Results 71 to 80 of about 1,458 (171)

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, Volume 9, Issue 8, August 2025.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Synthetic Lethality‐Based Targets and Their Exploration in Tumour Combination Strategies

Journal of Cellular and Molecular Medicine, Volume 29, Issue 16, August 2025.
ABSTRACT Synthetic lethality (SL) not only addresses the challenge of drug resistance associated with classical targeted therapies but also offers innovative therapeutic approaches for previously ‘undruggable’ targets, such as deletion mutations in tumour suppressor genes.
Lingya Wu, Yixuan Deng, Zhe Lei, Yuhong Wang, Shan Huang   +4 more
wiley   +1 more source

Supplementary Data from Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition

, 2019
suppl figures 1-6. SF1: Myt1 knockdown sensitizes breast cells to Adavosertib; SF2: Wee1 knockdown mimics Adavosertib treatment; SF3: Adavosertib does not inhibit Myt1 activity; SF4: Adavosertib resistant cells do not prematurely enter mitosis; SF5 ...
Won-Shik Choi (14936028), Cody W. Lewis (14936022), Armin M. Gamper (14936040), Ellen Homola (14936034), Amirali B. Bukhari (103477), Joanne D. Smith (14936031), Shelagh D. Campbell (14936037), Edric J. Xiao (14936025), John R. Mackey (102521), Gordon K. Chan (14936043)   +9 more
core   +1 more source

DataSheet_1_Treatment options for recurrent platinum-resistant ovarian cancer: A systematic review and Bayesian network meta-analysis based on RCTs.docx

, 2023
BackgroundThere are a variety of treatment options for recurrent platinum-resistant ovarian cancer, and the optimal specific treatment still remains to be determined. Therefore, this Bayesian network meta-analysis was conducted to investigate the optimal
Shengpeng Liu (2157241), Chen Yin (4182043), Haowen Yan (8336439), Guorong Zou (4603747), Wei Wang (17594), Juan Li (146180)   +5 more
core   +1 more source

Novel clinical trial designs emerging from the molecular reclassification of cancer

CA: A Cancer Journal for Clinicians, Volume 75, Issue 3, Page 243-267, May/June 2025.
Abstract Next‐generation sequencing has revealed the disruptive reality that advanced/metastatic cancers have complex and individually distinct genomic landscapes, necessitating a rethinking of treatment strategies and clinical trial designs. Indeed, the molecular reclassification of cancer suggests that it is the molecular underpinnings of the disease,
Mina Nikanjam, Shumei Kato, Teresa Allen, Jason K. Sicklick, Razelle Kurzrock   +4 more
wiley   +1 more source

Supplementary Figure S5 from Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck

, 2019
Supplementary Figure S5 related to Figure 5H. (A) Heat map QIF of pCDK1 expression intensity in FaDu xenograft mice treated with (a) vehicle, (b) alisertib, (c) adavosertib or (d) alisertib+adavosertib. Scores range from very low (purple) to high (yellow)
Jeffrey P. Townsend (14963915), Dong-hua Yang (15012759), Ja Seok Koo (14888484), Kyung Jin Eoh (8568471), Wendell G. Yarbrough (232305), Janaki Parameswaran (15012753), Erica A. Golemis (14949004), Natalia Issaeva (839371), Stephen G. Gaffney (15012762), Ilya G. Serebriiskii (14893961), Barbara Burtness (550227), Jong Woo Lee (360063), Fang Zhu (185566), Ranee Mehra (5707862), Teresa Sandoval-Schaefer (15012756), Roshan Sharma (5904719), Elizabeth B. Perry (14920176)   +16 more
core   +1 more source

Wee1 Inhibition Enhances the Anti-Tumor Effects of Capecitabine in Preclinical Models of Triple-Negative Breast Cancer

, 2020
Triple-negative breast cancer (TNBC) is an aggressive subtype defined by lack of hormone receptor expression and non-amplified HER2. Adavosertib (AZD1775) is a potent, small-molecule, ATP-competitive inhibitor of the Wee1 kinase that potentiates the ...
Sarah J. Hartman, D. Ryan Ormond, Todd M. Pitts, Diana Cittelly, Stacey M. Bagby, Brian Gittleman, John J. Tentler, Wells A. Messersmith, Dennis M. Simmons, Betelehem W. Yacob, Jennifer R. Diamond, S. Gail Eckhardt   +11 more
core   +1 more source

Table_1_Treatment options for recurrent platinum-resistant ovarian cancer: A systematic review and Bayesian network meta-analysis based on RCTs.docx

, 2023
BackgroundThere are a variety of treatment options for recurrent platinum-resistant ovarian cancer, and the optimal specific treatment still remains to be determined. Therefore, this Bayesian network meta-analysis was conducted to investigate the optimal
Shengpeng Liu (2157241), Chen Yin (4182043), Haowen Yan (8336439), Guorong Zou (4603747), Wei Wang (17594), Juan Li (146180)   +5 more
core   +1 more source

Preclinical NCI-MPACT: prospective modeling of the mutation-based NCI-MPACT clinical trial therapeutic strategy in patient-derived xenograft models

Frontiers in Oncology
PurposeThe National Cancer Institute’s Molecular Profiling-Based Assignment of Cancer Therapy (NCI-MPACT) randomized phase 2 clinical trial assessed the utility of applying tumor DNA sequencing to treatment selection.
Yvonne A. Evrard, Sergio Y. Alcoser, Michael Mullendore, Li Chen, Chih-Jian Lih, Vishnuprabha Rahul Kannan, Vivekananda Datta, Lindsay Dutko, Shahanawaz Jiwani, Lawrence V. Rubinstein, Yingdong Zhao, P. Mickey Williams, Alida Palmisano, Alida Palmisano, Laura Kuhlmann, Mel Simpson, Shivaani Kummar, Biswajit Das, Chris Karlovich, Eric Polley, Ming-Chung Li, Alice P. Chen, Melinda G. Hollingshead, James H. Doroshow, James H. Doroshow   +24 more
doaj   +1 more source

Identification of m6A-associated autophagy genes in non-alcoholic fatty liver [PDF]

PeerJ
Background Studies had shown that autophagy was closely related to nonalcoholic fat liver disease (NAFLD), while N6-methyladenosine (m6A) was involved in the regulation of autophagy.
Ziqing Huang, Linfei Luo, Zhengqiang Wu, Zhihua Xiao, Zhili Wen   +4 more
doaj   +2 more sources