Results 101 to 110 of about 8,092 (217)

ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer

Tumor Biology, 2017
Tumours with a high mutation burden exhibit considerable neoantigens and tumour-infiltrating lymphocytes. RNA editing by ADAR1 is a source of changes in epitope.
In Hye Song, Young-Ae Kim, Sun-Hee Heo, In Ah Park, Miseon Lee, Won Seon Bang, Hye Seon Park, Gyungyub Gong, Hee Jin Lee   +8 more
doaj   +1 more source

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. [PDF]

, 2015
Aicardi-Goutières syndrome (AGS) is a severe childhood inflammatory disorder that shows clinical and genetic overlap with systemic lupus erythematosus (SLE).
Chédin, Frédéric, Hartono, Stella R, Lim, Yoong Wearn, Sanz, Lionel A, Xu, Xiaoqin   +4 more
core   +2 more sources

Gut metabolites identified in cerebrospinal fluid of genetic interferonopathy support gut–brain endothelial dysfunction

Clinical &Translational Immunology, Volume 15, Issue 2, 2026.
Abstract Objective Aicardi–Goutières syndrome (AGS) is a rare genetic interferonopathy because of aberrant DNA or RNA metabolism with secondary host anti‐viral (interferon) activation. This metabolomics study aimed to improve the biological understanding of AGS and explore potential biomarkers.
Russell C Dale, Madysen Elbourne, Markus J Hofer, Shrujna Patel, Shekeeb Mohammad, Velda X Han, Josephine Yu, Shanlin Fu, Arlene D'Silva, Michelle A Farrar, Sushil Bandodkar, Jingya J Yan   +11 more
wiley   +1 more source

Widespread interaction between ADAR1 and transcriptional byproducts [PDF]

, 2019
AbstractBackgroundADAR1, an adenosine-to-inosine (A-to-I) RNA editing enzyme, has an emerging role in cancer immunotherapy. ADAR1 presumably works by suppressing cellular innate immunity response to endogenously generated double-stranded RNAs through RNA editing.
Wu, Chan-Shuo, Tang, Sze Jing, Tan, Hong Kee, Hung, Li-Yuan, Teo, Wei Wen, Li, Jia, An, Omer, Tan, Kar Tong, Zhou, Qiling, Chen, Leilei, Tenen, Daniel G., Yang, Henry   +11 more
openaire   +1 more source

Effect of interferons on expression of adenosine deaminase acting on RNA 1 and hepatitis B virus replication in human hepatocellular carcinoma cells in vitro

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of type Ⅰ interferons (IFN-α and IFN-β) and type Ⅱ interferon (IFN-γ) on the expression of adenosine deaminase acting on RNA 1 (ADAR1, P110 and P150) and hepatitis B virus (HBV) replication in hepatocellular carcinoma (
LI Yimin, LI Yimin, YUAN Lin, YUAN Lin, YANG Shengyong   +4 more
doaj   +1 more source

Differential Enzymatic Activity of Rat ADAR2 Splicing Variants Is Due to Altered Capability to Interact with RNA in the Deaminase Domain [PDF]

, 2018
In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process.
Barbon, Alessandro, Bonini, Daniela, Colombi, Marina, Filippini, Alice, Gangemi, Fabrizio, Giacopuzzi, Edoardo, La Via, Luca   +6 more
core   +2 more sources

EIF4A3‐Induced Circular RNA circSnd1 Promotes Muscle Atrophy and Muscle Ageing by Stabilizing EEF1A1

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Muscle atrophy is a common complication of ageing, and many chronic conditions, lacks defined therapeutic interventions. It is still mostly unknown how circular RNAs contribute to muscle atrophy. Methods circRNA sequencing and quantitative real‐time PCR were performed to detect the changed circRNAs in muscle atrophy models and aged ...
Jin Li, Bing Jin, Yuwei Yan, Yuying Chen, Xiaohang Yin, Xinyi Ren, Qian Li, Jingying Chen, Siqi Wang, Tingting Yang, Yanan Zhang, Qiumeng Nie, Dongchao Lu, Ming Wu, Yan Yu, Lei Chen, Tarun Keswani, Guoping Li, Dragos Cretoiu, T. Scott Bowen, Junjie Xiao, Yongjun Zheng   +21 more
wiley   +1 more source

Single molecule pull down of double strand RNA binding proteins [PDF]

, 2015
RNA molecules are transcribed as single stranded naturally, but with most of them forming in to structures composed of duplex regions, loop, bulge or mismatches. RNAs with double stranded regions, or known as double-strand RNAs (dsRNAs).
Wang, Xinlei
core  

Zalpha-domains: At the intersection between RNA editing and innate immunity [PDF]

, 2012
The involvement of A to I RNA editing in antiviral responses was first indicated by the observation of genomic hyper-mutation for several RNA viruses in the course of persistent infections.
Athanasiadis, Alekos
core   +1 more source

Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response

MedComm, Volume 7, Issue 2, February 2026.
Increased miR‐3163 targets NUDT21, reducing CPSF5 levels and driving APA dysregulation. This results in 3′UTR shortening of CBFB, which stabilizes RUNX1 and promotes smooth muscle proliferation. PTGER3, is also shortened amplifying hypoxia‐induced RVSP. Together, these pathways contribute to vascular remodeling in PH. Image Created in https://BioRender.
Scott D. Collum, Lisha Zhu, Tingting W. Mills, Rene Girard, Jamie Tran, Tinne C. J. Mertens, Cory Wilson, Nancy Wareing, Erik E. Suarez, Howard J. Huang, Rahat Hussain, Bindu Akkanti, Wenjin J. Zheng, Hari K. Yalamanchili, Bela Patel, Eric J. Wagner, Sandeep Agarwal, Harry Karmouty‐Quintana   +17 more
wiley   +1 more source