Results 181 to 190 of about 4,066 (198)

Nucleoside Analogs in ADAR Guide Strands Enable Editing at 5'-G<u>A</u> Sites. [PDF]

Biomolecules
Manjunath A, Cheng J, Campbell KB, Jacobsen CS, Mendoza HG, Bierbaum L, Jauregui-Matos V, Doherty EE, Fisher AJ, Beal PA.   +9 more
europepmc   +1 more source

Advances in RNA modification in myocardial fibrosis (Review). [PDF]

Int J Mol Med
Wu X, Wang R, Chen X, Wang K.
europepmc   +1 more source

ADAR Therapeutics as a New Tool for Personalized Medicine. [PDF]

Genes (Basel)
Bertoli M, La Via L, Barbon A.
europepmc   +1 more source

Distinguishing self from non-self RNA by editing-specific inosine patterns

Varada R, Leuchtenberger A, Vesely C, Kaczmarek B, Khosravi HM, Mandl T, Milanovic K, Tamizkar KH, Rajendra V, Senoner H, Steinbichl L, Borojevic M, Sombke A, Schmidt K, Eckhard M, Hofacker I, Walkley C, Heraud-Farlow J, Picardi E, Bernecky C, Jantsch M.   +20 more
europepmc   +1 more source

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Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis

The FASEB Journal, 2010
ABSTRACT Mammalian RNA editing catalyzed by adenosine deaminases acting on RNA (ADARs) ADAR1 and ADAR2 plays pivotal roles in the brain through functional modifications of neurotransmitter receptors and ion channels. We have demonstrated previously that RNA editing by ADAR2 is regulated metabolically in pancreatic
Liu, Yang, Liyun, Zhao, Zhenji, Gan, Zixuan, He, Jingyue, Xu, Xiang, Gao, Xiaorui, Wang, Weiping, Han, Liangyi, Chen, Tao, Xu, Wenjun, Li, Yong, Liu   +11 more
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Hyaluronidase-Dependent Changes of ADAR2 in Mice Hippocampal Cell Cultures

2021
The extracellular matrix plays an important role in brain function. Recent findings suggest that disruption of hyaluronan-based extracellular matrix can cause seizure-like activity (Vedunova et al., 2013). Epilepsy can be characterized by an excessive influx of Ca2+ ions through (Ca2+) permeable AMPA receptors, which may, in certain circumstances ...
V.I. Pershin, N.S. Maksimova, E.L. Guryev, A.A. Babaev, I.V. Mukhina   +4 more
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ADAR2 Regulates Malignant Behaviour of Mesothelioma Cells Independent of RNA-editing Activity

Anticancer Research, 2020
Malignant pleural mesothelioma (MPM) is an intractable cancer, and causes of its malignant transformation are not well known. Adenosine deaminase acting on RNA (ADAR) is an RNA-editing enzyme that converts adenosine into inosine in double-stranded RNAs potentially involved in malignant development.To examine the role of ADAR1 and ADAR2 in MPM, small ...
Ken-Ichiro, Sakata, Kojiro, Maeda, Nozomi, Sakurai, Shanshang, Liang, Seitaro, Nakazawa, Kazuyoshi, Yanagihara, Takanori, Kubo, Hironori, Yoshiyama, Yoshimasa, Kitagawa, Jun-Ichi, Hamada, Hisashi, Iizasa   +10 more
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Double-Stranded RNA Adenosine Deaminases ADAR1 and ADAR2 Have Overlapping Specificities

Biochemistry, 2000
Adenosine deaminases that act on RNA (ADARs) deaminate adenosines to produce inosines within RNAs that are largely double-stranded (ds). Like most dsRNA binding proteins, the enzymes will bind to any dsRNA without apparent sequence specificity. However, once bound, ADARs deaminate certain adenosines more efficiently than others.
K A, Lehmann, B L, Bass
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Unique nuclear vacuoles in the motor neurons of conditional ADAR2-knockout mice

Brain Research, 2014
A reduction in adenosine deaminase acting on RNA 2 (ADAR2) activity causes the death of spinal motor neurons specifically via the GluA2 Q/R site-RNA editing failure in sporadic amyotrophic lateral sclerosis (ALS). We studied, over time, the spinal cords of ADAR2-knockout mice, which are the mechanistic model mice for sporadic ALS, using homozygous ...
Shoichi, Sasaki, , Takenari Yamashita, Takuto, Hideyama, Shin, Kwak   +3 more
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