ATP Hydrolysis by α‐Synuclein Amyloids is Mediated by Enclosing β‐Strand
Pathological amyloids have been considered chemically inert until recently. Here it is shown that α‐synuclein amyloids catalyze the hydrolysis of the universal energy molecule, ATP. The cryo‐EM structure of the complex reveals an additional β‐strand (purple) that encloses the ATP‐binding site. Within the cavity, several lysine residues are required for
Lukas Frey +6 more
wiley +1 more source
Microvascular Health as a Key Determinant of Organismal Aging
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini +4 more
wiley +1 more source
Microbes and GFR in Health and CKD in Mice. [PDF]
Xu J +11 more
europepmc +1 more source
Methyl Adenine Identification (MadID): High-Resolution Detection of Protein-DNA Interactions
David Umlauf +2 more
openalex +2 more sources
Cell Side-specific Sensitivities of Intracellular Ca2+ Stores for Inositol 1,4,5-Trisphosphate, Cyclic ADP-ribose, and Nicotinic Acid Adenine Dinucleotide Phosphate in Permeabilized Pancreatic Acinar Cells from Mouse [PDF]
Elmar Krause +2 more
openalex +1 more source
Real‐Time Detection of Reduced Nitroreductase with a Reversible Fluorescent Probe
The first reversible binding probe (rNTRp) is presented that selectively detects the nitroreductase enzyme's active, reduced form (red‐NTR) with a fluorescence turn‐on response. Contrary to the conventional reaction‐based probes known to date, which provide only static information on the accumulated enzyme activity at a given time, rNTRp allows ...
Sourav Sarkar +8 more
wiley +1 more source
<i>Lactiplantibacillus plantarum</i> HY7718 Attenuates Renal Injury in an Adenine-Induced Chronic Kidney Disease Mouse Model via Inhibition of Inflammation and Apoptosis. [PDF]
Kim H +8 more
europepmc +1 more source
A natural variation in soybean PM30, GmPM30‐HapT, confers greater salt tolerance than GmPM30‐HapC via stronger GmLEA1‐GmPM30‐GmLEC1 interactions. Pyramiding their elite haplotypes yields additive gains in salt tolerance and yield, establishing a novel workflow linking evolutionary genomics, molecular mechanisms, and breeding applications via the module
Shiyu Huang +13 more
wiley +1 more source

