Results 131 to 140 of about 4,773 (159)

ADAR1 Is Essential For Erythroid Development

Blood, 2013
Abstract Understanding the mechanisms controlling erythroid differentiation may allow therapeutic regulation of erythropoiesis. Focus so far has concentrated on the roles of transcription factors in determining erythroid fate, however one mechanism of gene regulation that has been poorly explored is that of direct modification of RNA. It
Brian Liddicoat, Jochen Hartner, Alistair Chalk, Jun Lu, Stuart H. Orkin, Carl R Walkley   +5 more
openaire   +1 more source

ADAR1 and ZBP1 in innate immunity, cell death, and disease

Trends in Immunology, 2023
ADAR1 and ZBP1 are the only two mammalian proteins that contain Zα domains, which are thought to bind to nucleic acids in the Z-conformation. These two molecules are crucial in regulating diverse biological processes. While ADAR1-mediated RNA editing supports host survival and development, ZBP1-mediated immune responses provide host defense against ...
Rajendra Karki, Thirumala-Devi Kanneganti   +1 more
openaire   +2 more sources

In search of critical dsRNA targets of ADAR1

Trends in Genetics
Recent studies have underscored the pivotal role of adenosine-to-inosine RNA editing, catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, the specific ADAR1 editing targets crucial for this regulatory function remain elusive.
Erez Y. Levanon, Roni Cohen-Fultheim, Eli Eisenberg   +2 more
openaire   +2 more sources

SINEs of cancer therapy success without ADAR1

Nature Reviews Molecular Cell Biology, 2020
RNA editing by ADAR1 destabilizes epigenetic-treatment-induced retrotransposon stem–loops and thus dampens the immune response to the treatment, suggesting that ADAR1 could be a therapeutic target in combination with epigenetic therapy.
openaire   +2 more sources

Characterization of ADAR1-mediated modulation of gene expression

Biochemical and Biophysical Research Communications, 2008
Conversion of adenosine into inosine in RNA molecules constitutes an important post-transcriptional mechanism for generating transcript diversity and is catalyzed by adenosine deaminases acting on RNA (ADARs). Intriguingly, we observed that the editing enzyme ADAR1 enhances reporter gene expression in a cellular, plasmid-based system.
Willemijn M, Gommans, Stefan, Maas
openaire   +2 more sources

Regulation of ADAR1 expression

2005
Ét gen kan kode for flere beslægtede proteiner, og reguleringen af dette sker bl.a. på RNA niveau. De livsnødvendige ADAR enzymer kan ændre på et RNA’s egenskaber ved en proces, der kaldes editering. Aktiviteten af en række receptorer i centralnervesystemet kontrolleres af ADAR enzymerne vha. nøje regulerede processer.
openaire   +1 more source

Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1

Immunity, 2021
Jorge Henao-Mejía, Carmela Sidrauski, Daniel B Stetson   +2 more
exaly  

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

Cell Reports, 2021
Rajendra Karki, Balamurugan Sundaram, Bhesh Raj Sharma   +2 more
exaly  

Adar1 restricts line-1 retrotransposition

2017
Adenosine deaminases acting on RNA (ADARs) are enzymes that catalyze the hydrolytic deamination of Adenosine (A) to Inosine (I) (AàI) in double-stranded RNA (dsRNA) substrates. This process is called RNA editing. In literature there are many studies describing ADAR1 as regulator of the replication of different viruses, exerting either a proviral or ...
openaire   +2 more sources

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses

Immunity, 2021
Rachel E Rigby, George R Young, Astrid Korning Hvidt   +2 more
exaly