, Hongping Zhang   +11 more
doaj   +1 more source

ADAR1, a promising “protecting” biomarker in oral squamous cell carcinoma [PDF]

, 2019
Campisi, Giuseppina, CAPONIO, VITO CARLO ALBERTO, Dioguardi, Mario, Lo Muzio, Lorenzo, Mascitti, Marco, Santarelli, Andrea   +5 more
core   +1 more source

High-speed atomic force microscopy and 3D modeling reveal the structural dynamics of ADAR1 complexes

Nature Communications
Targeting abnormal dysregulation of adenosine-to-inosine deamination by ADAR enzymes offers a promising therapeutic strategy in cancer research. However, the development of effective inhibitors is impeded by the incomplete structural information on ADAR1
Madhu Biyani, Yasuhiro Isogai, Kirti Sharma, Shoei Maeda, Hinako Akashi, Yui Sugai, Masataka Nakano, Noriyuki Kodera, Manish Biyani, Miki Nakajima   +9 more
doaj   +1 more source

ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2α-mediated translational arrest and is required for efficient viral replication.

PLoS Pathogens
Adenosine deaminase acting on dsRNA 1 (ADAR1) catalyzes the deamination of adenosines to inosines in double-stranded RNAs (dsRNA) and regulates innate immunity by preventing the hyperactivation of cytosolic dsRNA sensors such as MDA5, PKR or ZBP1.
Adwait Parchure, Mia Cesarec, Antonija Braut, Robert Kolman, Vlatka Ivanišević, Marina Čunko, Slađana Bursać, Richard de Reuver, Antonija J Begonja, Umberto Rosani, Siniša Volarević, Jonathan Maelfait, Igor Jurak   +12 more
doaj   +1 more source

The role of RNA editing in cancer development and metabolic disorders [PDF]

, 2018
Kung, Che-Pei, Maggi, Leonard B, Jr., Weber, Jason D   +2 more
core   +2 more sources

The gulf between behavioural psychology and fundamental physiology: a systematic attempt to bridge the gap [PDF]

, 2007
Direct experimentation in much of this area is very difficult or impossible. For such circumstances, it is argued that much can be achieved by a rigorous quantitative programme of interdisciplinary theorizing based on available data.
Traill, RR
core