Results 81 to 90 of about 353,387 (184)

Dominant membrane uncoupling by mutant adenine nucleotide translocase in mitochondrial diseases [PDF]

Human Molecular Genetics, 2008
Adenine nucleotide translocase (Ant) is the most abundant protein on the mitochondrial inner membrane (MIM) primarily involved in ADP/ATP exchange. Ant also possesses a discrete membrane uncoupling activity. Specific mis-sense mutations in the human Ant1 cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), mitochondrial myopathy and ...
Xiaowen, Wang, Kelly, Salinas, Xiaoming, Zuo, Blanka, Kucejova, Xin Jie, Chen   +4 more
openaire   +2 more sources

Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting

MedComm, Volume 7, Issue 9, September 2026.
This review illustrates heat shock proteins (HSPs) as central regulators of cancer metabolic reprogramming. By stabilizing key metabolic enzymes and coordinating glycolysis, oxidative phosphorylation, redox homeostasis, and stress adaptation, HSPs support tumor growth, metastasis, and therapeutic resistance. Targeting HSP networks may therefore provide
Sheng Ma, Chen‐Qian Liu, Si‐Yang Ma, Shao‐Gang Wang, Qi‐Dong Xia, Meng‐Yao Xu   +5 more
wiley   +1 more source

stress sensitive B Encodes an Adenine Nucleotide Translocase in Drosophila melanogaster [PDF]

Genetics, 1999
Abstract Adenine nucleotide translocases (ANT) are required for the exchange of ADP and ATP across the inner mitochondrial membrane. They are essential for life, and most eukaryotes have at least two different Ant genes. Only one gene had been described from Drosophila, and this had not been characterized genetically.
Y Q, Zhang, J, Roote, S, Brogna, A W, Davis, D A, Barbash, D, Nash, M, Ashburner   +6 more
openaire   +2 more sources

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

The roles of translocator protein (TSPO) and adenine nucleotide translocase 2 (ANT2) in breast cancer development and progression

, 2014
"This thesis research aims to investigate the functional roles of TSPO [translocator protein] and ANT2 [adenine nucleotide translocase 2] in breast cancer progression and assess their potential being therapeutic targets for breast cancer treatment ...
Wu, Xiaoting
core   +1 more source

Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older‐Age Bipolar Disorder ISBD Task Forces

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders, Sigfried N. T. M. Schouws, Andrew T. Olagunju, Vicent Balanzá‐Martínez, Nicole C. M. Korten, Ralph W. Kupka, Katherine E. Burdick, Andre F. Carvalho, Ariel G. Gildengers, Lars V. Kessing, Roger S. McIntyre, Paula V. Nunes, Ayal Schaffer, Ivan J. Torres, Shang‐Ying Tsai, Tamsyn E. Van Rheenen, Eduard Vieta, Lakshmi N. Yatham, Allan H. Young, Lisa T. Eyler, Kamilla W. Miskowiak, Annemiek Dols   +21 more
wiley   +1 more source

Adenine nucleotide translocase 2 silencing promotes metabolic reprogramming in P19 embryonal carcinoma stem cells [PDF]

Although controversial, cancer stem cells (CSCs) are thought to be one tumor component, being characterized by their strong self-renewal and survival properties.
Mota, SI, Novak, J, Brisudova, P, Neuzil, J, Oliveira, GL, Marques, R, Oliveira, PJ, Nahacka, Z   +7 more
core   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, Volume 604, Issue 16, Page 6659-6674, 15 August 2026.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source

Developmental changes in the adenine nucleotide translocase in the guinea pig.

Journal of Biological Chemistry, 1984
Investigations of developmental changes in energy metabolism in guinea pig liver mitochondria showed that mitochondria from the newborn were well coupled, with respiratory control ratios and membrane energy potentials similar to those obtained with mitochondria from the 1-day-old and the adult.
D E, Hale, J R, Williamson
openaire   +2 more sources

Decoding the Hot‐Mitochondrion Paradox

BioEssays, Volume 48, Issue 7, July 2026.
A distributed mechanism of mitochondrial heat generation is proposed in which all ion‐translocating proteins embedded within the inner mitochondrial membrane contribute to localized heat generation. All ion‐translocating proteins embedded within the inner mitochondrial membrane (IMM)—with ATP synthase shown here as an example—are proposed to function ...
Peyman Fahimi, Michael Lynch, Chérif F. Matta   +2 more
wiley   +1 more source