Results 101 to 110 of about 6,398,385 (224)
Difficult‐to‐Treat Epilepsy With Developmental Implications
Annals of the Child Neurology Society, EarlyView.
Samuel Kamoroff +2 more
wiley +1 more source
American Journal of Medical Genetics Part A, Volume 197, Issue 9, September 2025.ABSTRACT Genitopatellar syndrome (GPS) and Say‐Barber‐Biesecker‐Young‐Simpson Syndrome (SBBYSS) are clinically distinct neurodevelopmental disorders caused by monoallelic pathogenic variants in KAT6B. In some cases, GPS and SBBYSS features can overlap, determining an intermediate phenotype.
Vittorio Maglione +12 more
wiley +1 more source
Pan-cancer analysis of ADAR1 with its prognostic relevance in low-grade glioma
ImmunobiologyADAR1, known as the primary enzyme for adenosine-to-inosine RNA editing, has recently been implicated in cancer development through both RNA editing-dependent and −independent pathways.
Qin Yang, Xin Li
doaj +1 more source
Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer
BioEssays, Volume 47, Issue 8, August 2025.Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley +1 more source
Exploring the untapped potential of single‐cell and spatial omics in plant biology
New Phytologist, Volume 247, Issue 3, Page 1098-1116, August 2025.Summary Advances in single‐cell and spatial omics technologies have revolutionised biology by revealing the diverse molecular states of individual cells and their spatial organization within tissues. The field of plant biology has widely adopted single‐cell transcriptome and chromatin accessibility profiling and spatial transcriptomics, which extend ...
Tatsuya Nobori
wiley +1 more source
Advanced Science, Volume 12, Issue 28, July 24, 2025.CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi +8 more
wiley +1 more source
Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases
MedComm, Volume 6, Issue 7, July 2025.Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar +10 more
wiley +1 more source
Natural Antioxidants as Regulators of Circular RNA Expression and Function
WIREs RNA, Volume 16, Issue 4, July/August 2025.Natural antioxidants found in food can modulate circular RNA activity, offering a novel strategy to counteract oxidative stress and its related diseases, including cardiovascular disorders, diabetes, and cancer. This emerging connection between diet and gene regulation holds promising potential for both therapy and prevention.
Aseela Fathima +6 more
wiley +1 more source
iScience, 2020 Summary: Both UV-cross-linking and immunoprecipitation (CLIP) and RNA editing (TRIBE) can identify the targets of RNA-binding proteins. To evaluate false-positives of CLIP and TRIBE, endogenous β-actin mRNA was tagged with MS2 stem loops, making it the ...
Jeetayu Biswas +4 more
doaj +1 more source