Results 101 to 110 of about 15,501 (191)

Narrowing down the candidates of beneficial A-to-I RNA editing by comparing the recoding sites with uneditable counterparts

Nucleus
Adar-mediated adenosine-to-inosine (A-to-I) RNA editing mainly occurs in nucleus and diversifies the transcriptome in a flexible manner. It has been a challenging task to identify beneficial editing sites from the sea of total editing events.
Tianyou Zhao, Ling Ma, Shiwen Xu, Wanzhi Cai, Hu Li, Yuange Duan   +5 more
doaj   +1 more source

VIRMA promotes NSCLC progression by modifying ADAR m6A and increasing the activity of the TGF-β signaling pathway

Scientific Reports
The N6-methyladenosine (m6A) modification is prevalently found in mRNAs and lncRNAs in various eukaryotic organisms, playing a crucial role in biological processes.
Yuchen Shan, Yongfei Fan, Xudong Zhu, Yi Zhao, Xiangseng Liu, Xiaoyu Duan, Zhaojia Gao, Ming Lou, Kai Yuan   +8 more
doaj   +1 more source

The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogeneses

RNA Biology
The process of adenosine deaminase (ADAR)-catalyzed double-stranded RNA (dsRNA) Adenosine-to-Inosine (A-to-I) editing is essential for the correction of pathogenic mutagenesis, as well as the regulation of gene expression and protein function in mammals.
Wanqing Liu, Yufan Wu, Tong Zhang, Xiaobo Sun, Dean Guo, Zizhao Yang   +5 more
doaj   +1 more source

Link Prediction using Top-$k$ Shortest Distances

, 2017
In this paper, we apply an efficient top-$k$ shortest distance routing algorithm to the link prediction problem and test its efficacy. We compare the results with other base line and state-of-the-art methods as well as with the shortest path. Our results
Lebedev, Andrei, Lee, JooYoung, Mazzara, Manuel, Rivera, Victor   +3 more
core   +1 more source

The PSI-U1 snRNP interaction regulates male mating behavior in Drosophila

, 2016
Alternative pre-mRNA splicing (AS) is a critical regulatory mechanism that operates extensively in the nervous system to produce diverse protein isoforms.
Hilgers, V., Klibaite, U., Rio, D., Shaevitz, J., Taliaferro, J., Wang, Q.   +5 more
core   +1 more source

Epigenetics of Homocystinuria, Hydrogen Sulfide, and Circadian Clock Ablation in Cardiovascular–Renal Disease

Current Issues in Molecular Biology
Morning-time heart attacks are associated with an ablation in the sleep-time dip in blood pressure, the mechanism of which is unknown. The epigenetic changes are the hallmark of sleep and circadian clock disruption and homocystinuria (HHcy).
Suresh C. Tyagi
doaj   +1 more source

The diverse functions of the ADAR enzymes : Editing and editing-independent effects on gene expression

, 2023
The adenosine deaminase acting on RNA (ADAR) family of enzymes consists of three members (ADAR1-3). These enzymes are responsible for the deamination of adenosine into inosine in double-stranded RNA, one of the most common RNA modifications in mammals.
openaire   +1 more source

A pipeline for identifying guide RNA sequences that promote RNA editing of nonsense mutations that cause inherited retinal diseases

Molecular Therapy: Nucleic Acids
Adenosine deaminases acting on RNA (ADARs) are endogenous enzymes catalyzing the deamination of adenosines to inosines, which are then read as guanosines during translation. This ability to recode makes ADAR an attractive therapeutic tool to edit genetic
Nina Schneider, Ricky Steinberg, Amit Ben-David, Johanna Valensi, Galit David-Kadoch, Zohar Rosenwasser, Eyal Banin, Erez Y. Levanon, Dror Sharon, Shay Ben-Aroya   +9 more
doaj   +1 more source

Dysregulated RNA editing of EIF2AK2 in polycystic ovary syndrome: clinical relevance and functional implications

BMC Medicine
Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive ages. Our previous study has implicated a possible link between RNA editing and PCOS, yet the actual role of RNA editing, its association with ...
Fan-Sheng Kong, Junjie Feng, Jin-Ping Yao, Yinghua Lu, Tao Guo, Meng Sun, Chun-Yan Ren, Yun-Yun Jin, Yaping Ma, Jian-Huan Chen   +9 more
doaj   +1 more source

ADARs mediate distinct RNA editing activity and gene regulation in the Caenorhabditis elegans germline

Abstract Tissues rely on unique landscapes of gene regulation to allow the organism to correctly develop, function, and respond to changes. One component of these gene regulatory networks is RNA Binding Proteins (RBPs) which bind and modify RNA molecules leading to changes in the cellular fate of transcripts.
Emily A. Erdmann, Heather A. Hundley
openaire   +1 more source