Results 91 to 100 of about 2,533,373 (163)
ADAR therapy: a breakthrough against genetic disorders
Adenosine Deaminases Acting on RNA (ADAR) catalyze the transformation of adenosine (A) into inosine (I) within double-stranded RNA (dsRNA) structures. This process, known as A-I RNA editing, plays a crucial role in regulating gene expression, maintaining
G. Carini +9 more
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BMC MedicineBackground Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive ages. Our previous study has implicated a possible link between RNA editing and PCOS, yet the actual role of RNA editing, its association with ...
Fan-Sheng Kong +9 more
doaj +1 more source
Two codes of RNA editing by deamination in human diseases
Experimental and Molecular MedicineRNA editing is a post-transcriptional modification that expands transcriptomic and proteomic diversity. Advances in high-throughput sequencing across a broad range of biological and pathological contexts have enabled systematic identification of editing ...
Dong Jun Min +3 more
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Phylogenetic and structural analysis of Hydra ADAR [PDF]
Adenosine deaminases acting on RNAs (ADARs) perform adenosine-to-inosine (A-to-I) RNA editing for essential biological functions. While studies of editing sites in diverse animals have revealed unique biological roles of ADAR editing including ...
Mozumder, Sukanya +8 more
core +1 more source
Adaptive evolution of A-to-I auto-editing site in Adar of eusocial insects
BMC GenomicsBackground Adenosine-to-inosine (A-to-I) RNA editing is a co-/post-transcriptional modification introducing A-to-G variations in RNAs. There is extensive discussion on whether the flexibility of RNA editing exerts a proteomic diversification role, or it ...
Caiqing Zheng, Jiyao Liu, Yuange Duan
doaj +1 more source
mBioSensing of viral double-stranded RNA (dsRNA) by MDA5 triggers abundant but transient interferon-stimulated gene (ISGs) expression. If dsRNA synthesis is made persistent by transgenically expressing a picornaviral RNA-dependent RNA polymerase (RdRp) in ...
Caitlin M. Miller +7 more
doaj +1 more source
Gene Therapy for Allergic Diseases
, 2010 Allergic diseases, such as allergic asthma, allergic rhinitis, atopic dermatitis, conjunctivitis, urticaria, food allergy, and/or anaphylaxis, are associated with the skewing of immune responses towards a T helper 2 ( TH2) phenotype, resulting in ...
莊雅惠;楊曜旭;江伯倫 +1 more
core +1 more source
Integrative PANoptosis gene profiling reveals prognostic and therapeutic insights in prostate cancer
Biomolecules & BiomedicineProstate cancer (PCa) remains a significant global health challenge, representing the most common solid tumor in men and the fifth leading cause of cancer-related death. Despite therapeutic advances, achieving a definitive cure remains difficult.
Yi Wang +8 more
doaj +1 more source
ADAR Enzymes as a Treatment for Cystic Fibrosis Cases Caused by Nonsense Mutations
Literature suggests that ADAR enzymes are capable of editing human RNA to treat genetic diseases caused by nonsense mutations. Recently, scientists have been investigating the use of ADAR enzymes to treat cystic fibrosis cases that are caused by nonsense
Fratarcangeli, Josie
core +1 more source
Gene and RNA Editing: Revolutionary Approaches to Treating Diseases
MedCommGene editing and RNA editing technologies are advancing modern medicine by enabling precise manipulation of genetic information at the DNA and RNA levels, respectively. The third‐generation gene editing tools, particularly Clustered regularly interspaced
Jia‐Mei Li +6 more
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