Results 51 to 60 of about 2,533,373 (163)

ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing

Cell Reports, 2023
Summary: Variants of the RNA-editing enzyme ADAR1 cause Aicardi-Goutières syndrome (AGS), in which severe inflammation occurs in the brain due to innate immune activation.
Xinfeng Guo, Silvia Liu, Yi Sheng, Mazen Zenati, Timothy Billiar, Alan Herbert, Qingde Wang   +6 more
doaj   +1 more source

Prioritizing of industrial wastewater management processes using an integrated AHP–CoCoSo model: comparative and sensitivity analyses

, 2021
The increase in individuals’ consumption and needs and the rapid development of technology result in different types of industrial wastewaters. A vast majority of industrial wastewaters are harmful to humans and other animals, as well as the environment.
Adar, Tuba, Adar, Elanur, Delice, Elif Kılıç   +2 more
core   +1 more source

The conserved protein kinase-A target motif in synapsin of Drosophila is effectively modified by pre-mRNA editing

BMC Neuroscience, 2006
Background Synapsins are abundant synaptic vesicle associated phosphoproteins that are involved in the fine regulation of neurotransmitter release.
Buchner Erich, Zars Troy, Werner Ursula, Hoppe Jürgen, Nieratschker Vanessa, Diegelmann Sören   +5 more
doaj   +1 more source

Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development. [PDF]

PLoS ONE, 2014
Oligophrenin-1 (OPHN1) encodes for a Rho-GTPase-activating protein, important for dendritic morphogenesis and synaptic function. Mutations in this gene have been identified in patients with X-linked intellectual disability associated with cerebellar ...
Sabina Barresi, Sara Tomaselli, Alekos Athanasiadis, Federica Galeano, Franco Locatelli, Enrico Bertini, Ginevra Zanni, Angela Gallo   +7 more
doaj   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1702-1710, August 2026.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

ADAR RNA editing below the backbone

, 2017
ADAR RNA editing enzymes (adenosine deaminases acting on RNA) that convert adenosine bases to inosines were first identified biochemically 30 years ago.
Anzer Khan, Dragana Vukic, Liam Keegan, Mary O'Connell   +3 more
core   +1 more source

The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster [PDF]

, 2013
RNA editing by deamination of specific adenosine bases to inosines during pre-mRNA processing generates edited isoforms of proteins. Recoding RNA editing is more widespread in Drosophila than in vertebrates. Editing levels rise strongly at metamorphosis,
Baines, Richard A., Richard A. Baines, Overton, Ian M, Overton, Ian M., Li, Xianghua, O'Connell, Mary A, Ian M. Overton, Overton, Ian M; id_orcid, Baines, Richard A.; id_orcid, Xianghua Li, Keegan, Liam P, O'Connell, Mary A., Mary A. O’connell, O'Connell, Mary A.,, Li, Xianghua; id_orcid, Baines, Richard A, Liam P. Keegan, Keegan, Liam P.   +17 more
core   +1 more source

ADAR-1 editing and DAg accumulation.

A) Schematic representation of the ADAR-1 locus targeted by the different sgRNAs for KO generation (Upper) and the ADAR-1 isoforms, p110 and p150, including the functional domains for each isoform and the localization of the sgRNAs targeted regions ...
Udo Hetzel (162762), Thomas F. Baumert (15291307), Valérie Courgnaud (18107241), Carine Chavey (369936), Eloi Verrier (5424479), Jussi Hepojoki (410961), Nora Goldmann (18107238), Joe McKellar (10156938), Damien Gregoire (18107244), Jeremy Dufourt (18107235), Dieter Glebe (421759), Pierre Khalfi (7868252), Leonora Szirovicza (18107232), Karim Majzoub (6176003), Giovanni Merolla (18107223), Zoé Denis (13124446), José Ursic-Bedoya (18107226), Kaku Goto (332712), Lena Soppa (18107229), Cedric Leyrat (5656741)   +19 more
core   +1 more source

Circular RNA circBbs9 promotes PM2.5-induced lung inflammation in mice via NLRP3 inflammasome activation

Environment International, 2020
Fine particulate matter (PM2.5) is one of the most important components of environmental pollutants, and is associated with pulmonary injury. However, the biological mechanisms of pulmonary damage caused by PM2.5 are poorly defined, especially the ...
Meizhen Li, Qiuhan Hua, Yueting Shao, Huixian Zeng, Yufei Liu, Qinqin Diao, Han Zhang, Miaoyun Qiu, Jialu Zhu, Xun Li, Yihui Ling, Rong Zhang, Yiguo Jiang   +12 more
doaj   +1 more source

Dynamics of Body Composition and Metabolic Risk in Adolescents With Obesity Under GLP‐1 Receptor Agonist Therapy

Acta Paediatrica, Volume 115, Issue 8, Page 1726-1736, August 2026.
ABSTRACT Aim To explore changes in body composition in adolescents with obesity treated with glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) and their association with metabolic syndrome (MetS) components. Methods This real‐world retrospective study included adolescents (12–18 years) with obesity who received multidisciplinary lifestyle‐based ...
Adar Lopez, Liat Perl, Eyal Cohen‐Sela, Ophir Borger, Yael Issan, Hagar Interator, Erez Azoulay, Hadar Moran‐Lev, Ronit Lubetzky, Shira Zelber‐Sagi, Yael Lebenthal, Avivit Brener   +11 more
wiley   +1 more source