Results 131 to 140 of about 4,973 (174)

Structural and mechanistic basis of ADAR1-mediated RNA editing and immune regulation. [PDF]

Cell Insight
Deng X, Elsharkawy M, Gao Y.
europepmc   +1 more source

Exogenous Epstein-Barr virus nuclear antigen 1 induces ADAR1-driven tumor resistance against immunotherapy. [PDF]

Signal Transduct Target Ther
Liu C, Sun Z, Li C, Zhou Y, Gao X, Zhong Y, Luo X, Wang C, Zhang Y, Ni C, Peng M, Jian W, Yang Y, Zhang X, Ren Y, Gong X, Zhao M, Guo X, Cheng C, Chen J, Li X.   +20 more
europepmc   +1 more source

Cancer is an RNA disease: DNA is not destiny, RNA determines leukemia fate. [PDF]

Leukemia
van der Werf I, Jamieson CHM.
europepmc   +1 more source

Two codes of RNA editing by deamination in human diseases. [PDF]

Exp Mol Med
Min DJ, Lee S, Lee YS, Cho J.
europepmc   +1 more source

Role of ADAR1 in Sepsis and Research Progress

Advances in Clinical Medicine
openaire   +1 more source

Inositol hexakisphosphate Functions as a Cofactor and Modulator of ADAR1 Activity

Venegas-Solis F, Lu M, Cohen-Fultheim R, Bender F, Fedeli V, Masunaga T, Fujita M, Zillinger T, Schneider S, Kaufmann A, Saiardi A, Levanon EY, Jessen H, Bauer S.   +13 more
europepmc   +1 more source

Investigating the impact of ADAR1 on HCV replication

Kubů, Martin, Roučová, Kristina, Pospíšek, Martin, Vopálenský, Václav   +3 more
openaire   +1 more source

ADAR1: from basic mechanisms to inhibitors

Trends in Cell Biology
Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in humans and mice results in profound inflammatory diseases characterised by the spontaneous induction of innate immunity.
Parinaz Mehdipour, Jan Rehwinkel
exaly   +3 more sources

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ADAR1 edits the SenZ and SenZ-ability of RNA

Immunity, 2021
Some RNAs can assume a Z conformation, an unusual, left-handed turn. In this issue of Immunity, three studies report that mutations in the Zα-RNA binding domain of the adenosine deaminase ADAR1 are sufficient to induce autoinflammatory disease in mice, which models human Aicardí-Goutières syndrome, highlighting the important role of Z-RNA editing in ...
Thomas, Zillinger, Eva, Bartok
openaire   +2 more sources

ADAR1 and its implications in cancer development and treatment

Trends in Genetics, 2022
The family of adenosine deaminases acting on RNA (ADARs) regulates global gene expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded RNA (dsRNA) and through interacting with RNA and other proteins. ADARs play important roles in development and disease, including an increasing connection to cancer progression.
Allison R, Baker, Frank J, Slack
openaire   +2 more sources