Results 21 to 30 of about 5,148 (157)

Liquid chromatography–tandem mass spectrometry method for the estimation of adefovir in human plasma: Application to a pharmacokinetic study

Journal of Pharmaceutical Analysis, 2015
An analytical method based on solid phase extraction was developed and validated for analysis of adefovir in human plasma. Adefovir-d4 was used as an internal standard and Synergi MAX RP80A (150 mm×4.6 mm, 4 µm) column provided the desired ...
Dipanjan Goswami, Sanjay Gurule, Arabinda Saha, Poonam Vats, Arshad Khuroo, Tausif Monif   +5 more
doaj   +1 more source

Quasispecies and Pre-Existing Drug-Resistant Mutations of Hepatitis B Virus in Patients with Chronic Hepatitis B

Gut and Liver, 2013
Background/AimsTo investigate pre-existing hepatitis B virus (HBV) quasispecies and the genotypic evolution of several variants.Methods : From six patients with lamivudine (LAM) failure, serum samples at pretreatment, 6 months of LAM therapy, and ...
doaj   +1 more source

An improved synthesis of adefovir and related analogues

Beilstein Journal of Organic Chemistry, 2019
An improved synthesis of the antiviral drug adefovir is presented. Problems associated with current routes to adefovir include capricious yields and a reliance on problematic reagents and solvents, such as magnesium tert-butoxide and DMF, to achieve high
David J. Jones, Eileen M. O’Leary, Timothy P. O’Sullivan   +2 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Hypophosphatemia Due to Adefovir Treatment [PDF]

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2012
Adefovir dipivoxil is an orally effective prodrug excreted unchanged in urine by glomerular filtration and tubular secretion. While it effectively suppresses hepatitis B virus replication, it may cause nephrotoxicity characterized by severe ...
Nazlım AKTUĞ DEMİR, Servet KÖLGELİER, Serap ÖZÇİMEN, Selçuk AKSÖZ, Ahmet Çağkan İNKAYA   +4 more
doaj  

The Impact of Chronic Hepatitis D Virus Infection on Health‐Related Quality of Life and Fatigue: A Real‐World International Study

Journal of Viral Hepatitis, Volume 33, Issue 9, September 2026.
ABSTRACT As little is known about the disease burden of chronic hepatitis D virus (HDV) infection, this study examined health‐related quality of life (HRQoL) and fatigue at different disease stages. This was a real‐world quantitative cross‐sectional survey of patients in Germany, Italy, Spain and the USA.
P. Lampertico, R. G. Gish, N. Reau, H. Wedemeyer, M. Buti, A. Kaushik, A. Yehoshua, C. Burk, L. Mirams, H. Ellis, T. Taylor‐Whiteley, M. Rock   +11 more
wiley   +1 more source

Management of Antiviral Resistance in Chronic Hepatitis B

Gut and Liver, 2017
The primary goal of therapy for chronic hepatitis B (CHB) is to prevent liver disease progression. Hepatitis B surface antigen (HBsAg) seroclearance or seroconversion is regarded as an optimal endpoint to discontinue treatment.
Young-Suk Lim
doaj   +1 more source

Efficacy of nucleos(t)ide analogues(NAs) in preventing virus reactivation in oncology patients with HBV infection after chemotherapy or surgery: A network meta-analysis

Frontiers in Oncology, 2023
ObjectiveIn this study, we aimed to perform a network meta-analysis to compare the effectiveness of NAs in decreasing the reactivation of HBV, reducing chemotherapy disruption, and improving survival in oncology patients.MethodsRelevant randomized ...
Yuqing Zhao, Yuqing Zhao, Yingying Song, Huan Zhang, Huan Zhang, Tongshuo Qu, Tongshuo Qu, Malina Axinbai, Malina Axinbai, Yidian Yang, Yidian Yang, Liping Zhang, Liping Zhang   +12 more
doaj   +1 more source

Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 465-474, August 2026.
Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Aarzoo Thakur, Jashvant D. Unadkat, Emily E. Fay, Nina Isoherranen, Mary F. Hebert   +4 more
wiley   +1 more source

A Biomimetic Chitosan Derivates: Preparation, Characterization and Transdermal Enhancement Studies of N-Arginine Chitosan

Molecules, 2011
A novel arginine-rich chitosan (CS) derivates mimicked cell penetration peptides; N-Arginine chitosan (N-Arg-CS) was prepared by two reaction methods involving activated L-arginine and the amine group on the chitosan.
Xu-Hui Huang, Wei Wang, Wei Huo, Qing-Qing Cheng, Lu-Lu Hou, Jian-Ping Zhou, Qiang Zhang, Xiao-Pan Wang, Zhen-Hai Zhang, Hui-Xia Lv   +9 more
doaj   +1 more source