Results 71 to 80 of about 2,533,373 (163)

RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells

Molecular Metabolism
Objective: A longstanding question in type 1 diabetes (T1D) research pertains to the selective loss of β-cells whilst neighboring islet α-cells remain unharmed.
Shani Peleg, Liza Zamashanski, Jonathan Belin, Roy Novoselsky, Roni Cohen-Fultheim, Udi Ehud Knebel, Benjamin Glaser, Shalev Itzkovitz, Klaus H. Kaestner, Alvin C. Powers, Erez Y. Levanon, Agnes Klochendler, Yuval Dor   +12 more
doaj   +1 more source

Epigenetic‐Based Evidence for Distinct Effects of Age, Sex, and Experience in Developmental Critical Period Learning

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Although much is known about the encoding of experience, how the brain organizes neural circuits capable of learning and memory formation is largely unstudied. Canonical critical periods emerge from a convergence of maturation‐ and experience‐dependent processes.
Grant W. Kunzelman, Alice Batistuzzo, Sarah E. London   +2 more
wiley   +1 more source

Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Schematic illustration of four emerging CRISPR–Cas delivery platforms defined by distinct design principles and structural features: virus‐mimicking nanosystems (e.g., VLPs), cell‐derived extracellular vesicles, cell‐penetrating peptides, and stimuli‐responsive scaffolds. These platforms enable spatiotemporally controlled delivery of RNPs, mRNA, or DNA
Meijia Yang, Yiqiong Song, Ziyang Wang, Ke Chao, Lifeng Li, Xu Zhang, Xiaoran Duan, Chenglong Yu, Ruyue Xue, Jie Zhao   +9 more
wiley   +1 more source

Transcriptomic Evidence of Mitochondrial Double‐Stranded RNA Accumulation in Brain Aging and Alzheimer's Disease

Aging Cell, Volume 25, Issue 7, July 2026.
Mt‐dsRNA signatures increase in the human brain after midlife in parallel with disrupted mitochondrial RNA homeostasis and are further elevated in Alzheimer's disease, where they correlate with cognitive decline and neuropathology. These findings suggest that age‐related mitochondrial RNA dyshomeostasis may drive chronic inflammation and contribute to ...
Rachel L. Doser, Thomas J. LaRocca
wiley   +1 more source

Narrowing down the candidates of beneficial A-to-I RNA editing by comparing the recoding sites with uneditable counterparts

Nucleus
Adar-mediated adenosine-to-inosine (A-to-I) RNA editing mainly occurs in nucleus and diversifies the transcriptome in a flexible manner. It has been a challenging task to identify beneficial editing sites from the sea of total editing events.
Tianyou Zhao, Ling Ma, Shiwen Xu, Wanzhi Cai, Hu Li, Yuange Duan   +5 more
doaj   +1 more source

VIRMA promotes NSCLC progression by modifying ADAR m6A and increasing the activity of the TGF-β signaling pathway

Scientific Reports
The N6-methyladenosine (m6A) modification is prevalently found in mRNAs and lncRNAs in various eukaryotic organisms, playing a crucial role in biological processes.
Yuchen Shan, Yongfei Fan, Xudong Zhu, Yi Zhao, Xiangseng Liu, Xiaoyu Duan, Zhaojia Gao, Ming Lou, Kai Yuan   +8 more
doaj   +1 more source

The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogeneses

RNA Biology
The process of adenosine deaminase (ADAR)-catalyzed double-stranded RNA (dsRNA) Adenosine-to-Inosine (A-to-I) editing is essential for the correction of pathogenic mutagenesis, as well as the regulation of gene expression and protein function in mammals.
Wanqing Liu, Yufan Wu, Tong Zhang, Xiaobo Sun, Dean Guo, Zizhao Yang   +5 more
doaj   +1 more source

A-to-I RNA editing: current knowledge sources and computational approaches with special emphasis on non-coding RNA molecules

Frontiers in Bioengineering and Biotechnology, 2015
RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Giovanni eNigita, Dario eVeneziano, Alfredo eFerro   +2 more
doaj   +1 more source

Autorecoding A-to-I RNA editing sites in the Adar gene underwent compensatory gains and losses in major insect clades. [PDF]

RNA, 2023
Duan Y, Ma L, Song F, Tian L, Cai W, Li H.   +5 more
europepmc   +1 more source

Bridging Duchenne muscular dystrophy therapy from rhesus monkeys to patients

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Wenting Guo, Weizhi Ji, Yongchang Chen
wiley   +1 more source