Results 91 to 100 of about 1,458 (171)

Adavosertib-encapsulated metal-organic frameworks for p53-mutated gallbladder cancer treatment via synthetic lethality

Science Bulletin
Adavosertib (ADA) is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer (GBC). However, drug resistance due to DNA damage response compensation pathways and high toxicity limits further applications. Herein, estrone-targeted ADA-encapsulated metal-organic frameworks (ADA@MOF-EPL) for GBC synthetic lethal ...
Shijie, Li, Sarun, Juengpanich, Win, Topatana, Tianao, Xie, Lidan, Hou, Yiyuan, Zhu, Jiadong, Chen, Yukai, Shan, Yina, Han, Ziyi, Lu, Tianen, Chen, Charlie, Topatana, Bin, Zhang, Jiasheng, Cao, Jiahao, Hu, Jiafei, Yan, Yingxin, Chen, Zhen, Gu, Jicheng, Yu, Xiujun, Cai, Mingyu, Chen   +20 more
openaire   +2 more sources

Identification of Vesicle‐Mediated Transport‐Related Genes for Predicting Prognosis, Immunotherapy Response, and Drug Screening in Cervical Cancer

Immunity, Inflammation and Disease
Background Cervical cancer is one of the most common malignancies among women. Vesicle‐mediated transport mechanisms significantly influence tumor cell behavior through intercellular material exchange.
Shuai Lou, Hongqing Lv, Lin Zhang
doaj   +1 more source

Supplementary Figure S2 from Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck

, 2019
Supplementary Figure S2 related to Figure 3. Representative image of cell cycle distribution of FaDu and UNC7 cells determined by FACS analysis.
Jeffrey P. Townsend (14963915), Dong-hua Yang (15012759), Ja Seok Koo (14888484), Kyung Jin Eoh (8568471), Wendell G. Yarbrough (232305), Janaki Parameswaran (15012753), Erica A. Golemis (14949004), Natalia Issaeva (839371), Stephen G. Gaffney (15012762), Ilya G. Serebriiskii (14893961), Barbara Burtness (550227), Jong Woo Lee (360063), Fang Zhu (185566), Ranee Mehra (5707862), Teresa Sandoval-Schaefer (15012756), Roshan Sharma (5904719), Elizabeth B. Perry (14920176)   +16 more
core   +1 more source

A network meta-analysis of efficacy and safety for first-line and maintenance therapies in patients with unresectable colorectal liver metastases

Frontiers in Pharmacology
Background: Evidence comparing the efficacy of different treatments for patients with unresectable colorectal liver metastases (CRLM) receiving first-line or maintenance therapy is sparse.
Yunlin Jiang, Yunlin Jiang, Taihang Shao, Mingye Zhao, Yahong Xue, Xueping Zheng   +5 more
doaj   +1 more source

8526 The WEE1 Kinase Inhibitor Adavosertib - A Promising Therapeutic Enhancer Of Cytotoxic Therapies In Advanced Adrenocortical Carcinoma [PDF]

J Endocr Soc
Background: Adrenocortical cancer (ACC) is a rare malignant tumor associated with poor prognosis and limited therapeutic options in advanced cases. Inhibition of WEE1 with adavosertib has emerged as novel strategy for cancer therapy.
Schauer, M P, Steinhauer, S, Sigala, S, Fassnacht, M, Ronchi, C L; id_orcid, Tamburello, M, Weber, J, Wierman, M E, Kiseljak-Vassiliades, K, Holmstoen, T, Landwehr, L S, Urlaub, H, Hudecek, M, Hantel, C, Altieri, B, Kircher, S, Sbiera, S, Kimpel, O, Lippert, J, Detomas, M   +19 more
europepmc   +2 more sources

Adavosertib [PDF]

, 2020
openaire   +1 more source

Supplementary Figure S3 from Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck

, 2019
Supplementary Figure S3 related to Figure 5A-C. (A) Individual tumor volume changes in FaDu-xenografted mice treated with vehicle, adavosertib (30 mg/kg or 90 mg/kg, daily, p.o.), alisertib (30 mg/kg, daily, p.o.), or the combinations of alisertib with ...
Jeffrey P. Townsend (14963915), Dong-hua Yang (15012759), Ja Seok Koo (14888484), Kyung Jin Eoh (8568471), Wendell G. Yarbrough (232305), Janaki Parameswaran (15012753), Erica A. Golemis (14949004), Natalia Issaeva (839371), Stephen G. Gaffney (15012762), Ilya G. Serebriiskii (14893961), Barbara Burtness (550227), Jong Woo Lee (360063), Fang Zhu (185566), Ranee Mehra (5707862), Teresa Sandoval-Schaefer (15012756), Roshan Sharma (5904719), Elizabeth B. Perry (14920176)   +16 more
core   +1 more source

Design Space Visualization and Technoeconomic Evaluation of a Batch Manufacturing Process for the Green Production of an Anti-cancer Drug (Adavosertib) Precursor [PDF]

The development of cost-effective and sustainable manufacturing processes is a growing priority in the pharmaceutical industry, with many companies turning to computational modeling to reduce reliance on experimental campaigns.
Cox, Robert J., Molaei Chalchooghi, Mazaher, Gerogiorgis, Dimitrios I., Blair, Matthew   +3 more
core   +1 more source

BRCA1 Mutation-Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING-Associated Antitumor Immunity in Ovarian Cancer. [PDF]

Adv Sci (Weinh)
Wang C, Yao M, Xie J, Wang D, Shi Y, Mao X, Lu C, Sun P.   +7 more
europepmc   +1 more source

Combination AURKA and WEE1 Inhibition Exhibits Efficacy in EGFR or Pan-ERBB Inhibitor-Resistant Head and Neck Squamous Cell Carcinoma. [PDF]

Cancer Res Commun
Silva FN, Lee JW, Nguyen TT, Goeckel FM, Bagnyukova T, Borghaei H, Golemis EA, Burtness BA.   +7 more
europepmc   +1 more source