Results 91 to 100 of about 15,501 (191)

Pan-cancer analysis of ADAR1 with its prognostic relevance in low-grade glioma

Immunobiology
ADAR1, known as the primary enzyme for adenosine-to-inosine RNA editing, has recently been implicated in cancer development through both RNA editing-dependent and −independent pathways.
Qin Yang, Xin Li
doaj   +1 more source

Host Immune Response Driving SARS-CoV-2 Evolution

Viruses, 2020
The transmission and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of paramount importance in controlling and combating the coronavirus disease 2019 (COVID-19) pandemic.
Rui Wang, Yuta Hozumi, Yong-Hui Zheng, Changchuan Yin, Guo-Wei Wei   +4 more
doaj   +1 more source

Inhibiting ADAR1‐Mediated Excessive Epigenetic A‐to‐I RNA Editing Improves the Immune Microenvironment and Increases Sensitivity to Immunotherapy in Lung Adenocarcinoma

MedComm, Volume 7, Issue 3, March 2026.
This study investigated the potential of inhibiting ADAR1 which catalyzed excessive A‐to‐I RNA editing as a therapeutic strategy to augment the effectiveness of immunotherapy in LUAD. Mouse models demonstrated that inhibiting ADAR1 in tumor cells significantly improved the immune microenvironment by increasing PD‐L1 expression and CD8+ T‐cell ...
Sihui Wang, Sufei Zheng, Chengming Liu, Chaoqi Zhang, Xinfeng Wang, Zhanyu Wang, Yan Wang, Xiaoli Feng, Qi Xue, Nan Sun, Jie He   +10 more
wiley   +1 more source

An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing

Nature Communications
Custom RNA base editing exploiting the human Adenosine Deaminase Acting on RNA (ADAR) enzyme may enable therapeutic gene editing without DNA damage or use of foreign proteins.
Susan M. Byrne, Stephen M. Burleigh, Robert Fragoza, Yue Jiang, Yiannis Savva, Ricky Pabon, Evan Kania, Joseph Rainaldi, Andrew Portell, Prashant Mali, Adrian W. Briggs   +10 more
doaj   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells

Molecular Metabolism
Objective: A longstanding question in type 1 diabetes (T1D) research pertains to the selective loss of β-cells whilst neighboring islet α-cells remain unharmed.
Shani Peleg, Liza Zamashanski, Jonathan Belin, Roy Novoselsky, Roni Cohen-Fultheim, Udi Ehud Knebel, Benjamin Glaser, Shalev Itzkovitz, Klaus H. Kaestner, Alvin C. Powers, Erez Y. Levanon, Agnes Klochendler, Yuval Dor   +12 more
doaj   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, Volume 2, Issue 1, Page 106-129, March 2026.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Inheritance patterns in citation networks reveal scientific memes

, 2014
Memes are the cultural equivalent of genes that spread across human culture by means of imitation. What makes a meme and what distinguishes it from other forms of information, however, is still poorly understood.
A Hulth, A L Barab�si, A M Petersen, A Mazloumian, D Bourigault, D Chavalarias, D J De Solla Price, D Wang, Dirk Helbing, E Adar, E G Altmann, F Radicchi, F Radicchi, H E Stanley, J A Evans, J B Michel, J E Hirsch, J Leskovec, J P Gleeson, K B�rner, K B�rner, L Weng, M Bastian, M Conover, M E J Newman, M Gomez Rodriguez, M P Simmons, M Perc, Matjaz Perc, N A Christakis, O Penner, R Guimer�, R K Merton, R K Pan, R The Dawkins, S Martin, S Milojevi�cmilojevi�c, S Redner, Tobias Kuhn   +38 more
core   +2 more sources

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Senescence in Normal Human Dermal Fibroblasts Induces Heterogeneous Fibril Orientation of Type I Collagen Through Downregulation of BMP‐1

Genes to Cells, Volume 31, Issue 2, March 2026.
Senescent fibroblasts construct collagen fibrils, whose orientation is disturbed. We found that senescent fibroblasts downregulate C‐pp cleavage enzymes BMP‐1 and PCPE‐1, which results in downregulation of C‐pp cleavage. This was demonstrated by conducting BMP‐1 knockdown experiments in young fibroblasts, which led to a disturbance in the orientation ...
Koji Moriya, Yuki Shibaike, Katsura Sano, Toshiaki Tanaka   +3 more
wiley   +1 more source