Results 71 to 80 of about 7,998 (203)

ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis

Redox Biology, 2023
Astrocytes affect stroke outcomes by acquiring functionally dominant phenotypes. Understanding molecular mechanisms dictating astrocyte functional status after brain ischemia/reperfusion may reveal new therapeutic strategies.
Dunpeng Cai, Mikayla Fraunfelder, Ken Fujise, Shi-You Chen   +3 more
doaj   +1 more source

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis [PDF]

, 2018
Background Paraspeckles are subnuclear bodies assembled on a long non-coding RNA (lncRNA) NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic lateral sclerosis (ALS) patients has been reported but underlying mechanisms are unknown ...
Tatyana A. Shelkovnikova, Michail S. Kukharsky, Haiyan An, Pasquale Dimasi, Svetlana Alexeeva, Osman Shabir, Paul R. Heath, Vladimir L. Buchman, AE Renton, M DeJesus-Hernandez, J Sreedharan, S Lattante, M Neumann, T Arai, AH Fox, T Naganuma, CM Clemson, S Hennig, H Sunwoo, T Hirose, K Imamura, Z Zhang, L Jiang, H Choudhry, D Chakravarty, C Adriaens, Y Nishimoto, S Nakagawa, S Thomas-Jinu, TA Shelkovnikova, A Chesi, HJ Kim, JR Tollervey, M Polymenidou, MS Kukharsky, L Cong, TA Shelkovnikova, AE Renton, Y Kawahara, E Buratti, H Ota, M Morlando, GS Tan, C Lagier-Tourenne, TK Saldi, E White, SR Heras, BJ Liddicoat, F Weber, H Kaneko, M Marullo, SJ Marciniak, GJ Seo, LL Chen, S Melo, G Shan, A Emde, IE Schor, T Misteli, T Yamazaki, C Figueroa-Romero, A Freischmidt, E Gascon, EF Goodall, C Eitan, D Campos-Melo, S Bottini, A Heyam, V Tarallo, NM Mannion, A Ruggieri, S Porta, W Li, TP Hurst, KB Chiappinelli, RA Elbarbary, G Barry, F Zhang, JA West   +78 more
core   +3 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Zalpha-domains: At the intersection between RNA editing and innate immunity [PDF]

, 2012
The involvement of A to I RNA editing in antiviral responses was first indicated by the observation of genomic hyper-mutation for several RNA viruses in the course of persistent infections.
Athanasiadis, Alekos
core   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress

Drug Design, Development and Therapy, 2018
Yun Jiang,1 Zhancheng Wang,1 Xu Chen,1 Wei Wang,1 Xiaowei Wang2 1Department of Cardiology, The Eighth People’s Hospital of Shanghai, Shanghai 200233, China; 2Shanghai Weiang Info Tech Ltd., Shanghai 200233, China Background: The adenosine ...
Jiang Y, Wang Z, Chen X, Wang W, Wang X
doaj  

Differential Enzymatic Activity of Rat ADAR2 Splicing Variants Is Due to Altered Capability to Interact with RNA in the Deaminase Domain [PDF]

, 2018
In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process.
Barbon, Alessandro, Bonini, Daniela, Colombi, Marina, Filippini, Alice, Gangemi, Fabrizio, Giacopuzzi, Edoardo, La Via, Luca   +6 more
core   +2 more sources

Exploring Diagnostic Challenges: A Case Report Commentary on “Solving a Diagnostic Dilemma in a Patient With Periodic Fever—When the Pieces of the Puzzle Finally Fit”

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT This case highlights the diagnostic challenge of distinguishing periodic fever syndromes with prominent neurological features from interferonopathies. While the absence of specific features on MRI/MRA and SAVI reduces the likelihood of certain subtypes, genetic evaluation involving interferon pathway genes remains important.
Fatih Kelesoglu, Adem Polat
wiley   +1 more source

Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway

Experimental Hematology & Oncology
Background A-to-I RNA editing is an abundant post-transcriptional modification event in hepatocellular carcinoma (HCC). Evidence suggests that adenosine deaminases acting on RNA 1 (ADAR1) correlates to oxidative stress that is a crucial factor of HCC ...
Houhong Wang, Xiaoyu Wei, Lu Liu, Junfeng Zhang, Heng Li   +4 more
doaj   +1 more source

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. [PDF]

, 2019
We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the
Chen, Genghao, Ganesh, Ashwin, Katrekar, Dhruva, Mali, Prashant, Meluzzi, Dario, Shih, Yu-Ru, Varghese, Shyni, Worlikar, Atharv   +7 more
core   +1 more source