Results 91 to 100 of about 6,350 (165)

"Your funeral... my trial": a review of the mechanisms leading to cancer cells death when targeting nicotinamide adenine dinucleotide [PDF]

, 2014
Le nicotinamide adénine dinucléotide (NAD) est un métabolite jouant un rôle crucial dans la vie cellulaire. Dans la mitochondrie, il est surtout utilisé comme co-enzyme d'oxydo-réduction afin de produire de l'énergie sous forme d'ATP (respiration ...
MORISOD, L.
core  

Common and rare variants associated with kidney stones and biochemical traits. [PDF]

, 2015
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Kidney stone disease is a complex disorder with a
Edvardsson, Vidar O, Eyjolfsson, Gudmundur I, Gudbjartsson, Daniel F, Haraldsdottir, Eik, Helgason, Hannes, Holm, Hilma, Indridason, Olafur S, Masson, Gisli, Oddsson, Asmundur, Olafsson, Isleifur, Palsson, Runolfur, Sigurdardottir, Olof, Stefansson, Kari, Sulem, Patrick, Sveinbjörnsson, Gardar, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur   +16 more
core   +1 more source

P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury

Cell Reports, 2014
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs ...
Terry C. Yin, Jeremiah K. Britt, Héctor De Jesús-Cortés, Yuan Lu, Rachel M. Genova, Michael Z. Khan, Jaymie R. Voorhees, Jianqiang Shao, Aaron C. Katzman, Paula J. Huntington, Cassie Wassink, Latisha McDaniel, Elizabeth A. Newell, Laura M. Dutca, Jacinth Naidoo, Huxing Cui, Alexander G. Bassuk, Matthew M. Harper, Steven L. McKnight, Joseph M. Ready, Andrew A. Pieper   +20 more
doaj   +1 more source

Dysregulation of NAD+ metabolism induces a Schwann cell dedifferentiation program [PDF]

, 2018
The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the
Hackett, Amber R, Kim, Sungsu, Milbrandt, Jeffrey, Sasaki, Yo, Strickland, Amy   +4 more
core   +1 more source

Light–dark condition regulates sirtuin mRNA levels in the retina [PDF]

, 2013
Sirtuins (Sirt1–7) are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases/ADP-ribosyltransferases that modulate many metabolic responses affecting aging.
Ban, Norimitsu, Inaba, Takaaki, Miyake, Seiji, Ozawa, Yoko, Shinmura, Ken, Tsubota, Kazuo, Watanabe, Mitsuhiro   +6 more
core   +1 more source

De novo NAD+ synthesis is ineffective for NAD+ supply in axenically cultured Caenorhabditis elegans

Communications Biology
To secure an adequate nicotinamide adenine dinucleotide (NAD+) supply for survival, organisms typically rely on two complementary mechanisms: the de novo synthesis pathway and the salvage pathway.
Shihao Zhu, Runshuai Zhang, Luxia Yao, Zhirong Lin, Yanjie Li, Siyuan Li, Lianfeng Wu   +6 more
doaj   +1 more source

dGTP starvation in Escherichia coli provides new insights into the thymineless-death phenomenon.

PLoS Genetics, 2014
Starvation of cells for the DNA building block dTTP is strikingly lethal (thymineless death, TLD), and this effect is observed in all organisms. The phenomenon, discovered some 60 years ago, is widely used to kill cells in anticancer therapies, but many ...
Mark Itsko, Roel M Schaaper
doaj   +1 more source

Partial Adenine Phosphoribosyltransferase Deficiency Detected by Ureterolithiasis.

Internal Medicine, 1998
A 30-year-old woman was admitted to our hospital because of recurrent ureterolithiasis. She was suspected of having adenine phosphoribosyltransferase (APRT) deficiency based on the presence of 2,8-dihydroxyadenine (DHA) crystals in her urinary sediment, infrared spectrophotometric analysis of the excreted stone, and then the definitive diagnosis by ...
Akihiro Muraoka, Itsuo Suehiro, Kazuhisa Kida, Keiji Murakami, Masatoshi Fujii, Tetsuya Hosooka, Kenjiroh Inagaki, Hirohisa Ueno   +7 more
openaire   +4 more sources

Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy. [PDF]

, 2019
Nicotinamide adenine dinucleotide (reduced form: NADH) serves as a vital redox-energy currency for reduction-oxidation homeostasis and fulfilling energetic demands.
Brewer, Gregory J, Digman, Michelle A, Dong, Yue   +2 more
core   +1 more source

Mechanisms of the NAD+ salvage pathway in enhancing skeletal muscle function

Frontiers in Cell and Developmental Biology
Nicotinamide adenine dinucleotide (NAD+) is crucial for cellular energy production, serving as a coenzyme in oxidation-reduction reactions. It also supports enzymes involved in processes such as DNA repair, aging, and immune responses.
Mengzhu Su, Mengzhu Su, Fanghui Qiu, Yansong Li, Tongtong Che, Ningning Li, Shuangshuang Zhang, Shuangshuang Zhang   +7 more
doaj   +1 more source