Results 101 to 110 of about 6,770,889 (217)

High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse [PDF]

, 2005
Jie Hong, Zhikang Qian, Shuiyuan Shen, Taishan Min, Chang Tan, Jianfeng Xu, Yingchun Zhao, Weida Huang   +7 more
openalex   +1 more source

A pipeline for identifying guide RNA sequences that promote RNA editing of nonsense mutations that cause inherited retinal diseases

Molecular Therapy: Nucleic Acids
Adenosine deaminases acting on RNA (ADARs) are endogenous enzymes catalyzing the deamination of adenosines to inosines, which are then read as guanosines during translation. This ability to recode makes ADAR an attractive therapeutic tool to edit genetic
Nina Schneider, Ricky Steinberg, Amit Ben-David, Johanna Valensi, Galit David-Kadoch, Zohar Rosenwasser, Eyal Banin, Erez Y. Levanon, Dror Sharon, Shay Ben-Aroya   +9 more
doaj   +1 more source

Dysregulated RNA editing of EIF2AK2 in polycystic ovary syndrome: clinical relevance and functional implications

BMC Medicine
Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive ages. Our previous study has implicated a possible link between RNA editing and PCOS, yet the actual role of RNA editing, its association with ...
Fan-Sheng Kong, Junjie Feng, Jin-Ping Yao, Yinghua Lu, Tao Guo, Meng Sun, Chun-Yan Ren, Yun-Yun Jin, Yaping Ma, Jian-Huan Chen   +9 more
doaj   +1 more source

ADBP-1 Regulates an ADAR RNA-Editing Enzyme to Antagonize RNA-Interference-Mediated Gene Silencing in Caenorhabditis elegans [PDF]

, 2008
Hiromitsu Ohta, Manabi Fujiwara, Yasumi Ohshima, Takeshi Ishihara   +3 more
openalex   +1 more source

Useful ‘junk': Alu RNAs in the human transcriptome [PDF]

, 2018
.: Alu elements are the most abundant repetitive elements in the human genome; they have amplified by retrotransposition to reach the present number of more than one million copies.
Häsler, J., Samuelsson, T., Strub, K.
core  

Diverse selective regimes shape genetic diversity atADARgenes and at their coding targets [PDF]

, 2015
Diego Forni, Alessandra Mozzi, Chiara Pontremoli, Jacopo Vertemara, Uberto Pozzoli, Mara Biasin, Nereo Bresolin, Mario Clerici, Rachele Cagliani, Manuela Sironi   +9 more
openalex   +1 more source

Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes [PDF]

, 1999
R Hough, Arunth T. Lingam, Brenda Bass
openalex   +1 more source

An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer [PDF]

, 2017
Lihua Qi, Yangyang Song, Tim Hon Man Chan, Henry Yang, Chi Ho Lin, Daryl Jin Tai Tay, HuiQi Hong, Sze Jing Tang, Kar Tong Tan, Xi Huang, Jaymie Siqi Lin, Vanessa Hui En Ng, Julien Jean Pierre Maury, Daniel G. Tenen, Leilei Chen   +14 more
openalex   +1 more source

SAGE: Sequential Attribute Generator for Analyzing Glioblastomas using Limited Dataset

, 2020
While deep learning approaches have shown remarkable performance in many imaging tasks, most of these methods rely on availability of large quantities of data. Medical image data, however, is scarce and fragmented.
Allen, Jason, Bhanu, Bir, Bhanu, Shiv, Jonnalagedda, Padmaja, Min, Taejin L., Weinberg, Brent   +5 more
core  

Integrative PANoptosis gene profiling reveals prognostic and therapeutic insights in prostate cancer

Biomolecules & Biomedicine
Prostate cancer (PCa) remains a significant global health challenge, representing the most common solid tumor in men and the fifth leading cause of cancer-related death. Despite therapeutic advances, achieving a definitive cure remains difficult.
Yi Wang, Yiheng Du, Xizhi Wang, Jiang Yu, Qing Gu, Guangquan Yuan, Yifei Zhu, Liyang Gu, Jun Ouyang   +8 more
doaj   +1 more source