Results 1 to 10 of about 45,428 (223)

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production [PDF]

OncoImmunology, 2017
Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC), based on the recognition of IgG-opsonized targets by the low-affinity receptor for IgG FcγRIIIA/CD16, represents one of the main mechanisms by which therapeutic antibodies
Cristina Capuano, Chiara Pighi, Rosa Molfetta, Rossella Paolini, Simone Battella, Gabriella Palmieri, Giuseppe Giannini, Francesca Belardinilli, Angela Santoni, Ricciarda Galandrini   +9 more
doaj   +3 more sources

Determinants of natural killer cell-mediated antibody dependent cellular cytotoxicity in SARS-CoV-2 antibodies. [PDF]

PLoS Pathogens
A growing body of evidence underscores the role of antibody-dependent cellular cytotoxicity (ADCC) in antiviral immunity. Yet, the mechanisms underlying the ability of certain antibodies (Abs) to mediate potent ADCC activity remain poorly characterized ...
Delphine M Depierreux, Felicitas Ruiz, Michelle Lilly, Jamie Guenthoer, Vrasha Chohan, Julie Overbaugh   +5 more
doaj   +2 more sources

ADCC Assay Protocol

Bio-Protocol, 2014
Antibody-dependent cell-mediated cytotoxicity (ADCC) bridges innate and adaptive immunity, and it involves both humoral and cellular immune responses.
Vikram Srivastava, Zheng Yang, Ivan Hung, Jianqing Xu, Bojian Zheng, Mei-Yun Zhang   +5 more
doaj   +2 more sources

The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC [PDF]

Nature Communications
HIV-1 envelope glycoproteins (Env) from primary HIV-1 isolates typically adopt a pretriggered “closed” conformation that resists to CD4-induced (CD4i) non-neutralizing antibodies (nnAbs) mediating antibody-dependent cellular cytotoxicity (ADCC).
Jonathan Richard, Michael W. Grunst, Ling Niu, Marco A. Díaz-Salinas, Li Zhu, William D. Tolbert, Lorie Marchitto, Fei Zhou, Catherine Bourassa, Hongil Kim, Sri Lakshmi Tejaswi Boodapati, Derek Yang, Ta Jung Chiu, Hung-Ching Chen, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Suneetha Gottumukkala, Wenwei Li, Katrina Dionne, Étienne Bélanger, Debashree Chatterjee, Halima Medjahed, Wayne A. Hendrickson, Joseph Sodroski, Zabrina C. Lang, Abraham J. Morton, Rick K. Huang, Doreen Matthies, Amos B. Smith, Priti Kumar, Walther Mothes, James B. Munro, Marzena Pazgier, Andrés Finzi   +33 more
doaj   +2 more sources

Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response

OncoImmunology, 2021
The antibody-dependent cellular cytotoxicity (ADCC) effector function of natural killer (NK) cells is one of the known mechanisms of action for rituximab-based anti-cancer immunotherapy.
Dhon Roméo Makanga, Maxime Jullien, Gaëlle David, Nolwenn Legrand, Catherine Willem, Léa Dubreuil, Alexandre Walencik, Cyrille Touzeau, Thomas Gastinne, Benoit Tessoulin, Steven Le Gouill, Béatrice Mahé, Katia Gagne, Patrice Chevallier, Béatrice Clemenceau, Christelle Retière   +15 more
doaj   +1 more source

Do Instabilities in National Macroeconomic Factors Contribute to Channeling Volatility Spillover from the Global to the Islamic Equity Market?

Comparative Economic Research, 2021
This study investigates the impact of macroeconomic instabilities on returns volatility spillover that is transmitted from the global to the Islamic equity market.
Harjum Muharam, Najmudin Najmudin, Wisnu Mawardi, Erman Denny Arfinto   +3 more
doaj   +1 more source

Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy

npj Breast Cancer, 2022
Breast adenoid cystic carcinoma (AdCC) is a rare subtype of triple negative breast cancer. Two morphologic variants are described, namely classic AdCC (C-AdCC) and solid basaloid (SB-AdCC).
Anne Grabenstetter, Edi Brogi, Hong Zhang, Pedram Razavi, Jorge S. Reis-Filho, Kimberly J. VanZee, Larry Norton, Hannah Y. Wen   +7 more
doaj   +1 more source

Distinct clinicopathological and genomic features in solid and basaloid adenoid cystic carcinoma of the breast

Scientific Reports, 2022
Adenoid cystic carcinoma (AdCC) of the breast is a rare indolent carcinoma of salivary gland-type tumors, frequently associated with MYB genetic alteration.
Juan Ji, Fang Zhang, Fanglei Duan, Hong Yang, Jun Hou, Yang Liu, Jie Dai, Qiong Liao, Xian Chen, Qingsong Liu   +9 more
doaj   +1 more source

ADCC: An underappreciated correlate of cross-protection against influenza?

Frontiers in Immunology, 2023
In this short review, we summarized the results obtained with an assay to detect influenza virus-specific antibodies that mediate ADCC, which was developed and evaluated within the framework of the IMI-funded project “FLUCOP”. HA-specific ADCC mediating antibodies were detected in serum samples from children and adults pre- and post-vaccination with ...
de Vries, Rory D., Hoschler, Katja, Rimmelzwaan, Guus F.   +2 more
openaire   +3 more sources

BAFF receptor antibody for mantle cell lymphoma therapy

OncoImmunology, 2021
Mantle cell lymphoma (MCL) is an aggressive form of B cell non-Hodgkin’s lymphoma and remains incurable under current treatment modalities. One of the main reasons for treatment failure is the development of drug resistance.
Keman Zhang, Nand K Roy, Yorleny Vicioso, Janghee Woo, Rose Beck, Marcos de Lima, Paolo Caimi, Daniel Feinberg, Reshmi Parameswaran   +8 more
doaj   +1 more source