Results 111 to 120 of about 8,092 (217)

ADAR1 Function Regulates Innate Immune Activation and Susceptibility to Viral Infections

Proceedings, 2020
Viral infection induces innate intracellular antiviral defenses, aimed at restricting virus replication and spread. Therefore, understanding the role and function of innate immune modulators can help to establish novel strategies for viral control. Here,
Maria Pujantell, Eva Riveira-Muñoz, Edurne García-Vidal, Lucía Gutiérrez-Chamorro, Roger Badia, Bonaventura Clotet, Ester Ballana   +6 more
doaj   +1 more source

Assessment of Type I Interferon Signaling in Pediatric Inflammatory Disease [PDF]

, 2017
International audiencePURPOSE: Increased type I interferon is considered relevant to the pathology of a number of monogenic and complex disorders spanning pediatric rheumatology, neurology, and dermatology.
A Brehm, AL Mathieu, Alexandre Belot, Anthony Oojageer, Brigitte Bader-Meunier, CD Conrad, Christine Bodemer, D Tonduti, DM Santer, E Lausch, EC Baechler, EC Baechler, F Allantaz, F Goutieres, GI Rice, GI Rice, GI Rice, GI Rice, Gillian I. Rice, Isabelle Melki, J Hua, JH Livingston, L Bennett, M Berger Rentsch, M Henneke, MA Jang, Marie-Louise Frémond, Mathieu P. Rodero, ME Meuwissen, MP Rodero, Naoki Kitabayashi, P Lebon, P Navon Elkan, P Quartier, P Starokadomskyy, Pierre Quartier, PK Chakraborty, Q Zhou, R Banchereau, S Oon, SA Greenberg, SC Eckard, SM Al-Mayouf, TA Briggs, TB Niewold, Tracy A. Briggs, V Sisirak, X Zhang, Y Li, Y Liu, Yanick J. Crow, YJ Crow, YJ Crow, YJ Crow, YJ Crow, YJ Seo   +55 more
core   +4 more sources

ADAR1: Beyond Just an RNA Editor

Annual Review of Cell and Developmental Biology
The RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) has recently emerged from relative obscurity to be recognized as a key player in a variety of inflammatory diseases, including cancer. This growing recognition has generated interest in developing ADAR1 inhibitors; however, several fundamental questions about the enzyme need to be ...
Martin Marônek, Valentina Lacovich, Anna Cherian, Damiano Amoruso, Pavla Linhartova, Qiupei Du, Janka Melicherová, Liam P. Keegan, Mary A. O'Connell   +8 more
openaire   +1 more source

Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms [PDF]

, 2011
Understanding the genesis of the block haplotype structure of the genome is a major challenge. With the completion of the sequencing of the Human Genome and the initiation of the HapMap project the concept that the chromosomes of the mammalian genome are
Carnegie, P., Dawkins, R.L., Lester, S., Lindley, R.A., Millman, J.A., Pain, G.N., Steele, E.J., Stewart, B.J., Williamson, J.F.   +8 more
core   +2 more sources

An RNA editing fingerprint of cancer stem cell reprogramming [PDF]

, 2015
BackgroundDeregulation of RNA editing by adenosine deaminases acting on dsRNA (ADARs) has been implicated in the progression of diverse human cancers including hematopoietic malignancies such as chronic myeloid leukemia (CML).
Angela C Court, Catriona Jamieson, Christian L Barrett, Elisa Lazzari, Kelly A Frazer, Leslie A Crews, Maria A Zipeto, Qingfei Jiang, Shawn Ali   +8 more
core   +1 more source

Active Ebola Virus Replication and Heterogeneous Evolutionary Rates in EVD Survivors [PDF]

, 2018
Summary: Following cessation of continuous Ebola virus (EBOV) transmission within Western Africa, sporadic EBOV disease (EVD) cases continued to re-emerge beyond the viral incubation period.
Alfson, Arias, Baczko, Barnes, Bass, Bausch, Blackley, Calain, Cattaneo, Christie, Deen, Dejucq, Delwart, Diallo, Dudas, Duffy, George, Gire, Gupta, Gélinas, Iizasa, Jacobs, Kumar, Kuming, Ladner, Li, Martini, Martínez, Mate, Meyer, Meyer, Ni, Park, Pfaller, Pillai, Randall, Rice, Rodriguez, Rowe, Shabman, Simon-Loriere, Sissoko, Sissoko, Smits, Soka, Spengler, Suspène, Tapia, Tong, Uyeki, Varkey, Volchkova, Zahn   +52 more
core   +2 more sources

Overexpression of Egr1 Transcription Regulator Contributes to Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1 Knockout Mice

Cells
Adenosine deaminase acting on RNA 1 (ADAR1) is the principal enzyme for the adenosine-to-inosine RNA editing that prevents the aberrant activation of cytosolic nucleic acid sensors by endogenous double stranded RNAs and the activation of interferon ...
Lisa Zerad, Nadjet Gacem, Fanny Gayda, Lucie Day, Ketty Sinigaglia, Laurence Richard, Melanie Parisot, Nicolas Cagnard, Stephane Mathis, Christine Bole-Feysot, Mary A. O’Connell, Veronique Pingault, Emilie Dambroise, Liam P. Keegan, Jean Michel Vallat, Nadege Bondurand   +15 more
doaj   +1 more source

RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs [PDF]

, 2009
The rugged nature of the RNA structural free energy landscape allows cellular RNAs to respond to environmental conditions or fluctuating levels of effector molecules by undergoing dynamic conformational changes that switch on or off activities such as ...
Gehrke, Lee, Simon, Anne E.
core   +1 more source

Meme kanserli hastalarda ADAR1 gen ifade değişikliklerinin adar1 aracılı RNA düzenlenmesi ile BRCA1 ifadesine etkisi

, 2023
Somatik mutasyonlar ve bağışıklık yanıtından kaçış, kanserin başlamasında ve ilerlemesinde rol oynayan iki temel faktördür. Artan sayıda ikinci nesil dizileme verileriyle birlikte, RNA mutasyonları olarak da adlandırılan transkriptomik modifikasyonlar, normal hücrelerin kötü huylu tümöre geçişini yönlendiren ve aynı zamanda bağışıklık yanıtından kaçmak
openaire   +1 more source

An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

Cell Reports
Summary: Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven interferon induction, and Adar Mavs double mutants, in which interferon induction is prevented, die soon after birth.
Ketty Sinigaglia, Anna Cherian, Qiupei Du, Valentina Lacovich, Dragana Vukić, Janka Melicherová, Pavla Linhartova, Lisa Zerad, Stanislav Stejskal, Radek Malik, Jan Prochazka, Nadège Bondurand, Radislav Sedláček, Mary A. O’Connell, Liam P. Keegan   +14 more
doaj   +1 more source