Results 141 to 150 of about 1,976 (156)

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders [PDF]

, 2019
al., et, Constantino, John N., Fassi, Emily, Shinawi, Marwan   +3 more
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El mal processament del RNA : en el cor de l'Esclerosi Lateral Amiotròfica [PDF]

, 2013
Ramon Gurrea, Elies, Universitat Autònoma de Barcelona. Facultat de Biociències   +1 more
core  

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Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis

The FASEB Journal, 2010
ABSTRACT Mammalian RNA editing catalyzed by adenosine deaminases acting on RNA (ADARs) ADAR1 and ADAR2 plays pivotal roles in the brain through functional modifications of neurotransmitter receptors and ion channels. We have demonstrated previously that RNA editing by ADAR2 is regulated metabolically in pancreatic
Liu, Yang, Liyun, Zhao, Zhenji, Gan, Zixuan, He, Jingyue, Xu, Xiang, Gao, Xiaorui, Wang, Weiping, Han, Liangyi, Chen, Tao, Xu, Wenjun, Li, Yong, Liu   +11 more
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Hyaluronidase-Dependent Changes of ADAR2 in Mice Hippocampal Cell Cultures

2021
The extracellular matrix plays an important role in brain function. Recent findings suggest that disruption of hyaluronan-based extracellular matrix can cause seizure-like activity (Vedunova et al., 2013). Epilepsy can be characterized by an excessive influx of Ca2+ ions through (Ca2+) permeable AMPA receptors, which may, in certain circumstances ...
V.I. Pershin, N.S. Maksimova, E.L. Guryev, A.A. Babaev, I.V. Mukhina   +4 more
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ADAR2 Regulates Malignant Behaviour of Mesothelioma Cells Independent of RNA-editing Activity

Anticancer Research, 2020
Malignant pleural mesothelioma (MPM) is an intractable cancer, and causes of its malignant transformation are not well known. Adenosine deaminase acting on RNA (ADAR) is an RNA-editing enzyme that converts adenosine into inosine in double-stranded RNAs potentially involved in malignant development.To examine the role of ADAR1 and ADAR2 in MPM, small ...
Ken-Ichiro, Sakata, Kojiro, Maeda, Nozomi, Sakurai, Shanshang, Liang, Seitaro, Nakazawa, Kazuyoshi, Yanagihara, Takanori, Kubo, Hironori, Yoshiyama, Yoshimasa, Kitagawa, Jun-Ichi, Hamada, Hisashi, Iizasa   +10 more
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Double-Stranded RNA Adenosine Deaminases ADAR1 and ADAR2 Have Overlapping Specificities

Biochemistry, 2000
Adenosine deaminases that act on RNA (ADARs) deaminate adenosines to produce inosines within RNAs that are largely double-stranded (ds). Like most dsRNA binding proteins, the enzymes will bind to any dsRNA without apparent sequence specificity. However, once bound, ADARs deaminate certain adenosines more efficiently than others.
K A, Lehmann, B L, Bass
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Unique nuclear vacuoles in the motor neurons of conditional ADAR2-knockout mice

Brain Research, 2014
A reduction in adenosine deaminase acting on RNA 2 (ADAR2) activity causes the death of spinal motor neurons specifically via the GluA2 Q/R site-RNA editing failure in sporadic amyotrophic lateral sclerosis (ALS). We studied, over time, the spinal cords of ADAR2-knockout mice, which are the mechanistic model mice for sporadic ALS, using homozygous ...
Shoichi, Sasaki, , Takenari Yamashita, Takuto, Hideyama, Shin, Kwak   +3 more
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Structural analysis of human ADAR2-RNA complexes by X-ray crystallography [PDF]

Adenosine deaminases acting on RNAs (ADARs) are a class of RNA editing enzymes found in metazoa that catalyze the hydrolytic deamination of adenosine to inosine in duplexed RNA. Inosine is a nucleotide that can base pair with cytidine, therefore, inosine is interpreted by cellular processes as guanosine. ADARs are functionally important in RNA recoding
Campbell, Kristen B, Cheng, Jeff, Mendoza, Herra G, Karki, Agya, Beal, Peter A, Fisher, Andrew J   +5 more
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Harnessing Human ADAR2 for Site-Directed RNA Editing

2018
The catalytic deamination of adenosine to inosine is an essential posttranscriptional RNA modification. Since Inosine is biochemically read as guanosine, site-specific A-to-I RNA editing results in substitution of single amino acids and can lead to changes in processing and regulation of transcripts.
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ADAR2-mediated Q/R editing of GluA2 in homeostatic synaptic plasticity

Science Signaling
Homeostatic synaptic plasticity is a negative feedback mechanism through which neurons modify their synaptic strength to counteract chronic increases or decreases in activity. In response to activity deprivation, synaptic strength is enhanced by increasing the number of AMPA receptors (AMPARs), particularly Ca 2 ...
Lucy Peterson, Richard Coca, Shreya Parikh, Katrina McCarthy, Heng-Ye Man   +4 more
openaire   +2 more sources