Results 71 to 80 of about 15,501 (191)
High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse [PDF]
Biochemical Journal, 2005 RNAi (RNA interference) is a gene-silencing mechanism that is conserved in evolution from worm to human and has been a powerful tool for gene functional research. It has been clear that the RNAi effect triggered by endogenous or exogenous siRNAs (small interfering RNAs) is transient and dose-dependent.
Jie, Hong +7 more
openaire +2 more sources
ADAR1 Controls Macrophage Scavenging and Lipid‐Buffering Programs in Metabolic Tissues
European Journal of Immunology, Volume 56, Issue 4, April 2026.ADAR1 expression increase during monocyte‐to‐macrophage differentiation via an alternative transcription start site. Isoform‐specific ADAR1 activity governs key macrophage functions, including efferocytosis, endocytosis, lipid metabolism, and proliferation.
Achilleas Fardellas +20 more
wiley +1 more source
Population and allelic variation of A-to-I RNA editing in human transcriptomes. [PDF]
, 2017 BackgroundA-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Demirdjian, Levon +6 more
core +2 more sources
British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
Induction of 150‐kDa adenosine deaminase that acts on RNA (ADAR)‐1 gene expression in normal T lymphocytes by anti‐CD3‐ε and anti‐CD28 [PDF]
Immunology, 2007 SummaryWe and other investigators have demonstrated up‐regulation of the expression of the RNA‐editing gene 150‐kDa adenosine deaminase that acts on RNA (ADAR1) in systemic lupus erythematosus (SLE) T cells and B cells, peripheral blood mononuclear cells (PBMC), natural killer (NK) cells.
Dama, Laxminarayana +3 more
openaire +2 more sources
Link-Prediction Enhanced Consensus Clustering for Complex Networks
, 2015 Many real networks that are inferred or collected from data are incomplete due to missing edges. Missing edges can be inherent to the dataset (Facebook friend links will never be complete) or the result of sampling (one may only have access to a portion ...
Adar, Eytan +2 more
core +3 more sources
Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan +3 more
wiley +1 more source
Cell Reports, 2023 Summary: Variants of the RNA-editing enzyme ADAR1 cause Aicardi-Goutières syndrome (AGS), in which severe inflammation occurs in the brain due to innate immune activation.
Xinfeng Guo +6 more
doaj +1 more source
A-to-I RNA editing does not change with age in the healthy male rat brain [PDF]
, 2013 RNA editing is a post-transcriptional process, which results in base substitution modifications to RNA. It is an important process in generating protein diversity through amino acid substitution and the modulation of splicing events.
Andrew P. Holmes +3 more
core +1 more source
Advanced Science, Volume 13, Issue 18, 27 March 2026.This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang +11 more
wiley +1 more source